Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104715 - 104715

Опубликована: Апрель 1, 2025

Язык: Английский

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NDP@MnO₂ hydrogel combined with photothermal therapy for postoperative anti-recurrence treatment of pancreatic cancer

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Surgical resection remains a potentially curative treatment option for pancreatic cancer (PC). However, the high rate of local tumor recurrence and poor prognosis severely limit its therapeutic efficacy. In this study, we report an injectable thermosensitive hydrogel platform (designated as NDP@MnO₂ hydrogel) that exhibits excellent biocompatibility, photothermal performance, wet adhesion properties, specifically designed precise post-operative therapy. This system innovatively combines shear-thinning injectability, dopamine-mediated tissue adhesion, MnO₂-enhanced ablation capabilities. By precisely targeting hyperthermia to moist irregular margins during sol-gel transition subsequent exposure 808 nm laser, approach can effectively selectively eliminate residual cells while minimizing collateral damage adjacent healthy tissues. Notably, pre-clinical studies have demonstrated significantly reduces locoregional in models, thereby offering promising solution critical issue postoperative recurrence.

Язык: Английский

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Poloxamer-based drug delivery systems: Frontiers for treatment of solid tumors

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101727 - 101727

Опубликована: Апрель 1, 2025

Pluronics or poloxamers are a type of triblock copolymer. These non-ionic molecules consist hydrophobic block embedded in two hydrophilic parts. have become favorite materials for use the field biomedical research due to having favorable physicochemical and biological properties such as amphiphilicity, solubility ionic solutions, biocompatibility, biodegradability, self-assembly low toxicity. The scope these applications can vary from tissue engineering drug delivery. One important uses pluronics is deliver drugs various cancer cells. Herein we first provide an overview on variety ploronic biomaterials. And then intensively evaluate their potential delivery systems (DDSs) treatment solid tumors with special focus breast cancers. After explaining pros cons pluronics, current status clinical settings future prospects highlighted.

Язык: Английский

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Carrageenan‐Based Hydrogels for Advanced Wound Healing and Controlled Drug Delivery in Tissue Engineering

Journal of Biomedical Materials Research Part B Applied Biomaterials, Год журнала: 2025, Номер 113(5)

Опубликована: Май 1, 2025

ABSTRACT Carrageenan (CGN) is a high molecular weight polysaccharide that extracted from red seaweeds. It made up of D‐galactose residues connected by β‐1,4 and α‐1,3 galactose‐galactose bonds. As result its ability to thicken, emulsify, stabilize food, it frequently used as food additive in processed food. Its consumption has surged recent years due the Western diet's (WD) spread. change thickness mucus barrier, composition gut microbiota, innate immune pathway causes inflammation. Also, inherent qualities, which include biodegradability, biocompatibility, resemblance native glycosaminoglycans, antioxidants, anticancer, immunomodulatory, anticoagulant activities, Carrageenan‐based hydrogels have been subject numerous investigations lately for biomedical applications. The brittle hydrogel uncontrollably exchanged ions, however, are two drawbacks application this polysaccharide, but these can be avoided making straightforward chemical changes polymer networks, create chemically bonded with important mechanical characteristics regulated degradation rates. Furthermore, addition diverse kinds nanoparticles, well carrageenan results hybrid platforms noteworthy mechanical, chemical, biological characteristics, qualify them appropriate biomaterials tissue engineering (TE), drug delivery (DD), also wound healing Our goal article provide an overview most current developments carrageenan‐based several modification techniques TE DD

Язык: Английский

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Multifunctional Hydrogels for Advanced Cancer Treatment: Diagnostic Imaging and Therapeutic Modalities

Gels, Год журнала: 2025, Номер 11(6), С. 426 - 426

Опубликована: Июнь 1, 2025

Multifunctional hydrogels represent an emerging technological advancement in cancer therapeutics, integrating diagnostic imaging capabilities with therapeutic modalities into comprehensive, multifunctional systems. These exhibit exceptional biocompatibility, biodegradability, high water retention capacity, and tunable mechanical properties, enabling precise drug delivery while minimizing systemic side effects. Recent innovations stimuli-responsive components facilitate intelligent, controlled release mechanisms triggered by various stimuli, including changes pH, temperature, magnetic fields, near-infrared irradiation. Incorporating agents, such as nanoparticles, fluorescent dyes, radiolabeled isotopes, substantially improves tumor visualization real-time monitoring. effectively integrate chemotherapy, photothermal therapy, photodynamic immunotherapy, their synergistic combinations, demonstrating superior outcomes compared to conventional methods. Particularly, injectable situ-forming provide sustained local postoperatively, reducing recurrence. However, challenges persist, initial burst release, instability, regulatory barriers, scalability concerns. Current research emphasizes advanced nanocomposite formulations, biofunctionalization strategies, innovative manufacturing technologies like 3D bioprinting clinical translation. This review comprehensively summarizes recent advancements, applications, future perspectives of hydrogel systems for enhanced treatment, underscoring potential revolutionize personalized oncology.

Язык: Английский

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Research progress of paclitaxel nanodrug delivery system in the treatment of triple-negative breast cancer

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101358 - 101358

Опубликована: Ноя. 23, 2024

Язык: Английский

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