ACS Nano,
Год журнала:
2024,
Номер
18(9), С. 7204 - 7222
Опубликована: Фев. 19, 2024
Commercial
collagen
membranes
face
difficulty
in
guided
bone
regeneration
(GBR)
due
to
the
absence
of
hierarchical
structural
design,
effective
interface
management,
and
diverse
bioactivity.
Herein,
a
Janus
membrane
called
SrJM
is
developed
that
consists
porous
enhance
osteogenic
function
dense
maintain
barrier
function.
Specifically,
biomimetic
intrafibrillar
mineralization
with
strontium
apatite
realized
by
liquid
precursors
amorphous
phosphate.
Polycaprolactone
methacryloyl
further
integrated
on
one
side
as
face,
which
endows
mechanical
support
prolonged
lifespan.
In
vitro
experiments
demonstrate
acts
strong
against
fibroblasts,
while
significantly
promotes
cell
adhesion
differentiation
through
activation
calcium-sensitive
receptor/integrin/Wnt
signaling
pathways.
Meanwhile,
effectively
enhances
osteogenesis
angiogenesis
recruiting
stem
cells
modulating
osteoimmune
response,
thus
creating
an
ideal
microenvironment
for
regeneration.
vivo
studies
verify
defect
region
completely
repaired
newly
formed
vascularized
bone.
Overall,
outstanding
performance
supports
its
ongoing
development
multifunctional
GBR
membrane,
this
study
provides
versatile
strategy
fabricating
collagen-based
biomaterials
hard
tissue
The
rapid
degradation
of
magnesium
(Mg)
alloy
implants
erodes
mechanical
performance
and
interfacial
bioactivity,
thereby
limiting
their
clinical
utility.
Surface
modification
is
among
the
solutions
to
improve
corrosion
resistance
bioefficacy
Mg
alloys.
Novel
composite
coatings
that
incorporate
nanostructures
create
new
opportunities
for
expanded
use.
Particle
size
dominance
impermeability
may
increase
prolong
implant
service
time.
Nanoparticles
with
specific
biological
effects
be
released
into
peri-implant
microenvironment
during
promote
healing.
Composite
nanocoatings
provide
nanoscale
surfaces
cell
adhesion
proliferation.
activate
cellular
signaling
pathways,
while
those
porous
or
core-shell
structures
carry
antibacterial
immunomodulatory
drugs.
vascular
reendothelialization
osteogenesis,
attenuate
inflammation,
inhibit
bacterial
growth,
thus
increasing
applicability
in
complex
microenvironments
such
as
atherosclerosis
open
fractures.
This
review
combines
physicochemical
properties
efficiency
Mg-based
biomedical
summarize
advantages
nanocoatings,
analyzes
mechanisms
action,
proposes
design
construction
strategies,
purpose
providing
a
reference
promoting
application
further
nanocoatings.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(16)
Опубликована: Янв. 17, 2023
Abstract
Driving
endogenous
bone
regeneration
by
cell‐
and
factor‐free
biomaterials
is
the
most
ideal
repair
strategy.
Herein,
hybrid
interleaved
scaffold
(HDSH)
with
nanosized
interfacial
integration
assembled
organic/inorganic
interactive
bonding
at
nanoscale.
With
help
of
transcriptome
proteome
analysis,
regenerative
mechanism
this
elaborated
molecular
level,
which
confirms
that
strategy
recreates
a
suitable
immune
microenvironment
(anti‐inflammatory
M2‐polarizing)
drives
functional
cell
cytokine
adhesion,
as
well
inchoate
vascularization.
It
greatly
enhances
stem
recruitment,
subsequently
initiates
robust
vasculogenesis
osteogenesis.
Significant
bony
reconstitution
in
rabbit
cranial
defect
model
(Φ
=
10
mm)
observed
after
12
weeks,
realizes
completely
new
coverage
79%
breaking
load
strength
relative
to
natural
cranium.
By
enhancing
nano‐sized
integration,
can
provide
effective
guidance
for
developing
highly
bioactive
bone‐regenerative
implants.
Abstract
Osteoarthritis
(OA)
is
a
chronic
disease
that
causes
pain
and
disability
in
adults,
affecting
≈300
million
people
worldwide.
It
caused
by
damage
to
cartilage,
including
cellular
inflammation
destruction
of
the
extracellular
matrix
(ECM),
leading
limited
self‐repairing
ability
due
lack
blood
vessels
nerves
cartilage
tissue.
Organoid
technology
has
emerged
as
promising
approach
for
repair,
but
constructing
joint
organoids
with
their
complex
structures
special
mechanisms
still
challenging.
To
overcome
these
boundaries,
3D
bioprinting
allows
precise
design
physiologically
relevant
organoids,
shape,
structure,
mechanical
properties,
arrangement,
biological
cues
mimic
natural
In
this
review,
authors
will
introduce
structure
tissues,
summarize
key
procedures
propose
strategies
using
bioprinting.
The
also
discuss
challenges
organoids’
approaches
perspectives
on
future
applications,
opening
opportunities
model
tissues
response
treatment.
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100834 - 100834
Опубликована: Окт. 20, 2023
Achieving
precision
treatment
in
bone
tissue
engineering
(BTE)
remains
a
challenge.
Photothermal
therapy
(PTT),
as
form
of
therapy,
has
been
extensively
investigated
for
its
safety
and
efficacy.
It
demonstrated
significant
potential
the
orthopedic
diseases
such
tumors,
postoperative
infections
osteoarthritis.
However,
high
temperatures
associated
with
PTT
can
lead
to
certain
limitations
drawbacks.
In
recent
years,
researchers
have
explored
use
biomaterials
mild
photothermal
(MPT),
which
offers
promising
approach
addressing
these
limitations.
This
review
provides
comprehensive
overview
mechanisms
underlying
MPT
presents
compilation
agents
their
utilization
strategies
repair.
Additionally,
paper
discusses
future
prospects
MPT-assisted
regeneration,
aiming
provide
insights
recommendations
optimizing
material
design
this
field.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 16, 2024
Platelet-rich
fibrin,
a
classical
autologous-derived
bioactive
material,
consists
of
fibrin
scaffold
and
its
internal
loading
growth
factors,
platelets,
leukocytes,
with
the
gradual
degradation
slow
release
physiological
doses
factors.
PRF
promotes
vascular
regeneration,
proliferation
migration
osteoblast-related
cells
such
as
mesenchymal
cells,
osteoblasts,
osteoclasts
while
having
certain
immunomodulatory
anti-bacterial
effects.
has
excellent
osteogenic
potential
been
widely
used
in
field
bone
tissue
engineering
dentistry.
However,
there
are
still
some
limitations
PRF,
improvement
biological
properties
is
one
most
important
issues
to
be
solved.
Therefore,
it
often
combined
scaffolds
enhance
mechanical
delay
degradation.
In
this
paper,
we
present
systematic
review
development
platelet-rich
derivatives,
structure
mechanisms,
applications,
optimization
broaden
their
clinical
applications
provide
guidance
for
translation.
Biomimetics,
Год журнала:
2024,
Номер
9(4), С. 230 - 230
Опубликована: Апрель 12, 2024
Osteoporosis
is
a
skeletal
disorder
marked
by
compromised
bone
integrity,
predisposing
individuals,
particularly
older
adults
and
postmenopausal
women,
to
fractures.
The
advent
of
bioceramics
for
regeneration
has
opened
up
auspicious
pathways
addressing
osteoporosis.
Research
indicates
that
can
help
bones
grow
back
activating
morphogenetic
protein
(BMP),
mitogen-activated
kinase
(MAPK),
wingless/integrated
(Wnt)/β-catenin
in
the
body
when
combined
with
stem
cells,
drugs,
other
supports.
Still,
have
some
problems,
such
as
not
being
flexible
enough
prone
breaking,
well
difficulties
growing
cells
discovering
suitable
supports
different
types.
While
there
been
improvements
making
better
healing
bones,
it
important
keep
looking
new
ideas
from
areas
medicine
make
them
even
better.
By
conducting
thorough
scrutiny
pivotal
role
play
facilitating
regeneration,
this
review
aspires
propel
forward
rapidly
burgeoning
domain
scientific
exploration.
In
end,
appreciation
will
contribute
development
novel
enhance
regrowth
offer
patients
disorders
alternative
treatments.
Osteoporosis
is
a
bone
condition
where
bones
become
weaker,
leading
to
fractures,
especially
in
older
adults
and
postmenopausal
women.
Bioceramics
for
regeneration
have
indeed
emerged
as
promising
solution
conditions
like
osteoporosis.
Choosing
the
right
bioceramic
depends
on
how
quickly
it
dissolves,
strong
is,
whether
body
will
react
it.
Studies
show
that
bioceramics
can
help
grow
back
by
activating
(bone
morphogenetic
protein)
BMP,
(mitogen-activated
protein
kinase)
MAPK,
Wingless/integrated
(Wnt)/β-catenin
pathways
when
combined
with
stem
cells,
drugs,
supports.
However,
some
problems
not
being
flexible
enough
prone
breaking,
well
difficulties
growing
cells
finding
supports
different
types.
While
there
has
been
progress
improving
healing,
we
need
keep
looking
new
ideas
from
other
areas
of
medicine
them.
This
review
aims
add
expanding
field
scientific
research
offering
detailed
look
at
growth
factors
contribute
regeneration.
Ultimately,
this
knowledge
creating
types
improve
regrowth,
providing
treatment
options
people
diseases.
