Endogenous and exogeneous stimuli-triggered reactive oxygen species evoke long-lived carbon monoxide to fight against lung cancer
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 16, 2024
Abstract
Reactive
oxygen
species
(ROS)-associated
anticancer
approaches
usually
suffer
from
two
limitations,
i.e.,
insufficient
ROS
level
and
short
half-life.
Nevertheless,
no
report
has
synchronously
addressed
both
concerns
yet.
Herein,
a
multichannel
actions-enabled
nanotherapeutic
platform
using
hollow
manganese
dioxide
(H-MnO
2
)
carriers
to
load
chlorin
e6
(Ce6)
sonosensitizer
CO
donor
(e.g.,
Mn
(CO)
10
been
constructed
maximumly
elevate
trigger
cascade
catalysis
produce
CO.
Therein,
intratumoral
H
O
ultrasound
as
endogenous
exogeneous
triggers
stimulate
H-MnO
Ce6
•OH
1
,
respectively.
The
further
reaction
between
proceeds
release
CO,
converting
short-lived
into
long-lived
Contributed
by
them,
such
maximumly-elevated
accumulation
successfully
suppresses
the
progression,
recurrence
metastasis
of
lung
cancer
with
prolonged
survival
rate.
More
significantly,
proteomic
genomic
investigations
uncover
that
CO-induced
activation
AKT
signaling
pathway,
NRF-2
phosphorylation
HMOX-1
overexpression
induce
mitochondrial
dysfunction
boost
anti-tumor
consequences.
Thus,
this
strategy
can
behave
general
means
enrich
against
refractory
cancers.
Graphic
Язык: Английский
An Activatable Chemiluminescent Self-Reporting Sulfur Dioxide Donor for Inflammatory Response and Regulation of Gaseous Vasodilation
ACS Sensors,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Sulfur
dioxide
(SO2),
being
a
novel
gaseous
signaling
molecule,
exhibits
significant
potential
for
application
in
the
field
of
cardiovascular
diseases.
SO2
donors
serve
as
crucial
tools
transportation
and
regulation
vivo,
facilitating
investigation
physiological
roles
associated
with
this
molecule.
However,
current
therapeutic
lack
capability
to
monitor
real-time
release
SO2,
thereby
hindering
accurate
assessment
their
efficacy
target
localization.
Herein,
we
present
an
activatable
chemiluminescent
self-reporting
donor
(CL-SO2D)
that
can
be
selectively
activated
by
peroxynitrite
(ONOO-)
enable
visualization
extent
through
imaging.
In
vitro
cellular
experiments
demonstrate
CL-SO2D
high
selectivity
signal-to-noise
ratio
toward
ONOO-
effectively
facilitates
process.
Finally,
successfully
achieved
response
mouse
inflammatory
model
relieved
vasoconstriction
zebrafish
releasing
stimulated
ONOO-.
The
findings
suggest
impressive
attributes
diagnosis
treatment
SO2-related
diseases,
opening
gateway
developing
low-background
high-sensitivity
donors.
Язык: Английский
Versatile nanomaterials used in combatting biofilm infections
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Янв. 31, 2025
Microbial
infections
are
a
pressing
global
health
issue,
exacerbated
by
the
rise
of
antibiotic-resistant
bacteria
due
to
widespread
antibiotic
overuse.
This
resistance
diminishes
effectiveness
current
treatments,
intensifying
need
for
new
antimicrobial
agents
and
innovative
drug
delivery
strategies.
Nanotechnology
presents
promising
solutions,
leveraging
unique
properties
nanomaterials
such
as
tunable
optical
electronic
characteristics,
nanoscale
size,
high
surface-to-volume
ratios.
These
features
enhance
their
versatile
systems.
minireview
classifies
into
four
categories
based
on
mechanisms
action:
thermal
generation,
reactive
oxygen
species
gas
nanocarrier
systems
liposomes,
polymersomes,
metal-organic
frameworks.
Uniquely,
this
review
integrates
comparative
analysis
these
mechanisms,
highlighting
relative
advantages,
limitations,
applications
across
diverse
microbial
targets.
Additionally,
it
identifies
emerging
trends
in
field,
providing
forward-looking
perspective
how
recent
advancements
nanotechnology
can
be
leveraged
address
unmet
clinical
needs.
Finally,
article
discusses
future
directions
opportunities
nanotechnology.
Язык: Английский
NIR-Triggered Programmable Nanomotor with H2S and NO Generation for Cascading Oncotherapy by Three-Pronged Reinforcing ICD
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101540 - 101540
Опубликована: Фев. 3, 2025
Язык: Английский
Carbon monoxide gas molecules: Therapeutic mechanisms in radiation-induced lung injury
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
688, С. 250 - 263
Опубликована: Фев. 21, 2025
Язык: Английский
Macrophage membrane coated nanoscale coordination polymers promote graft survival in allogeneic transplantation
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 7, 2025
Язык: Английский
Electronic structure of excited states in carbon monoxide
Solid State Communications,
Год журнала:
2024,
Номер
394, С. 115713 - 115713
Опубликована: Окт. 9, 2024
Язык: Английский
Multifunctional peptide-drug conjugate CORM-401@R9: A novel approach to combat oxidative stress in cataracts
Free Radical Biology and Medicine,
Год журнала:
2024,
Номер
227, С. 570 - 581
Опубликована: Дек. 10, 2024
Язык: Английский
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach
Toxicology Research,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 31, 2024
Abstract
Since
the
Industrial
Revolution,
ecological
damage,
ecosystem
disruption,
and
climate
change
acceleration
have
frequently
resulted
from
human
advancement
at
price
of
environment.
Due
to
rise
in
illnesses,
Industry
6.0
calls
for
a
renewed
dedication
sustainability
with
latest
technologies.
Focused
research
creative
solutions
are
needed
achieve
UN
Sustainable
Development
Goals
(SDGs),
especially
3,
9,
13,
14,
15,
17.
A
promising
sustainable
technology
enhancing
healthcare
while
reducing
environmental
effect
is
Metal
Organic
Frameworks
(MOFs).
MOFs
perfect
drug
administration
because
their
high
surface
areas,
adjustable
pore
sizes,
remarkable
drug-loading
capacities.
They
created
by
combining
advanced
artificial
intelligence,
intelligent
manufacturing,
quantum
computing.
Researchers
can
create
functional
groups
or
ligands
that
bind
selectively
target
cells
tissues,
minimizing
off-target
effects,
thanks
distinct
benefits
families
like
MIL,
HKUST,
UiO,
ZIF
etc.
offer
targeted
delivery.
Combining
other
nanomaterials
results
multipurpose
systems
handle
challenging
biomedical
issues.
Despite
its
promise,
there
still
issues
MOFs’
possible
toxicity
long-term
stability
physiological
settings.
To
advance
medicinal
applications,
these
problems
must
be
resolved.
increase
usefulness
medicine
critically
analysing
limitations
putting
up
alternatives.
The
creation
technologies
(additive
manufacturing
etc.)
delivery
prime
example
how
scientific
stewardship
may
coexist
provide
advantageous
both
people
Язык: Английский