Biotinylated platinum(IV)-conjugated graphene oxide nanoparticles for targeted chemo-photothermal combination therapy in breast cancer DOI
Asif Mohd Itoo, Milan Paul, Naitik Jain

и другие.

Biomaterials Advances, Год журнала: 2024, Номер 168, С. 214121 - 214121

Опубликована: Ноя. 19, 2024

Язык: Английский

Targeting triple negative breast cancer stem cells using nanocarriers DOI Creative Commons
Nagasen Dasari, Girijasankar Guntuku, Sai Kiran S. S. Pindiprolu

и другие.

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Март 7, 2024

Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, treatment responses. Categorization of based on the presence or absence estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), leading to such as luminal A, B, HER2-positive, triple-negative breast (TNBC). TNBC, comprising around 20% all cancers, lacks expression ER, PR, HER2 receptors, rendering it unresponsive targeted therapies presenting significant challenges in treatment. TNBC associated with aggressive behavior, high rates recurrence, resistance chemotherapy. Tumor initiation, progression, are attributed stem cells (BCSCs), which possess self-renewal, differentiation, tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), immune modulation (cytokines, checkpoint inhibitors) among key targets discussed this review. However, targeting BCSC subpopulation presents challenges, including off-target effects, low solubility, bioavailability anti-BCSC agents. Nanoparticle-based offer promising approach target cellular processes implicated survival BSCS TNBC. In review, we explore nanocarrier-based approaches for BCSCs aiming overcome these improve outcomes patients. These nanoparticle-based therapeutic strategies hold promise addressing gap delivering while minimizing systemic toxicity enhancing efficacy. Graphical abstract

Язык: Английский

Процитировано

20

Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro models DOI Creative Commons
Hossein Abolhassani,

Alireza Eskandari,

Anita Saremi Poor

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215754 - 215754

Опубликована: Март 12, 2024

The science of nanotechnology has been proposed as a factor main change in the field cancer diagnosis and treatment. challenges common clinical treatment breast can be dominate by proof targeting cells nanoscale drug delivery system. Due to specific properties nanoparticles such biocompatibility, minimum toxicity, excellent stability, multifunctional encapsulations therapeutic agents, increased permeability retention effect, selective targeting, they apply for therapy. Multidrug resistance many chemotherapy drugs is one conventional that overcome nanoparticles. However, vivo vitro studies limited this field, number approved nano formulation not significantly over years. Successful translation nanomedicines arduous requiring considerable preclinical tests. Two-dimensional (2D) monolayer cell cultures animal models, which are routinely used research discovery/screening seem inadequate. To address challenge, biomimetic three-dimensional (3D) tumor models like spheroids, organoids, scaffolds/hydrogels, bioprinted, microfluidic chips have established using engineering approach. Taking physiopathology microenvironment into account, potential enhance disease modeling drug/nanomedicine screening. development 3D comprised patient's own cancer, stromal, immune exploited promising platform provide personalized

Язык: Английский

Процитировано

15

Implications of nanotherapeutic advancements to leverage multi-drug resistant breast cancer: The state-of-the-art review DOI Creative Commons

Adhithya Aravindan,

Ashutosh Gupta, Sudheer Moorkoth

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 106007 - 106007

Опубликована: Авг. 5, 2024

Globally, cancer is regarded as a severe health issue. Among these breast (BC), the second most common kind in women after skin cancer. According to statistical data from NIH Cancer Institute, expected number of cases was around 3 lakh people, with 7.1 % fatality rate. The rise multidrug resistance (MDR) British Columbia issue it lowers effectiveness existing treatments. Traditional MDR treatment approaches BC have drawbacks, including toxicity, high cost, early discharge, restricted drug load before target, and poor effectiveness. Preventing has depended heavily on developing innovative therapy delivery methods utilizing nanomedicine new diagnosing treating BC. This review discusses its pathophysiology relation tumor kinetics. It focuses latest therapeutic over traditional like Surgery, Chemotherapy, Nanomedicine, Phototherapy, Immunotherapy, Gene therapy. also describes diagnostic techniques using MRI/PET, Mammography, Microwave Sensing, In-silico methods, Molecular techniques, AI-machine learning-based tools. discussed limitations nanoparticles article aims identify efficient ways diagnose treat prevent recurrence.

Язык: Английский

Процитировано

13

Recent advancements in Nanotechnology-Mediated Platinum-Based cancer therapy DOI
Asif Mohd Itoo, Balaram Ghosh, Swati Biswas

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215796 - 215796

Опубликована: Март 17, 2024

Язык: Английский

Процитировано

10

Synergistic Anticancer Effects of Liposomal Doxorubicin and Aprepitant Combination Therapy in Breast Cancer: Preclinical Insights and Therapeutic Potential DOI
Atefeh Ghahremanloo, Fereshteh Asgharzadeh, Fatemeh Gheybi

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106620 - 106620

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2

Chitosan oligosaccharide/pluronic F127 micelles exhibiting anti-biofilm effect to treat bacterial keratitis DOI

Sri Ganga Padaga,

Sanjay Ch,

Milan Paul

и другие.

Carbohydrate Polymers, Год журнала: 2024, Номер 330, С. 121818 - 121818

Опубликована: Янв. 15, 2024

Язык: Английский

Процитировано

6

Functionalized graphene oxide NPs as a nanocarrier for drug delivery system in quercetin/ lurbinectedin as dual sensitive therapeutics for A549 lung cancer treatment DOI Creative Commons

Ruomin Liao,

Yi Zhang, Wenwei Mao

и другие.

Heliyon, Год журнала: 2024, Номер 10(11), С. e31212 - e31212

Опубликована: Май 14, 2024

Functionalized graphene oxide nanoparticles (NPs) have emerged as promising nanocarriers for drug delivery in lung cancer therapy. Quercetin and lurbinectedin encapsulated (GO) NPs are tested treating A549 cells. Spectroscopic analyses show that functionalization creates a transparent, smooth surface loading.Treatment with quercetin/lurbinectedin-loaded GO induces notable cytotoxic effects cells, evidenced by distinct morphological alterations confirmed apoptotic cellular death observed through fluorescence microscopy. Additionally, our study highlights the impact of this approach on metastasis, supported qRT-PCR analysis relative gene expression levels, including p53, Bax, Caspase-3, Bcl2, revealing robust molecular mechanisms underlying therapeutic efficacy against PC9 cell lines. Flow cytometric further confirm induction cells following administration nanoformulation. Our findings may be treatment, opening new avenues targeted effective therapies.

Язык: Английский

Процитировано

6

F127/chlorin e6-nanomicelles to enhance Ce6 solubility and PDT-efficacy mitigating lung metastasis in melanoma DOI
Milan Paul, Balaram Ghosh, Swati Biswas

и другие.

Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown

Опубликована: Май 16, 2024

Язык: Английский

Процитировано

6

Polymeric nanomaterials-based theranostic platforms for triple-negative breast cancer (TNBC) treatment DOI
Sudhakar Reddy Baddam,

Srinivas Ganta,

Seshadri Nalla

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 660, С. 124346 - 124346

Опубликована: Июнь 16, 2024

Язык: Английский

Процитировано

4

The investigation of the interaction of warangalone with transferrin as a therapeutic biological macromolecule and the formation of a protein-ligand nanocomplex with superior anticancer activity against lung cancer cells DOI
Jie Cai,

Si‐qiang Zheng,

Bo Tao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139951 - 139951

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0