Application of Nanoparticles as Innate Immune Stimulator DOI

Mba Ifeanyi Elibe,

Christelle Paul,

Nweze Emeka Innocent

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

A Mn2+‐Assisted Nanofiber‐Hydrogel Adjuvant for Simultaneous Enhancement of Humoral and Cellular Immune Responses DOI

Haixue Jia,

Lin Jia,

Dianyu Wang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(30)

Опубликована: Апрель 9, 2024

Abstract Limited ability to elicit cellular immune responses has restricted the effectiveness of conventional adjuvants in context cancers. Recent advancements innate activation mechanism investigations have paved way for implementation a “bottom‐up” approach development novel adjuvants. Herein, simple hydrogel adjuvant with uniformly organized nanoscale microstructure, termed MnP gel is devised, by employing self‐assembling peptides incorporated manganese ions (Mn 2+ ). exhibits Mn sustained‐release properties vivo and effectively promotes germinal center formation, thereby facilitating generation antibodies at levels comparable aluminum‐based Moreover, transcends scope humoral immunity, demonstrating robustly trigger positioning it as promising candidate cancer prevention treatments. In conclusion, work introduced well‐defined proof‐of‐concept, simplifying vaccine design opening up new avenues “on‐demand” immunomodulation strategies.

Язык: Английский

Процитировано

8
Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development DOI Creative Commons
Meiyan Wu, Yuan Liao,

Di Guo

и другие.

RSC Advances, Год журнала: 2024, Номер 14(21), С. 14722 - 14741

Опубликована: Янв. 1, 2024

Manganese-based nanomaterials have seen rapid development in chemodynamic therapy and T 1 -enhanced MRI over the past five years, holding promising prospects various combined applications.

Язык: Английский

Процитировано

8
Research Progress of Metal–Organic Frameworks as Drug Delivery Systems DOI

Chenxin Liu,

Chaoying Tian,

Jialing Guo

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(33), С. 43156 - 43170

Опубликована: Авг. 12, 2024

Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in biomedical field based on advantages internal porosity, customizable facile surface modification. This review examines utilization drug delivery systems, focusing research progress from aspects coloading intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, multifunctional living carriers. In addition, current challenges faces also discussed. The aims to provide a reference for further application as advanced systems.

Язык: Английский

Процитировано

7
Modulation of Metal Homeostasis for Cancer Therapy DOI

Ying Yang,

Huanhuan Fan, Zijian Guo

и другие.

ChemPlusChem, Год журнала: 2024, Номер 89(6)

Опубликована: Фев. 7, 2024

Metal ions such as iron, zinc, copper, manganese, and calcium are essential for normal cellular processes, including DNA synthesis, enzyme activity, signaling, oxidative stress regulation. When the balance of metal homeostasis is disrupted, it can lead to various pathological conditions, cancer. Thus, understanding role in cancer has led development anti-tumor strategies that specifically target imbalance. Up now, diverse small molecule-based chelators, ionophores, complexes, metal-based nanomaterials have been developed restore metals or exploit dysregulation therapeutic purposes. They hold great promise inhibiting tumor growth, preventing metastasis, enhancing effectiveness existing therapies. In this review, we aim provide a comprehensive summary employed modulate therapy. Their modulation mechanisms succinctly described, their recent applications field therapy discussed. At end, limitations these approaches addressed, potential avenues future developments explored.

Язык: Английский

Процитировано

5
A Lyophilizable LNP Vaccine Enables STING-Reinforced Postoperational Adjuvant Immunotherapy DOI Creative Commons
Yi Yang,

Jiaxin Guo,

Jialong Qi

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Immune checkpoint blockade therapy (iCBT) has revolutionized cancer treatment, however, there is a low response rate, especially in treating postsurgical reoccurring tumors. Vaccine based immunotherapy can sensitize iCBT, but its development was largely hindered by inefficient delivery and high requirements of storage. In this study, the vaccine loaded with immunostimulant employed to improve iCBT-based adjuvant therapy. A lyophilized, antigen E7 peptide manganese ion (Mn2+) co-delivered tumor developed on lipid nanoparticles (EM@LNP). The vaccination efficacy examined both prophylactic therapeutic schemes murine subcutaneous models, synergetic effect combined anti-PD-1 further investigated post-operative model. EM@LNP elicited effective CD8+T cell through modulating immunosuppressive microenvironment conferring immune memory, demonstrating potent immunization preventive schemes. What’s more, orchestrated efficiently repressing recurrence. Further mechanism studies using inhibitor for cells invitro investigation STING−/− mice confirmed that cGAS-STING signaling pathway activated Mn2+ indispensable LNP coordination immunotherapy. summary, study shows lyophilized could significantly amplify iCBT efficiency, providing translational strategy

Язык: Английский

Процитировано

0
Mechanism of Fucoxanthin on Ferroptosis of Human Erythroleukemia Cells Via the TFR1/SLC7A11/GPX4 Signaling Pathway DOI Creative Commons

Bi Wang,

Siyu Wang,

Haofei Du

и другие.

Journal of Contemporary Medical Practice, Год журнала: 2025, Номер 7(1), С. 201 - 211

Опубликована: Янв. 31, 2025

Background: Fucoxanthin (Fx) is a natural carotenoid gaining widespread interest for its anticancer effects. However, the mechanism by which Fx treats leukemia remains unclear. Here, we studied of Fx-induced ferroptosis in human erythroleukemia (HEL) cells. Methods: HEL cell viability after treatment was assessed using an MTT assay. Mitochondrial membrane potential (MMP) and cycle distribution cells were determined flow cytometry. Fucoxanthin's effect on reactive oxygen species (ROS), iron ferrous ions measured assay kits. Expression levels relevant proteins through western blot analysis. Molecular docking performed to validate interactions. Results: significantly inhibited both dose- time-dependently. As concentration increased, proportion G0/G1 phase MMP S notably decreased. markedly promoted ROS, ion expression levels; reduced GPX4 SCL7A11 levels, increased p53 TFR1 levels. analysis revealed that binding energy between GPX4, SCL7A11, less than −5 kcal/mol, primarily hydrogen bonding at enzyme's active site. Conclusion: may be related activation TFR1/SLC7A11/GPX4 signaling pathway.

Язык: Английский

Процитировано

0
Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment DOI Creative Commons

Zui Tian,

Xudong Wang,

Shuai Chen

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1509 - 1528

Опубликована: Фев. 1, 2025

Abstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in progression of inflammatory diseases. Mitochondria, often referred as "power plants" cell, are essential organelles responsible critical functions such energy metabolism, material synthesis, signal transduction. functional state mitochondria closely linked macrophage polarization, prompting interest strategies that target regulate this process. To end, biomaterials with excellent targeting capabilities effective properties have been developed influence mitochondrial function polarization. However, comprehensive summary biomaterial-driven modulation control phenotypes still lacking. This review highlights polarization discusses mediated by biomaterials, including mitochondria-targeted biomaterials. Finally, prospects challenges use these explored, emphasizing their potential be translated clinic. It anticipated will serve valuable resource materials scientists clinicians development next-generation Keywords: macrophages,

Язык: Английский

Процитировано

0
Research Progress on Ferroptosis and Nanotechnology-Based Treatment in Triple-Negative Breast Cancer DOI Creative Commons
Jun Zhang, Shengjun Zhang, Minli Liu

и другие.

Breast Cancer Targets and Therapy, Год журнала: 2024, Номер Volume 16, С. 347 - 358

Опубликована: Июль 1, 2024

Abstract: In recent years, more and researches on cell death mode in breast cancer, including apoptosis, ferroptosis, etc. Ferroptosisis a regulated form of characterized by iron-dependent accumulation lipid peroxidation to lethal levels, numerous studies have shown that ferroptosis is closely associated with tumor cells. Breast cancer one the malignant tumors highest incidence women, TNBC accounts for about 15– 20% all types cancer. Due poor prognosis, strong aggressiveness, high drug resistance lack molecular targeting characteristics TNBC, treatment faces many difficulties great challenges. A large number plays an important role occurrence development diagnosis, among which main mechanisms inducing include oxidative stress pathway, iron metabolism pathway pathway. Since highly sensitive pathways, intracellular GSH reduces reactive oxygen species under action peroxidase (GPX), when (LPO) accumulates certain level, will be induced, thus achieving purpose killing addition, consistent level As new therapeutic method, nanotechnology has added security its safety excellent biocompatibility. Therefore, combination iron-based radiotherapy, chemotherapy, immunization research value novel idea treating ethnopharmacology combined also involved. This article reviews mechanism prospects based nanotechnology, hoping provide references diseases ferroptosis. Keywords: triple-negative

Язык: Английский

Процитировано

4
Tumor Microenvironment Reprogrammed Bimetallic Hybrid Nanostimulator for Triggering Radio‐Cuproptosis‐Immunotherapy DOI Open Access
Xiaohong Jiang, Jin Wang, Weijie Huang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)

Опубликована: Авг. 13, 2024

Radio-immunotherapy driven by radiation-induced immunogenic cell death (ICD) is emerging as a potential opportunity to address conventional radiotherapy (RT) that only applicable localized tumor treatment. However, the effective activation of ICD during RT severely limited radiation dose, weak immunogenicity, and radio-resistance caused microenvironment (TME). Herein, novel bimetallic hybrid nanoscale coordination nanostimulator first proposed phosphate backbone doped with copper ions (Cu

Язык: Английский

Процитировано

4
A Bimetallic Nanomodulator to Reverse Immunosuppression via Sonodynamic‐Ferroptosis and Lactate Metabolism Modulation DOI

Xi Deng,

Yutong Zhu,

Zideng Dai

и другие.

Small, Год журнала: 2024, Номер 20(47)

Опубликована: Авг. 16, 2024

Triple-negative breast cancer (TNBC) responds poorly to immunotherapy due insufficient immunogenicity and highly immunosuppressive tumor microenvironment (TME). Herein, an intelligent calcium/cobalt-based nanomodulator (Ca,Co)CO

Язык: Английский

Процитировано

4