Coordination Chemistry Reviews, Год журнала: 2024, Номер 527, С. 216419 - 216419
Опубликована: Дек. 28, 2024
Язык: Английский
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер 207, С. 104625 - 104625
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
1
Drug Delivery, Год журнала: 2024, Номер 31(1)
Опубликована: Сен. 10, 2024
The unavoidable residual tumor tissue from surgery and the strong aggressiveness of cells pose challenges to postoperative treatment patients, accompanied by in situ recurrence decreased quality life. Therefore, there is an urgent need explore appropriate therapeutic strategies remove after inhibit metastasis surgery. In recent years, with rapid development biomedical materials, study local delivery systems as agents has gradually attracted attention researchers. Injectable situ-forming hydrogel a locally administered agent injected solution that can be loaded various rapidly gels form semi-solid gel at site. This type tightly fills surgical site covers irregular excision surfaces. this paper, we review advances application injectable hydrogels therapy, focusing on matrix materials its different types tumors, well discussing prospects clinical application.
Язык: Английский
Процитировано
4
Nano-Micro Letters, Год журнала: 2024, Номер 17(1)
Опубликована: Сен. 30, 2024
Abstract Vaccinations are essential for preventing and treating disease, especially cancer nanovaccines, which have gained considerable interest recently their strong anti-tumor immune capabilities. Vaccines can prompt the system to generate antibodies activate various cells, leading a response against tumor tissues reducing negative effects recurrence risks of traditional chemotherapy surgery. To enhance flexibility targeting vaccines, nanovaccines utilize nanotechnology encapsulate or carry antigens at nanoscale level, enabling more controlled precise drug delivery responses. Cancer function by encapsulating tumor-specific tumor-associated within nanomaterials. The small size these nanomaterials allows T dendritic thereby eliciting potent response. In this paper, we focus on classification carriers roles different target clinically tested discussing strategies effectively inducing cytotoxic lymphocytes responses optimizing antigen presentation, while also looking ahead translational challenges moving from animal experiments clinical trials.
Язык: Английский
Процитировано
4
Small Structures, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
As two main phototherapy means, photodynamic therapy (PDT) and photothermal (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), thus PDT or PTT efficiency can be regulated regulating PSs aggregation. A co‐assembly formulation consisting IR780 iodide pentafluorophenyl trifluoroacetate is constructed through intermolecular interactions, followed coating with hyaluronic acid. Initially, uniform distribution favors more reactive oxygen species birth to implement when entering cells since its avenue sequential process intersystem crossing transfer–collision energy transfer predominant. After hyaluronidase laser irradiation‐induced structural collapse co‐assembly, free aggregates due hydrophobic interactions even though they are excreted out cells, then, these produce heat nonradiative relaxation execute PTT. Such a spatiotemporal PDT–PTT encourages antitumor immune responses mitigates immunosuppression, accomplishing photoimmunotherapy against breast cancer progression. Through such tumor microenvironment‐adaptable laser‐duration‐decided alteration, switching insights provided into single PSs‐mediated photoimmunotherapy.
Язык: Английский
Процитировано
0
Biomarker Research, Год журнала: 2025, Номер 13(1)
Опубликована: Янв. 23, 2025
Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 6, 2025
Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, tumors. While they help capture eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly achieving precise drug delivery maintaining stability. Nanoparticle (NP)-based systems offer innovative solutions for overcoming limitations conventional therapies. This review explores biological mechanisms formation, their interactions with NPs, therapeutic applications NP-based modulating NETs. We discuss how NPs be designed either promote inhibit provide a comprehensive analysis potential treating NET-related diseases. Additionally, we address current future prospects therapies research, aiming bridge gap between nanotechnology development novel approaches.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Small Structures, Год журнала: 2025, Номер unknown
Опубликована: Март 8, 2025
Immune checkpoint blockade (ICB) therapy is a promising treatment that has shown significant effects in certain refractory and advanced cancers. However, not all patients respond to ICB therapy. The tumor microenvironment (TME) helps tumors evade immune surveillance attack, contributing the low response rate M1 macrophages primarily exert antitumor within TME, whereas M2 support growth evasion through various mechanisms, making them crucial component of TME. To reduce macrophages, mitigate ultimately enhance therapy, perfluoropentane (PFP) used as phase‐change material hematoporphyrin monomethyl ether incorporated into nanodroplets (NDs). With mannose modification on their surface, these NDs can effectively target denoted MPH@NDs. When exposed low‐intensity focused ultrasound, MPH@NDs cause mechanical injury produce reactive oxygen species. This will lead remodeling distribution transforming it proinflammatory microenvironment. enhances cytotoxic T lymphocytes accumulation tumors, remodels improves PD‐L1 immunotherapy efficacy. demonstrate potential enhancing suppressing distant metastasis.
Язык: Английский
Процитировано
0
Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0
Advances in Clinical Medicine, Год журнала: 2025, Номер 15(04), С. 958 - 966
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0