Nanomaterials,
Год журнала:
2024,
Номер
14(23), С. 1875 - 1875
Опубликована: Ноя. 22, 2024
The
increasing
prevalence
of
multidrug-resistant
(MDR)
pathogens,
persistent
biofilms,
oxidative
stress,
and
cancerous
cell
proliferation
poses
significant
challenges
in
healthcare
environmental
settings,
highlighting
the
urgent
need
for
innovative
sustainable
therapeutic
solutions.
exploration
nanotechnology,
particularly
use
green-synthesized
nanoparticles,
offers
a
promising
avenue
to
address
these
complex
biological
due
their
multifunctional
properties
biocompatibility.
Utilizing
green
synthesis
approach,
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 81 - 81
Опубликована: Янв. 12, 2025
This
narrative
review
explores
the
potential
effects
of
Propolis
and
its
bioactive
compounds
on
bone
health.
Propolis,
a
resinous
product
collected
by
bees,
is
renowned
for
antimicrobial,
anti-inflammatory,
antioxidant
properties.
Recent
research
emphasizes
positive
role
in
osteogenesis,
primarily
through
modulation
osteoclast
osteoblast
activity
via
molecular
pathways.
Key
mechanisms
include
reducing
inflammatory
cytokines,
protecting
against
oxidative
stress,
upregulating
growth
factor
essential
formation.
While
such
as
Caffeic
Acid
Phenethyl
Ester,
Apigenin,
Quercetin,
Ferulic
have
been
well-documented,
emerging
evidence
points
to
significant
roles
less-studied
like
Pinocembrin,
Kaempferol,
p-Coumaric
acid,
Galangin.
synthesizes
current
literature,
focusing
which
these
influence
osteogenesis.
Firstly,
it
techniques
characterizing
presented
propolis,
chemogeographic
variations
composition,
both
crude
extracts
isolated
tissue,
offering
comprehensive
analysis
recent
findings
across
different
experimental
models.
Further,
discusses
In
summary,
modulate
signaling
pathways,
including
nuclear
kappa
beta,
wingless-related
integration
site,
mitogen-activated
protein
kinase,
vascular
endothelial
factor,
reactive
oxygen
species.
These
pathways
receptor
activator
kappa-β/receptor
kappa-β
ligand/osteoprotegerin
system,
fostering
cell
differentiation.
regulation
mitigates
excessive
formation,
stimulates
activity,
ultimately
contributes
restoration
homeostasis
maintaining
balanced
remodeling
process.
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 265 - 265
Опубликована: Фев. 25, 2025
Bee
pollen
(BP)
is
one
of
the
richest
known
natural
resources
micronutrients
and
bioactive
phytochemicals.
Some
captivating
bioactivities
BP
compounds,
although
being
largely
investigated
for
latter
as
individual
molecules,
remain
very
scarcely
or
completely
uninvestigated
in
bee
a
whole
product.
Among
most
intriguing
these
bioactivities,
we
identified
ferroptosis
major
one.
Ferroptosis,
recently
discovered
form
cell
death
(connecting
oxidative
stress
inflammation),
complex
pathophysiological
process
crucial
perplexing
events
current
challenging
human
diseases
such
cancer,
neurodegeneration,
general
aging
diseases.
Many
compounds
were
found
to
intricately
modulate
depending
on
cellular
context
by
inducing
this
mechanism
malignant
cells
preventing
it
non-malignant
cells.
Since
research
both
fields,
i.e.,
ferroptosis,
still
recent,
deemed
necessary
undertake
review
figure
out
extent
potential
modulating
mechanisms.
Our
proved
that
wide
range
(polyphenols,
phenolamides,
carotenoids,
vitamins,
minerals,
others)
substantially
diverse
Accordingly,
phytochemicals
nutrients
showed
interesting
preclinical
studies
lead
ferroptosis-mediated
outcomes
important
processes,
including
many
aging-related
disorders.
One
paramount
challenges
be
resolved
determine
how
different
act
biological
contexts,
either
through
synergistic
antagonistic
behaviors.
We
hope
our
work
constitutes
valuable
incentive
future
investigations
promising
relevant
avenue.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Guided
tissue
regeneration
(GTR)
using
barrier
membranes
is
a
common
clinical
approach
for
treating
periodontitis-induced
alveolar
bone
loss.
However,
conventional
GTR
lack
antibacterial
and
osteoinductive
properties,
limiting
their
effectiveness.
Piezoelectric
materials,
which
generate
electrical
outputs
under
chewing
forces,
offer
bone-regenerative
potential
due
to
oppositely
charged
surfaces.
Inspired
by
this,
piezoelectric
Janus
membrane
was
developed
dual-function
therapy.
Biodegradable
poly(l-lactide)
(PLLA)
PLLA/gelatin
were
electrospun,
annealed,
polarized
create
the
A-P(+)/PG(-)
membrane.
Notably,
in
this
membrane,
outer
surface
of
PLLA
side
(A-P(+))
carries
positive
charges
positioned
toward
gingival
kill
bacteria
via
charge
interactions;
inner
PG
(PG(-))
holds
negative
faces
defect,
promoting
growth
through
immunomodulation
enhanced
mineralization.
In
mouse
model
periodontitis,
demonstrated
dual
functionality,
effectively
reducing
inflammation,
inhibiting
resorption.
The
mineral
density
reached
1637
±
37
mg/cm3
at
8
weeks
after
surgery,
superior
commercial
collagen
lacking
properties.
Overall,
study
introduces
an
innovative
approach,
leveraging
biodegradable
construct
versatile
with
osteogenic
activity
periodontitis
treatment.
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3587 - 3587
Опубликована: Окт. 22, 2024
In
degenerative
joint
disease
like
osteoarthritis
(OA),
bioactive
compounds
resveratrol,
epigallocatechin
gallate,
curcumin,
and
other
polyphenols
often
target
various
signalling
pathways,
including
NFκB,
TGFβ,
Wnt/β-catenin
by
executing
epigenetic-modifying
activities.
Epigenetic
modulation
can
genes
of
pathophysiology
via
histone
modification,
promoter
DNA
methylation,
non-coding
RNA
expression,
some
which
are
directly
involved
in
OA
but
have
been
less
explored.
patients
seek
options
that
improve
the
quality
their
life
addition
to
existing
treatment
with
nonsteroidal
anti-inflammatory
drugs
(NSAIDs).
Although
natural
exhibit
therapeutic
potential
against
OA,
several
disadvantages
loom,
insolubility
poor
bioavailability.
Nanoformulated
promise
a
better
way
alleviate
since
they
also
control
systemic
events,
metabolic,
immunological,
inflammatory
responses,
modulating
host
gut
microbiota
regulate
pathogenesis.
Recent
data
suggest
dysbiosis
OA.
However,
limited
evidence
is
available
on
role
as
epigenetic
modulators
ameliorating
Moreover,
it
not
known
whether
effects
polyphenolic
microbial
response
mediated
modulatory
activities
This
narrative
review
highlights
nanotherapeutic
strategies
utilizing
compounds,
reporting
chondrocyte
growth,
metabolism,
modifications
amelioration.
Separations,
Год журнала:
2024,
Номер
11(11), С. 311 - 311
Опубликована: Окт. 28, 2024
After
harvesting,
the
substrate
of
Flammulina
velutipes
(SFV)
is
repurposed
for
uses
such
as
feed,
fuel,
and
culture
medium.
This
study
identified
four
phenolic
acids
one
flavonoid
from
SFV
first
time
using
solvent
extraction
chromatography:
ferulic
acid
(1),
ρ-coumaric
(2),
vanillic
(3),
3-methoxygallic
(4),
tricin
(5).
They
showed
significant
activity
in
DPPH
scavenging
test
with
concentrations
determined
by
HPLC
follows:
(218.88
mg/kg),
(157.31
(281.54
(33.85
(713.42
mg/kg).
These
findings
indicate
that
a
valuable
source
bioactive
compounds
medicinal
health-promoting
applications.
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Degenerative
bone
and
joint
diseases
(DBJDs),
characterized
by
osteoporosis,
osteoarthritis,
chronic
inflammation
of
surrounding
soft
tissues,
are
systemic
conditions
primarily
affecting
the
skeletal
system.
Ferroptosis,
a
programmed
cell
death
pathway
distinct
from
apoptosis,
autophagy,
necroptosis.
Accumulating
evidence
suggests
that
ferroptosis
is
intricately
linked
to
pathogenesis
DBJDs,
targeting
its
regulation
could
be
beneficial
in
managing
these
conditions.
Natural
products,
known
for
their
anti-inflammatory
antioxidant
properties,
have
shown
unique
advantages
preventing
potentially
through
modulating
ferroptosis.
This
article
provides
an
overview
latest
research
on
ferroptosis,
with
focus
role
DBJDs
therapeutic
potential
natural
products
this
pathway,
offering
novel
insights
prevention
treatment
DBJDs.
