International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2507 - 2528
Опубликована: Март 1, 2024
Background:
Cancer
continues
to
be
a
prominent
issue
in
the
field
of
medicine,
as
demonstrated
by
recent
studies
emphasizing
significant
role
autophagy
development
cancer.
Traditional
Chinese
Medicine
(TCM)
provides
variety
anti-tumor
agents
capable
regulating
autophagy.
However,
clinical
application
autophagy-modulating
compounds
derived
from
TCM
is
impeded
their
restricted
water
solubility
and
bioavailability.
To
overcome
this
challenge,
utilization
nanotechnology
has
been
suggested
potential
solution.
Nonetheless,
current
body
literature
on
nanoparticles
delivering
TCM-derived
for
cancer
treatment
limited,
lacking
comprehensive
summaries
detailed
descriptions.
Methods:
Up
November
2023,
research
study
was
conducted
gather
relevant
data
using
databases,
including
PubMed,
ScienceDirect,
Springer
Link,
Web
Science,
CNKI.
The
keywords
utilized
investigation
included
"autophagy",
"nanoparticles",
"traditional
medicine"
"anticancer".
Results:
This
review
analysis
overcoming
delivery
challenges
enhancing
anti-cancer
properties
TCM.
evaluation
based
synthesis
different
classes
TCM,
mechanisms
action
treatment,
benefits
reported
various
scholarly
sources.
findings
indicate
that
shows
availability
thereby
opening
up
plethora
therapeutic
avenues.
Conclusion:
Nanotechnology
enhance
efficacy
traditional
through
regulation
Keywords:
autophagy,
nano-delivery,
anti-cancer,
medicine
Medicinal Research Reviews,
Год журнала:
2023,
Номер
43(4), С. 717 - 774
Опубликована: Фев. 9, 2023
Abstract
Photodynamic
therapy
is
an
alternative
treatment
mainly
for
cancer
but
also
bacterial
infections.
This
dates
back
to
1900
when
a
German
medical
school
graduate
Oscar
Raab
found
photodynamic
effect
while
doing
research
his
doctoral
dissertation
with
Professor
Hermann
von
Tappeiner.
Unexpectedly,
revealed
that
the
toxicity
of
acridine
on
paramecium
depends
intensity
light
in
laboratory.
therefore
based
administration
photosensitizer
subsequent
irradiation
within
absorption
maxima
this
substance
followed
by
reactive
oxygen
species
formation
and
finally
cell
death.
Although
not
novelty,
there
endeavor
various
modifications
therapy.
For
example,
selectivity
efficiency
photosensitizer,
as
well
types
sources
are
still
being
modified
improve
final
results
The
main
aim
review
summarize
anticancer
antibacterial
modifications,
namely
compounds,
approaches,
techniques,
enhance
effectiveness
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(18)
Опубликована: Фев. 19, 2024
The
cell
membrane
is
a
crucial
component
of
cells,
protecting
their
integrity
and
stability
while
facilitating
signal
transduction
information
exchange.
Therefore,
disrupting
its
structure
or
impairing
functions
can
potentially
cause
irreversible
damage.
Presently,
the
tumor
recognized
as
promising
therapeutic
target
for
various
treatment
methods.
Given
extensive
research
focused
on
membranes,
it
both
necessary
timely
to
discuss
these
developments,
from
materials
design
specific
biomedical
applications.
This
review
covers
treatments
based
functional
targeting
membrane,
ranging
well-known
membrane-anchoring
photodynamic
therapy
recent
lysosome-targeting
chimaeras
protein
degradation.
diverse
mechanisms
are
introduced
in
following
sections:
phototherapy,
self-assembly
situ
biosynthesis
degradation
proteins
by
chimeras.
In
each
section,
we
outline
conceptual
general
derived
numerous
studies,
emphasizing
representative
examples
understand
advancements
draw
inspiration.
Finally,
some
challenges
future
directions
membrane-targeted
our
perspective.
aims
engage
multidisciplinary
readers
encourage
researchers
related
fields
advance
fundamental
theories
practical
applications
membrane-targeting
agents.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 16, 2024
Topical
drug
delivery
is
widely
used
in
various
diseases
because
of
the
advantages
not
passing
through
gastrointestinal
tract,
avoiding
irritation
and
hepatic
first-pass
effect,
reaching
lesion
directly
to
reduce
unnecessary
adverse
reactions.
The
skin
helps
organism
defend
itself
against
a
huge
majority
external
aggressions
one
most
important
lines
defense
body.
However,
skin’s
strong
barrier
ability
also
obstacle
effectiveness
topical
medications.
Allowing
bioactive,
composition
pass
stratum
corneum
as
needed
reach
target
site
essential
need
for
exert
its
therapeutic
effect.
state
barrier,
choice
system
composition,
individualized
disease
detection
dosing
planning
influence
Nowadays,
enhancing
transdermal
absorption
topically
applied
drugs
hottest
research
area.
first
improve
all
drugs.
Excessive
enhances
accumulation
at
non-target
sites
occurrence
This
paper
introduces
strategies
from
three
perspectives:
delivery,
describes
current
status
shortcomings
research,
provides
new
directions
ideas
research.
Abstract
Metabolic
interventions
via
targeting
intratumoral
dysregulated
metabolism
pathways
have
shown
promise
in
reinvigorating
antitumor
immunity.
However,
approved
small
molecule
immunomodulators
often
suffer
from
ineffective
response
rates
and
severe
off‐target
toxicity.
ATP
occupies
a
crucial
role
energy
of
components
that
form
the
tumor
microenvironment
(TME)
influences
cancer
immunosurveillance.
Here,
nanocarrier‐assisted
immunometabolic
therapy
strategy
targets
ATP‐adenosine
axis
for
metabolic
reprogramming
TME
is
reported.
An
ecto‐enzyme
(CD39)
antagonist
POM1
AMP‐activated
protein
kinase
(AMPK)
agonist
metformin
are
both
encapsulated
into
cell‐derived
exosomes
used
as
nanocarriers
delivery.
This
method
increases
level
pro‐inflammatory
extracellular
(eATP)
while
preventing
accumulation
immunosuppressive
adenosine
alleviating
hypoxia.
Elevated
eATP
triggers
activation
P2X7‐NLRP3‐inflammasome
to
drive
macrophage
pyroptosis,
potentiates
maturation
antigen
capacity
dendritic
cells
(DCs)
enhance
cytotoxic
function
T
natural
killer
(NK)
cells.
As
result,
synergistic
immune
responses
initiated
suppress
progress,
inhibit
distant
metastases,
provide
long‐term
memory
offers
protection
against
recurrence
overcome
anti‐PD1
resistance.
Overall,
this
study
provides
an
innovative
advance
eATP‐driven
immunity
therapy.
Abstract
Despite
the
clinical
potential,
photodynamic
therapy
(PDT)
relying
on
singlet
oxygen
(
1
O
2
)
generation
is
severely
limited
by
tumor
hypoxia
and
endosomal
entrapment.
Herein,
a
proton‐driven
transformable
‐nanotrap
(ANBDP
NPs)
with
escape
capability
presented
to
improve
hypoxic
PDT.
In
acidic
environment,
protonated
ruptures
membranes
via
“proton‐sponge”
like
effect
undergoes
drastic
morphology‐and‐size
change
from
nanocubes
(≈94.1
nm
in
length)
nanospheres
(≈12.3
diameter).
Simultaneously,
anthracenyl
boron
dipyrromethene‐derived
photosensitizer
(ANBDP)
transforms
its
form
(ANBDPH)
switches
off
charge‐transfer
state
achieve
amplified
photogeneration
capability.
Upon
730
photoirradiation,
ANBDPH
prominently
produces
traps
generated‐
anthracene
group
endoperoxide
(ANOBDPH).
Benefitting
hypoxia‐tolerant
‐release
property
of
ANOBDPH
dark,
brings
about
sustained
therapeutic
without
further
continuous
irradiation,
thereby
achieving
remarkable
antitumor
performance.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(37)
Опубликована: Март 3, 2022
Abstract
In
order
to
cure
diseases
efficiently
with
minimal
side
effects
in
sophisticated
medicine,
eminent
drugs
must
be
selectively
delivered
diseased
parts
and
allow
work
only
there.
However,
most
of
drug
delivery
systems
(DDSs)
previously
proposed
are
not
yet
sufficiently
selective
effective.
This
review
covers
recent
developments
DDS
which
DNA
nanoarchitectures
employed
as
carriers.
From
short
fragments,
a
variety
complicated
nanomedicines
fabricated
show
unprecedentedly
smart
functions.
Encapsulated
released
mostly
through
controlled
disassembly
nanoarchitectures.
Recent
attention
has
been
focusing
the
use
appropriate
stimuli
regulate
each
process
(delivery
drug,
its
release,
others)
for
further
improved
therapy.
As
intracellular
regulation,
various
endogenous
compounds
(e.g.,
mRNA
enzymes),
specifically
abundant
target
cells,
employed.
Alternatively,
physical
perturbation
light
irradiation)
is
provided
from
outside
tissues
control
DDS.
By
combining
multiple
strategies
terms
new
concepts,
enormously
DDSs
being
achieved.
Further
progresses
these
approaches
future
guaranteed
by
complete
freedom
molecular
design
nanoarchitectonics.
