Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach DOI
M. Akhtar, Hammad Majeed, Tehreema Iftikhar

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 31, 2024

Abstract Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at price of environment. Due to rise in illnesses, Industry 6.0 calls for a renewed dedication sustainability with latest technologies. Focused research creative solutions are needed achieve UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs perfect drug administration because their high surface areas, adjustable pore sizes, remarkable drug-loading capacities. They created by combining advanced artificial intelligence, intelligent manufacturing, quantum computing. Researchers can create functional groups or ligands that bind selectively target cells tissues, minimizing off-target effects, thanks distinct benefits families like MIL, HKUST, UiO, ZIF etc. offer targeted delivery. Combining other nanomaterials results multipurpose systems handle challenging biomedical issues. Despite its promise, there still issues MOFs’ possible toxicity long-term stability physiological settings. To advance medicinal applications, these problems must be resolved. increase usefulness medicine critically analysing limitations putting up alternatives. The creation technologies (additive manufacturing etc.) delivery prime example how scientific stewardship may coexist provide advantageous both people

Language: Английский

Endogenous and exogeneous stimuli-triggered reactive oxygen species evoke long-lived carbon monoxide to fight against lung cancer DOI Creative Commons

Yujia Fang,

Jianjun Yang, Xiayi Liang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 16, 2024

Abstract Reactive oxygen species (ROS)-associated anticancer approaches usually suffer from two limitations, i.e., insufficient ROS level and short half-life. Nevertheless, no report has synchronously addressed both concerns yet. Herein, a multichannel actions-enabled nanotherapeutic platform using hollow manganese dioxide (H-MnO 2 ) carriers to load chlorin e6 (Ce6) sonosensitizer CO donor (e.g., Mn (CO) 10 been constructed maximumly elevate trigger cascade catalysis produce CO. Therein, intratumoral H O ultrasound as endogenous exogeneous triggers stimulate H-MnO Ce6 •OH 1 , respectively. The further reaction between proceeds release CO, converting short-lived into long-lived Contributed by them, such maximumly-elevated accumulation successfully suppresses the progression, recurrence metastasis of lung cancer with prolonged survival rate. More significantly, proteomic genomic investigations uncover that CO-induced activation AKT signaling pathway, NRF-2 phosphorylation HMOX-1 overexpression induce mitochondrial dysfunction boost anti-tumor consequences. Thus, this strategy can behave general means enrich against refractory cancers. Graphic

Language: Английский

Citations

5
An Activatable Chemiluminescent Self-Reporting Sulfur Dioxide Donor for Inflammatory Response and Regulation of Gaseous Vasodilation DOI

Chengyuan Lv,

Zipeng Li, Wenkai Liu

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Sulfur dioxide (SO2), being a novel gaseous signaling molecule, exhibits significant potential for application in the field of cardiovascular diseases. SO2 donors serve as crucial tools transportation and regulation vivo, facilitating investigation physiological roles associated with this molecule. However, current therapeutic lack capability to monitor real-time release SO2, thereby hindering accurate assessment their efficacy target localization. Herein, we present an activatable chemiluminescent self-reporting donor (CL-SO2D) that can be selectively activated by peroxynitrite (ONOO-) enable visualization extent through imaging. In vitro cellular experiments demonstrate CL-SO2D high selectivity signal-to-noise ratio toward ONOO- effectively facilitates process. Finally, successfully achieved response mouse inflammatory model relieved vasoconstriction zebrafish releasing stimulated ONOO-. The findings suggest impressive attributes diagnosis treatment SO2-related diseases, opening gateway developing low-background high-sensitivity donors.

Language: Английский

Citations

0
Versatile nanomaterials used in combatting biofilm infections DOI
Chenlong Wang, S. M. Shatil Shahriar, Yajuan Su

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 31, 2025

Microbial infections are a pressing global health issue, exacerbated by the rise of antibiotic-resistant bacteria due to widespread antibiotic overuse. This resistance diminishes effectiveness current treatments, intensifying need for new antimicrobial agents and innovative drug delivery strategies. Nanotechnology presents promising solutions, leveraging unique properties nanomaterials such as tunable optical electronic characteristics, nanoscale size, high surface-to-volume ratios. These features enhance their versatile systems. minireview classifies into four categories based on mechanisms action: thermal generation, reactive oxygen species gas nanocarrier systems liposomes, polymersomes, metal-organic frameworks. Uniquely, this review integrates comparative analysis these mechanisms, highlighting relative advantages, limitations, applications across diverse microbial targets. Additionally, it identifies emerging trends in field, providing forward-looking perspective how recent advancements nanotechnology can be leveraged address unmet clinical needs. Finally, article discusses future directions opportunities nanotechnology.

Language: Английский

Citations

0
NIR-Triggered Programmable Nanomotor with H2S and NO Generation for Cascading Oncotherapy by Three-Pronged Reinforcing ICD DOI Creative Commons
Jinlong Zhang, Quan Jing,

L. Yuan

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101540 - 101540

Published: Feb. 3, 2025

Language: Английский

Citations

0
Carbon monoxide gas molecules: Therapeutic mechanisms in radiation-induced lung injury DOI
Yanan Li, Bingshuai Zhou,

Deyang Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 688, P. 250 - 263

Published: Feb. 21, 2025

Language: Английский

Citations

0
Macrophage membrane coated nanoscale coordination polymers promote graft survival in allogeneic transplantation DOI Creative Commons
Haili Bao,

Shaohua Song,

Hao Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

Language: Английский

Citations

0
Electronic structure of excited states in carbon monoxide DOI
A. V. Popov,

Olga S. Melnikova,

N. V. Melnikova

et al.

Solid State Communications, Journal Year: 2024, Volume and Issue: 394, P. 115713 - 115713

Published: Oct. 9, 2024

Language: Английский

Citations

0
Multifunctional peptide-drug conjugate CORM-401@R9: A novel approach to combat oxidative stress in cataracts DOI
Yilin Chen, Haixu Chen,

Z. Li

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 227, P. 570 - 581

Published: Dec. 10, 2024

Language: Английский

Citations

0
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach DOI
M. Akhtar, Hammad Majeed, Tehreema Iftikhar

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 31, 2024

Abstract Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at price of environment. Due to rise in illnesses, Industry 6.0 calls for a renewed dedication sustainability with latest technologies. Focused research creative solutions are needed achieve UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs perfect drug administration because their high surface areas, adjustable pore sizes, remarkable drug-loading capacities. They created by combining advanced artificial intelligence, intelligent manufacturing, quantum computing. Researchers can create functional groups or ligands that bind selectively target cells tissues, minimizing off-target effects, thanks distinct benefits families like MIL, HKUST, UiO, ZIF etc. offer targeted delivery. Combining other nanomaterials results multipurpose systems handle challenging biomedical issues. Despite its promise, there still issues MOFs’ possible toxicity long-term stability physiological settings. To advance medicinal applications, these problems must be resolved. increase usefulness medicine critically analysing limitations putting up alternatives. The creation technologies (additive manufacturing etc.) delivery prime example how scientific stewardship may coexist provide advantageous both people

Language: Английский

Citations

0