Phenylboronic acid-functionalized biomaterials for improved cancer immunotherapy via sialic acid targeting

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 333, С. 103301 - 103301

Опубликована: Сен. 6, 2024

Язык: Английский

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Co-Delivery of Glycyrrhizin and Paclitaxel via Gelatin-Based Core–Shell Nanoparticles Ameliorates 1,2-Dimethylhydrazine-Induced Precancerous Lesions in Colon

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Colorectal cancer is a lethal malignancy that begins from acquired/inherent premalignant lesions. Thus, targeting these lesions at an early stage of the disease could impede oncogenesis and maximize efficacy. The present work underscores combinatorial therapy paclitaxel (PTX) glycyrrhizin (GL) delivered via gelatin-derived core-shell nanoparticles [AC-PCL(GL + PTX)-GNPs] for effective management precancerous desolvation method was adopted to prepare GL-loaded gelatin (GL-GNPs), which were coated with PTX AC-PCL. prepared NPs exhibited optimal physical attributes had spherical morphology, as analyzed by transmission electron microscopy field-emission scanning microscopy. In vitro release studies revealed sustained ∼96 h. Cell culture in HTC 116, HT-29 cells showed synergistic action CI < 0.9 DRI > 1. Moreover, AC-PCL(GL PTX)-GNPs amplified intracellular uptake thus significantly reduced IC50. Pharmacokinetic substantiated pharmacokinetic parameters (AUC0-∞, Cmax, etc.). vivo 1,2-dimethyl hydrazine-induced model decrease number lesions, mucin depletion, subside infiltrations. An immunohistochemical study elevated expression caspase-9 suppressed VEGF Ki-67. Toxicity insignificant changes systemic biomarkers along no alterations organ morphology hemocompatibility. essence, render competent safer tactic regulate early-stage

Язык: Английский

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Crosslinked hydroxypropyl-β-cyclodextrin nanoparticles for improved efficacy of venetoclax against triple negative breast cancer

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125296 - 125296

Опубликована: Янв. 1, 2025

Язык: Английский

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Dual acting oxaliplatin (IV) prodrug loaded albumin nanoparticles for safer synergistic anticancer action against triple negative breast cancer

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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CD19-targeted HSP90 inhibitor nanoparticle combined with TKIs reduces tumor burden and enhances T-cell immunity in murine B-cell malignancies

Theranostics, Год журнала: 2025, Номер 15(8), С. 3589 - 3609

Опубликована: Фев. 25, 2025

Rationale: Conventional chemotherapies for B-cell malignancies are often limited by drug resistance and significant side effects due to non-specific targeting. This research aimed improve treatment efficacy developing nano-delivery systems that specifically target tumor cells, thereby enhancing therapeutic precision reducing off-target toxicity. Methods: The construction, biocompatibility, targeting capability of CD19@NP/17-DMAG were evaluated using TEM, HPLC, FTIR spectroscopy, CCK-8 assay, flow cytometry (FC), IVIS imaging. Therapeutic was assessed through Western blotting, RT-qPCR, cytometry, H&E staining, BrdU apoptosis assays. mechanism action in murine investigated RNA sequencing, vivo T-cell depletion, CRISPR/Cas9 technology. Results: nanoparticles demonstrated enhanced models BCR-ABL1⁺ acute lymphoblastic leukemia (B-ALL) when combined with tyrosine kinase inhibitors (TKIs), including the BCR-ABL1-targeted imatinib broad-spectrum ponatinib. combination significantly reduced burden, prolonged survival, induced a robust anti-tumor response. RNA-seq analysis indicated targeted modulated genes related cell proliferation, apoptosis, antigen presentation. Notably, this also increased MHC class I (MHC-I) expression, strengthening presentation B-ALL cells. Ponatinib-based therapy achieved complete remission, eradicated minimal residual disease, established long-term immune memory B-ALL. In addition, effective another malignancy model, A20 lymphoma, slowing growth amplifying responses. Conclusions: These findings highlight system as promising approach both augments T responses minimizes malignancies.

Язык: Английский

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Circ_0082374 Promotes the Tumorigenesis and Suppresses Ferroptosis in Non-small Cell Lung Cancer by Up-Regulating GPX4 Through Sequestering miR-491-5p

Molecular Biotechnology, Год журнала: 2024, Номер unknown

Опубликована: Март 4, 2024

Язык: Английский

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Ferroptosis: Molecular perspective, cellular influence, cancer manifestation, and therapeutic potentials

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 105998 - 105998

Опубликована: Июль 31, 2024

Язык: Английский

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Phenylboronic Acid-Modified pH/Glucose Dual-Responsive Polymeric Micelles for Targeted Anticancer Drug Delivery

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

The tumor microenvironment is characterized by several hallmarks such as an acidic pH and high glucose levels in tissues increased expression of specific proteins and/or sugars on the surface cells. These unique tumors can be considered design multifunctional drug delivery nanosystems to improve efficiency therapy through targeted release tissue. In this study, phenylboronic acid-modified pH- glucose-responsive polymer micelles were designed for anticancer drugs. polymeric demonstrated prolonged pH/glucose-triggered enhanced cellular internalization B16F10 cells a receptor-mediated endocytosis pathway. micellar system could inhibit proliferation with IC50 values lower than those unmodified micelles. addition, markedly suppress cell migration, colony formation, invasion promote apoptosis cells, indicating good vitro. Therefore, nanocarrier provides potential platform therapy.

Язык: Английский

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Hyaluronic acid functionalized liposomes for co-delivery of paclitaxel and ursolic acid for enhanced efficacy against triple negative breast cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106451 - 106451

Опубликована: Ноя. 1, 2024

Язык: Английский

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Synergetic approaches of fucoidan and trabectedin complex coated PLGA nanoparticles effectively suppresses proliferation and induce apoptosis for the treatment on non-small cell lung cancer

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер 35(9), С. 1323 - 1342

Опубликована: Март 26, 2024

Traditional methods of treating lung cancer have not been very effective, contributing to the disease's high incidence and death rate. As a result, Fn/Tn-PLGA NPs, novel directed fucoidan trabectedin complex loaded PLGA nanoparticle, were produced investigate role developing therapeutic strategies for NSCLC A549 cell lines. Quantitative real-time polymerase chain reaction was used examine protein expression mRNA expression, respectively. Protein activity knocked down using specific inhibitors short disrupting RNA transfection. Lastly, lines H1299 subjected an in vitro cytotoxicity experiment. Commercial assays assess levels viability, ROS proliferation found that NPs effectively killed cells. To death, annexin flow cytometry employed. In addition, scratch-wound assay conducted migration effects laboratory setting. Finally, covered with mix could be good vehicle targeting cancerous tissues chemotherapeutic drugs.

Язык: Английский

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