Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 10, 2024
Triple-negative
breast
cancer
(TNBC)
stands
as
the
most
complex
and
daunting
subtype
of
affecting
women
globally.
Regrettably,
treatment
options
for
TNBC
remain
limited
due
to
its
clinical
complexity.
However,
immunotherapy
has
emerged
a
promising
avenue,
showing
success
in
developing
effective
therapies
advanced
cases
improving
patient
outcomes.
Improving
treatments
involves
reducing
side
effects,
minimizing
systemic
toxicity,
enhancing
efficacy.
Unlike
traditional
immunotherapy,
engineered
nonmaterial's
can
precisely
target
TNBC,
facilitating
immune
cell
access,
antigen
presentation,
triggering
lasting
responses.
Nanocarriers
with
enhanced
sensitivity
specificity,
specific
cellular
absorption,
low
toxicity
are
gaining
attention.
Nanotechnology-driven
immunoengineering
strategies
focus
on
targeted
delivery
systems
using
multifunctional
molecules
precise
tracking,
diagnosis,
therapy
TNBC.
This
study
delves
into
TNBC's
tumour
microenvironment
(TME)
remodeling,
therapeutic
resistance,
nanotechnology.
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(7), С. 723 - 723
Опубликована: Июль 4, 2024
Breast
cancer
remains
the
most
prevalent
among
women
worldwide,
driving
urgent
need
for
innovative
approaches
to
diagnosis
and
treatment.
This
review
highlights
pivotal
role
of
nanoparticles
in
revolutionizing
breast
management
through
advancements
interconnected
including
targeted
therapy,
imaging,
personalized
medicine.
Nanoparticles,
with
their
unique
physicochemical
properties,
have
shown
significant
promise
addressing
current
treatment
limitations
such
as
drug
resistance
nonspecific
systemic
distribution.
Applications
range
from
enhancing
delivery
systems
sustained
release
developing
diagnostic
tools
early
precise
detection
metastases.
Moreover,
integration
into
photothermal
therapy
synergistic
use
existing
treatments,
immunotherapy,
illustrate
transformative
potential
care.
However,
journey
towards
clinical
adoption
is
fraught
challenges,
chemical
feasibility,
biodistribution,
efficacy,
safety
concerns,
scalability,
regulatory
hurdles.
delves
state
nanoparticle
research,
applications
diagnosis,
obstacles
that
must
be
overcome
integration.
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
249, С. 114504 - 114504
Опубликована: Янв. 9, 2025
Triple-negative
breast
cancer
(TNBC)
is
an
aggressive
form
of
defined
by
the
lack
three
key
receptors:
estrogen,
progesterone,
and
HER2.
This
receptors
makes
TNBC
difficult
to
treat
with
hormone
therapy
or
drugs,
so
it
characterised
a
poor
prognosis
compared
other
kinds
cancer.
study
explores
photoactive
Poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
as
potential
therapeutic
strategy
for
TNBC.
The
are
functionalised
hyaluronic
acid
(HA)
targeted
delivery
CD-44
overexpressed
in
cells,
especially
under
hypoxic
conditions.
Additionally,
we
co-loaded
Doxorubicin
(Dox)
Indocyanine
Green
(ICG)
enable
combinatorial
chemo-photothermal
therapy.
After
carefully
optimising
formulation,
propose
effortless
reproducible
preparation
nanodrugs.
We
demonstrate
that
HA-conjugated
effectively
target
cells
inhibit
their
proliferation
while
treatment
efficiency
enhanced
during
near-infrared
light
irradiation.
also
prove
our
effective
3D
cell
culture
model,
highlighting
importance
tumour
architecture
metabolic
stage
microenvironment.
approach
promising
tumour-targeted
theragnostic
improved
efficacy
microenvironments.
Highlights in Science Engineering and Technology,
Год журнала:
2025,
Номер
126, С. 136 - 141
Опубликована: Янв. 10, 2025
With
the
continuous
development
of
medical
and
materials
science
technologies,
drug
delivery
have
started
transitioning
from
synthetic
to
natural
materials.
Silk
fibroin,
known
for
its
excellent
biocompatibility
drug-loading
capabilities,
has
shown
immense
potential
broad
prospects
in
enhancing
cellular
uptake
rates
tumor
tissue
aggregation
through
construction
nanomaterial
systems,
thereby
improving
resistance
issues
increasing
efficiency
cancer
treatment.
This
paper
summarizes
application
functionalized
silk
fibroin
nanomaterials
field
delivery,
based
on
relevant
domestic
international
research.
It
aims
provide
a
reference
further
in-depth
research
this
area.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
development
of
malignant
tumors
is
a
complex
process
that
involves
the
tumor
microenvironment
(TME).
An
immunosuppressive
TME
presents
significant
challenges
to
current
cancer
therapies,
serving
as
key
mechanism
through
which
cells
evade
immune
detection
and
play
crucial
role
in
progression
metastasis.
This
impedes
optimal
effectiveness
immunotherapeutic
approaches,
including
cytokines,
checkpoint
inhibitors,
vaccines.
Tumor-associated
macrophages
(TAMs),
major
component
tumor-infiltrating
cells,
exhibit
dual
functionalities:
M1-like
TAMs
suppress
tumorigenesis,
while
M2-like
promote
growth
Consequently,
various
nanocarriers
aimed
at
polarizing
phenotypes
distinct
mechanisms
has
emerged
promising
therapeutic
strategy
inhibit
escape
enhance
antitumor
responses.
Review
covers
origin
types
TAMs,
common
pathways
regulating
macrophage
polarization,
progression,
strategies
targeting
aiming
provide
comprehensive
understanding
guidance
for
future
research
clinical
applications.
Future Oncology,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Фев. 12, 2025
Triple-negative
breast
cancer
(TNBC)
presents
a
formidable
global
health
challenge,
marked
by
its
aggressive
behavior
and
significant
treatment
resistance.
This
subtype,
devoid
of
estrogen,
progesterone,
HER2
receptors,
largely
relies
on
stem
cells
(BCSCs)
for
progression,
metastasis,
recurrence.
BCSCs,
characterized
their
self-renewal
capacity
resistance
to
conventional
therapies,
exploit
key
surface
markers
critical
signaling
pathways
like
Wnt,
Hedgehog,
Notch,
TGF-β,
PI3K/AKT/mTOR
Hippo-YAP/TAZ
thrive.
Their
adaptability
is
underscored
mechanisms
including
drug
efflux
enhanced
DNA
repair,
contributing
poor
prognosis
high
recurrence
rates.
The
tumor
microenvironment
(TME)
further
facilitates
BCSC
survival
through
complex
interactions
with
stromal
immune
cells.
Emerging
therapeutic
strategies
targeting
BCSCs
-
ranging
from
immunotherapy
nanoparticle-based
delivery
systems
gene-editing
technologies
aim
disrupt
these
resistant
Additionally,
innovative
approaches
focusing
exosome-mediated
metabolic
reprogramming
show
promise
in
overcoming
chemoresistance.
By
elucidating
the
distinct
characteristics
role
TNBC,
researchers
are
paving
way
novel
treatments
that
may
effectively
eradicate
resilient
cells,
mitigate
ultimately
improve
patient
outcomes.
review
highlights
urgent
need
targeted
address
unique
biology
pursuit
more
effective
interventions
TNBC.
Abstract
Triple-negative
breast
cancer
(TNBC)
is
characterised
by
the
lack
or
low
expression
of
estrogen,
progesterone,
and
human
epidermal
growth
factor
receptor
2
receptors.
TNBC
has
a
high
recurrence
rate,
swiftly
metastasizes,
mortality
rate.
Subsequently,
increase
in
cases
signaled
need
for
treatment
strategies
with
improved
drug
delivery
systems.
New
diagnostic
approaches,
chemical
entities,
formulations
particular
those
nanometric
range
have
emerged
after
extensive
scientific
research
as
alternative
treatment.
As
compared
to
contemporary
therapy,
nanoparticles
offer
peculiar
tunable
features
namely
small
size,
shape,
electrical
charge,
magnetic
fluorescent
properties.
Specifically
targeted
delivery,
been
demonstrated
be
highly
efficient
encapsulating,
functionalization,
conjugation.
Presently,
ignited
transformed
approach
photodynamic
bioimaging,
use
theranostics
precision
medicine
cancer.
Correspondingly,
recent
years
witnessed
drastic
rise
literature
pertaining
using
nanomaterials.
this
manuscript
aims
present
state-of-the-art
nanomaterials
advance
on
treatment;
ubiquitous
utility
such
liposomes,
dendrimers,
solid
lipid
nanomaterials,
gold
quantum
dots
anticancer
agents
systems
TNBC.
