Small Structures,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Topical
instillation
of
cyclosporin
A
(an
anti‐inflammatory
drug)
is
clinically
recommended
as
the
first‐line
treatment
for
dry
eye
disease.
Nevertheless,
it
suffers
from
poor
ocular
drug
retention
and
cannot
comprehensively
address
corneal
dryness‐related
symptoms
such
oxidative
stress,
angiogenesis,
neurodegeneration.
Inspired
by
nanotechnology‐mediated
material/biological
interactions,
in
this
study,
a
highly
adhesive
metallic
nanoplatform
with
an
urchin‐like
structure
designed
topical
quercetin
administration
therapy.
The
gold
nanostructures
most
pronounced
branch
lengths
exhibit
strongest
cytoadhesion
bioadhesion
capabilities,
which
significantly
enhance
nano‐urchins
150‐fold
at
7
days
post‐instillation
compared
smooth‐surfaced
nanoparticles.
In
rabbit
model
dryness,
single‐dose
nanoformulation
(high
quercetin‐functionalized
(NU‐Q(H)))
demonstrated
remarkable
efficacy
stimulating
tear
production
(30‐fold
improvement),
inhibiting
inflammatory
IL‐6
expression
(49‐fold
attenuating
pathological
angiogenesis
(32‐fold
promoting
nerve
regeneration
(18‐fold
improvement)
to
high
nanoparticles
(NP‐Q(H)).
particular,
integrity
surface,
film,
meibomian
gland
restored
levels
similar
those
healthy
rabbits.
These
findings
suggest
promising
potential
nanobiomaterial
structural
engineering
developing
nanomedicines
long‐acting
eye‐drop
formulations
disease
applications.
Materials Horizons,
Год журнала:
2024,
Номер
11(18), С. 4367 - 4377
Опубликована: Янв. 1, 2024
The
degradability
of
hydrogels
plays
a
pivotal
role
in
bone
regeneration,
yet
its
precise
effects
on
the
repair
process
remain
poorly
understood.
Traditional
studies
have
been
limited
by
use
with
insufficient
variation
degradation
properties
for
thorough
comparative
analysis.
Addressing
this
gap,
our
study
introduces
development
matrix
metalloproteinase
(MMP)-responsive
engineered
tunable
rate,
specifically
designed
regeneration
applications.
These
innovative
are
synthesized
integrating
MMP-sensitive
peptides,
which
exhibit
chirality-transferred
amino
acids,
norbornene
(NB)-modified
8-arm
polyethylene
glycol
(PEG)
macromers
to
form
hydrogel
network.
behavior
these
is
manipulated
through
chirality
incorporated
resulting
classification
into
L,
LD,
and
D
hydrogels.
Remarkably,
L
variant
shows
significantly
enhanced
both
Abstract
Over
the
past
decade,
precision
medicine
has
garnered
increasing
attention,
making
significant
strides
in
discovering
new
therapeutic
drugs
and
mechanisms,
resulting
notable
achievements
symptom
alleviation,
pain
reduction,
extended
survival
rates.
However,
limited
target
specificity
of
primary
inter‐individual
differences
have
often
necessitated
high‐dosage
strategies,
leading
to
challenges
such
as
restricted
deep
tissue
penetration
rates
systemic
side
effects.
Material
science
advancements
present
a
promising
avenue
for
these
issues.
By
leveraging
distinct
internal
features
diseased
regions
application
specific
external
stimuli,
responsive
materials
can
be
tailored
achieve
targeted
delivery,
controllable
release,
biochemical
reactions.
This
review
aims
highlight
latest
stimuli‐responsive
their
potential
medicine.
Initially,
we
introduce
disease‐related
stimuli
capable
elucidating
reaction
principles
functional
groups.
Subsequently,
provide
detailed
analysis
representative
pre‐clinical
across
various
clinical
applications,
including
enhancements
treatment
cancers,
injury
diseases,
inflammatory
infection
high‐throughput
microfluidic
biosensors.
Finally,
discuss
some
challenges,
off‐target
effects,
long‐term
impacts
nano‐materials,
ethical
concerns,
offer
insights
into
future
perspectives
materials.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1311 - 1311
Опубликована: Фев. 4, 2025
Mesenchymal
stem
cells
(MSCs)
are
crucial
for
skeletal
development,
homeostasis,
and
repair,
primarily
through
their
differentiation
into
osteoblasts
other
lineage
cells.
Key
signaling
pathways,
including
Wnt,
TGF-β/BMP,
PTH,
Hedgehog,
IGF,
act
as
critical
regulators
of
MSC
osteogenesis,
playing
pivotal
roles
in
maintaining
bone
homeostasis
facilitating
regeneration.
These
pathways
interact
distinct
ways
at
various
stages
mineralization,
remodeling.
This
review
provides
an
overview
the
molecular
mechanisms
by
which
these
regulate
influence
on
tissue
formation,
implications
diseases
therapeutic
strategies.
Additionally,
we
explore
potential
applications
engineering,
with
a
particular
focus
promoting
use
MSCs
seed
defect
repair.
Ultimately,
this
aims
to
highlight
avenues
advancing
biology
research,
treating
disorders,
enhancing
regenerative
medicine.
Tissue Engineering and Regenerative Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Abstract
Background:
Periodontitis
and
bone
loss
in
the
maxillofacial
dental
areas
pose
considerable
challenges
for
both
functional
aesthetic
outcomes.
To
date,
implantable
barrier
membranes,
designed
to
prevent
epithelial
migration
into
defects
create
a
favorable
environment
targeted
cells,
have
garnered
significant
interest
from
researchers.
Consequently,
variety
of
materials
fabrication
methods
been
explored
extensive
research
on
regenerative
membranes.
Methods:
This
review
focuses
summarizing
various
biomaterials
used
membrane
manufacturing,
methods,
state-of-the-art
applications
tissue
regeneration.
Based
discussion
pros
cons
current
strategies,
future
directions
improved
designs
are
proposed.
Results
conclusion:
endow
membranes
with
biological
properties
that
accommodate
different
clinical
situations,
numerous
manufacturing
These
approaches
provide
theoretical
support
hold
promise
advancements
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 4, 2025
Metallic
scaffolds
have
shown
promise
in
regenerating
critical
bone
defects.
However,
limitations
persist
achieving
a
modulus
below
100
MPa
due
to
insufficient
strength.
Consequently,
the
osteogenic
impact
of
lower
and
greater
tissue
strain
(
>
1%)
remains
unclear.
Here,
we
introduce
metamaterial
scaffold
that
decouples
strength
through
two-stage
deformation.
The
facilitates
an
effective
only
13
MPa,
ensuring
adaptability
during
regeneration.
Followed
by
stiff
stage,
it
provides
necessary
for
load-bearing
requirements.
In
vivo,
induces
2%
callus
strain,
upregulating
calcium
channels
HIF-1α
enhance
osteogenesis
angiogenesis.
4-week
histomorphology
reveals
44%
498%
increase
new
fraction
versus
classic
with
500
modulus,
respectively.
This
design
transcends
traditional
modulus-matching
paradigms,
prioritizing
Its
tunable
mechanical
properties
also
present
promising
implications
advancing
mechanisms
addressing
clinical
challenges.
Materials Today Bio,
Год журнала:
2023,
Номер
21, С. 100717 - 100717
Опубликована: Июнь 27, 2023
Bone
defects
induced
by
bone
trauma,
tumors
and
osteoarthritis
greatly
affect
the
life
quality
health
of
patients.
The
biomaterials
with
numerous
advantages
are
becoming
most
preferred
options
for
repairing
treating
orthopedic
diseases.
However,
their
effects
remains
unsatisfactory,
especially
in
suffering
from
tumor,
inflammation,
and/or
bacterial
infection.
There
several
strategies
to
functionalize
biomaterials,
but
a
more
general
efficient
method
is
essential
accomplishing
functionalization
biomaterials.
Possessing
high
specific
surface,
porosity,
controlled
degradability
variable
composition,
metal-organic
frameworks
(MOFs)
materials
inherently
advantageous
functionalizing
tremendous
improvements
having
been
achieved.
This
review
summarizes
recent
progresses
MOFs
functionalized
promoting
repair
therapeutic
effects.
In
specific,
utilizing
various
properties
diverse
materials,
integrated
achieve
enhanced
regeneration,
antibacterial,
anti-inflammatory
anti-tumor
functions.
Finally,
summary
prospects
on
development
MOFs-functionalized
were
discussed.
MedComm – Biomaterials and Applications,
Год журнала:
2023,
Номер
2(2)
Опубликована: Июнь 1, 2023
Abstract
Hydroxyapatite
(HA)
bioceramics
have
been
extensively
employed
as
bone
tissue
scaffolds
owing
to
their
biodegradability
and
osteoinductivity.
In
our
work,
HA,
a
significant
component
of
natural
used
the
raw
material
produce
porous
employing
three‐dimensional
(3D)‐printing
technology.
Physical
chemical
properties,
porosity,
compression
resistance
were
investigated
in
vitro.
The
scaffold
was
confirmed
large
number
interconnected
pore
structures
on
surface
inside
HA
showed
good
cell
compatibility
adhesion
text.
To
analyze
effect
repair
regeneration
vivo,
large‐size
defect
beagle
skull
repaired
with
3D
printing
group
an
autologous
(ABG)
for
8
months.
Images
histological
analysis
indicated
better
integration
adjacent
tissues.
However,
there
obvious
gaps
ABG,
which
indicates
weak
ability
this
due
unmatched
implant
dimension.
Immunohistochemistry
immunofluorescence
results
that
3D‐printed
had
highly
vascularized
structure.
This
study
are
osteoinductivity
biodegradable
great
potential
maxillofacial
regeneration.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(2), С. 46 - 46
Опубликована: Фев. 17, 2024
The
additive
manufacturing
of
titanium–niobium–tantalum
alloys
with
nominal
chemical
compositions
Ti–xNb–6Ta
(x
=
20,
27,
35)
by
means
laser
beam
powder
bed
fusion
is
reported,
and
their
potential
as
implant
materials
elaborated
mechanical
biological
characterization.
properties
dense
specimens
manufactured
in
different
build
orientations
open
porous
Ti–20Nb–6Ta
are
evaluated.
Compression
tests
indicate
that
strength
elasticity
influenced
the
composition
orientation.
minimum
always
observed
90°
It
lowest
for
(43.2
±
2.7
GPa)
can
be
further
reduced
to
8.1
1.0
GPa
(p
<
0.001).
Furthermore,
human
osteoblasts
cultivated
7
14
days
on
as-printed
response
compared
Ti–6Al–4V.
Build
orientation
cultivation
time
significantly
affect
gene
expression
profile
osteogenic
differentiation
markers.
Incomplete
cell
spreading
0°
orientation,
whereas
widely
stretched
cells
i.e.,
parallel
direction.
Compared
Ti–6Al–4V,
Ti–Nb–Ta
promote
improved
osteogenesis
reduce
induction
inflammation.
Accordingly,
have
favorable
great
application
orthopedic
implants.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2512 - 2512
Опубликована: Фев. 21, 2024
Bone
differentiation
is
crucial
for
skeletal
development
and
maintenance.
Its
dysfunction
can
cause
various
pathological
conditions
such
as
rickets,
osteoporosis,
osteogenesis
imperfecta,
or
Paget's
disease.
Although
traditional
two-dimensional
cell
culture
systems
have
contributed
significantly
to
our
understanding
of
bone
biology,
they
fail
replicate
the
intricate
biotic
environment
tissue.
Three-dimensional
(3D)
spheroid
cultures
gained
widespread
popularity
addressing
defects.
This
review
highlights
advantages
employing
3D
investigate
differentiation.
It
their
capacity
mimic
complex
in
vivo
cellular
interactions
pivotal
homeostasis.
The
exploration
models
research
offers
enhanced
physiological
relevance,
improved
predictive
capabilities,
reduced
reliance
on
animal
models,
which
advancement
safer
more
effective
strategies
drug
development.
Studies
highlighted
transformative
potential
expanding
biology
developing
targeted
therapeutic
interventions
bone-related
disorders.
explores
how
demonstrated
promise
unraveling
mechanisms
governing
homeostasis
responses
pharmacological
agents.
