International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10745 - 10765
Опубликована: Окт. 1, 2024
Tissue
engineering
aims
to
recreate
natural
cellular
environments
facilitate
tissue
regeneration.
Gelatin
methacrylate
(GelMA)
is
widely
utilized
for
its
biocompatibility,
ability
support
cell
adhesion
and
proliferation,
adjustable
mechanical
characteristics.
This
study
developed
a
GelMA
graphene
bioink
platform
at
concentrations
of
1,
1.5,
2
mg/mL
enhance
scaffold
properties
applications.
To
study
the
effect
on
biomaterial
degradation
and
bone
formation
of
different
ratios
between
α-tricalcium
phosphate
(α-TCP)
deproteinized
bovine
mineral
(DBBM)
using
various
gelatins
as
a
carrier.
Thirty-six
critical-sized
calvarial
defects
were
randomly
treated
in
18
animals.
Four
biomaterials
with
compositional
relations
DBBM
to
α-TCP
granules
carrier
investigated:
(1)
40
±
10%
DBBM/40
20
gelatin
type
1
ratio
4:1
(B1/G1),
(2)
DBBM/60
(B2/G1),
(3)
15
10%/5
5%
2/
glycerine
(B2/G2)
4),
10
10%/10
(B3/G2).
As
positive
control
50
DBBM/50
without
(PC,
B1/G0)
negative
(NC)
empty
chosen.
All
covered
collagen
membrane.
The
samples
harvested
4
weeks
post-surgically
examined
by
micro-CT
histomorphometric
analysis.
New
was
evident
all
defects.
mineralized
tissue
volume
significantly
higher
four
tested
than
NC
group,
but
lower
compared
PC
group.
Histomorphometry
showed
similar
levels
groups,
whereas
only
group
reached
total
augmentation
area
that
NC.
density
residual
material
B3/G2
more
biomaterials.
not
affected
either
DBBM:α-TCP
nor
presence
carriers.
Similar
osteoconductivity
indicates
presumptive
use
combined
products
alveolar
ridge
support
formation.
Gelatin
or
may
be
considered
for
its
frequently
applied
peri-implant
surgery.
Gels,
Год журнала:
2025,
Номер
11(3), С. 191 - 191
Опубликована: Март 8, 2025
Three-dimensional
bioprinting
is
a
new
advance
in
tissue
engineering
and
regenerative
medicine.
Bioprinting
allows
manufacturing
three-dimensional
(3D)
structures
that
mimic
tissues
or
organs.
The
bioinks
used
are
mainly
made
of
natural
synthetic
polymers
must
be
biocompatible,
printable,
biodegradable.
These
may
incorporate
progenitor
cells,
favoring
graft
implantation
regeneration
injured
tissues.
However,
the
natures
biomaterials,
processes,
lack
vascularization,
immune
responses
factors
limit
viability
functionality
implanted
cells
damaged
limitations
can
addressed
by
incorporating
extracellular
vesicles
(EV)
into
bioinks.
Indeed,
EV
from
have
capacities,
being
similar
to
those
their
source
cells.
Therefore,
combinations
with
biomaterials
cell-free
therapies.
Likewise,
they
complement
manufacture
increasing
viability,
differentiation,
ability
incorporated
Thus,
main
objective
this
review
show
how
use
3D
technology
for
application
medicine
these
nanovesicles
hydrogels
as
To
end,
latest
advances
derived
vitro
vivo
studies
been
described.
Together,
high
therapeutic
potential
strategy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Bio-inspired
coral-derived
scaffolds
have
been
adopted
for
bone
regeneration.
However,
these
confront
challenges
such
as
the
limited
osteoinductive
properties,
environmental
concerns,
and
ambiguous
calcification
mechanisms
in
coral
proteins.
In
this
study,
role
of
recombinant
protein
galaxin
promoting
osteogenesis
is
investigated.
The
observations
reveal
that
regulates
mitochondrial
metabolism
mouse
pre-osteoblasts
by
interacting
with
β
subunit
ATP
synthase.
This
ultimately
promotes
pre-osteoblasts.
Furthermore,
integrated
gelatin
methacryloyl
(GelMA)
assess
osteogenic
potential
resulting
galaxin-GelMA
composites
mandibular
defects.
emphasize
distinctive
regulating
functionality
osteogenesis.
Additionally,
provide
prospective
insights
further
applications
bio-inspired
proteins
regenerative
medicine.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 23
Опубликована: Апрель 9, 2025
Black
phosphorus
nanosheets
(BP)
have
been
widely
used
in
bone
tissue
engineering
due
to
their
superior
properties
and
good
biocompatibility,
as
well
the
fact
that
they
are
composed
of
only
a
single
element
phosphorus,
which
is
highly
homologous
inorganic
components
natural
bone.
Hydrogels
based
on
gelatin
methacryloyl
(GelMA)/hyaluronic
acid
(HAMA)
composites
were
prepared
by
photocrosslinking.
The
physicochemical
GelMA/HAMA,
GelMA/HAMA/BP,
GelMA/HAMA/BMP2
GelMA/HAMA/BP@BMP2
hydrogels
characterized
using
Fourier
transform
infrared
spectroscopy
(FTIR),
dynamic
light
scattering
(DLS),
transmission
electron
microscopy
(TEM),
scanning
(SEM).
In
addition,
mechanical
properties,
swelling
rate
degradation
investigated,
results
showed
possessed
suitable
for
cell
adhesion
growth
proliferation.
BP
carrier
could
ensure
stable
sustained
release
bioactive
factor:
morphogenetic
protein
2
(BMP2),
promote
recruitment
osteogenic
differentiation
marrow
mesenchymal
stem
cells
(BMSCs),
its
binding
surrounding
calcium
ions
can
biomineralization.
Therefore,
this
BMP2-modified
black
hydrogel
system
provides
new
strategy
regeneration.
