Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 13, 2024
Owing
to
the
increased
tissue
iron
accumulation
in
patients
with
diabetes,
microorganisms
may
activate
high
expression
of
iron-involved
metabolic
pathways,
leading
exacerbation
bacterial
infections
and
disruption
systemic
glucose
metabolism.
Therefore,
an
on-demand
transdermal
dosing
approach
that
utilizes
homeostasis
regulation
combat
antimicrobial
resistance
is
a
promising
strategy
address
challenges
associated
low
administration
bioavailability
antibiotic
treating
infected
diabetic
wounds.
Here,
it
aimed
propose
effective
therapy
based
on
hemoglobin
bionics
induce
disturbances
homeostasis.
The
preferred
"iron
cargo"
synthesized
by
protoporphyrin
IX
chelated
dopamine
gallium
(PDGa),
delivered
via
glucose/pH-responsive
microneedle
bandage
(PDGa@GMB).
PDGa@GMB
downregulates
levels
uptake
regulator
(Fur)
peroxide
response
(perR)
Staphylococcus
aureus,
nutrient
starvation
oxidative
stress,
ultimately
suppressing
iron-dependent
activities.
Consequently,
demonstrates
insusceptibility
genetic
while
maintaining
sustainable
effects
(>90%)
against
resistant
strains
both
S.
aureus
E.
coli,
accelerates
recovery
(<20
d).
Overall,
not
only
counteracts
but
also
holds
tremendous
potential
mediating
microbial-host
crosstalk,
synergistically
attenuating
pathogen
virulence
pathogenicity.
Bioelectronic Medicine,
Год журнала:
2023,
Номер
9(1)
Опубликована: Авг. 2, 2023
The
fourth
industrial
revolution
has
led
to
the
development
and
application
of
health
monitoring
sensors
that
are
characterized
by
digitalization
intelligence.
These
have
extensive
applications
in
medical
care,
personal
management,
elderly
sports,
other
fields,
providing
people
with
more
convenient
real-time
services.
However,
these
face
limitations
such
as
noise
drift,
difficulty
extracting
useful
information
from
large
amounts
data,
lack
feedback
or
control
signals.
artificial
intelligence
provided
powerful
tools
algorithms
for
data
processing
analysis,
enabling
intelligent
monitoring,
achieving
high-precision
predictions
decisions.
By
integrating
Internet
Things,
intelligence,
sensors,
it
becomes
possible
realize
a
closed-loop
system
functions
collection,
online
diagnosis,
treatment
recommendations.
This
review
focuses
on
healthcare
enhanced
technologies
aspects
materials,
device
structure,
integration,
scenarios.
Specifically,
this
first
introduces
great
advances
wearable
respiration
rate,
heart
pulse,
sweat,
tears;
implantable
cardiovascular
nerve
signal
acquisition,
neurotransmitter
monitoring;
soft
electronics
precise
therapy.
Then,
recent
volatile
organic
compound
detection
highlighted.
Next,
current
developments
human-machine
interfaces,
AI-enhanced
multimode
self-sustainable
systems
reviewed.
Last,
perspective
future
directions
further
research
is
also
provided.
In
summary,
fusion
will
provide
intelligent,
convenient,
secure
services
next-generation
biomedical
applications.
Acne
is
an
inflammatory
skin
disease
mainly
caused
by
Propionibacterium
acnes,
which
can
cause
local
reactions
and
develop
into
chronic
diseases
in
severe
cases.
To
avoid
the
use
of
antibiotics
to
effectively
treat
site
acne,
we
report
a
sodium
hyaluronate
microneedle
patch
that
mediates
transdermal
delivery
ultrasound-responsive
nanoparticles
for
effective
treatment
acne.
The
contains
formed
zinc
porphyrin-based
metal-organic
framework
oxide
(ZnTCPP@ZnO).
We
demonstrated
activated
oxygen-mediated
killing
P.
acnes
with
antibacterial
efficiency
99.73%
under
15
min
ultrasound
irradiation,
resulting
decrease
levels
acne-related
factors,
including
tumor
necrosis
factor-α,
interleukins,
matrix
metalloproteinases.
ions
up-regulated
DNA
replication-related
genes,
promoting
proliferation
fibroblasts
and,
consequently,
repair.
This
research
leads
highly
strategy
acne
through
interface
engineering
response.
Chemical Reviews,
Год журнала:
2024,
Номер
124(3), С. 768 - 859
Опубликована: Янв. 19, 2024
Optoelectronic
devices
with
unconventional
form
factors,
such
as
flexible
and
stretchable
light-emitting
or
photoresponsive
devices,
are
core
elements
for
the
next-generation
human-centric
optoelectronics.
For
instance,
these
deformable
can
be
utilized
closely
fitted
wearable
sensors
to
acquire
precise
biosignals
that
subsequently
uploaded
cloud
immediate
examination
diagnosis,
also
used
vision
systems
human-interactive
robotics.
Their
inception
was
propelled
by
breakthroughs
in
novel
optoelectronic
material
technologies
device
blueprinting
methodologies,
endowing
flexibility
mechanical
resilience
conventional
rigid
devices.
This
paper
reviews
advancements
soft
technologies,
honing
on
various
materials,
manufacturing
techniques,
design
strategies.
We
will
first
highlight
general
approaches
fabrication,
including
appropriate
selection
substrate,
electrodes,
insulation
layers.
then
focus
materials
diodes,
their
integration
strategies,
representative
application
examples.
Next,
we
move
photodetectors,
highlighting
state-of-the-art
fabrication
methods,
followed
At
end,
a
brief
summary
given,
potential
challenges
further
development
of
functional
discussed
conclusion.
Big Data and Cognitive Computing,
Год журнала:
2023,
Номер
7(3), С. 147 - 147
Опубликована: Авг. 30, 2023
The
future
of
innovative
robotic
technologies
and
artificial
intelligence
(AI)
in
pharmacy
medicine
is
promising,
with
the
potential
to
revolutionize
various
aspects
health
care.
These
advances
aim
increase
efficiency,
improve
patient
outcomes,
reduce
costs
while
addressing
pressing
challenges
such
as
personalized
need
for
more
effective
therapies.
This
review
examines
major
robotics
AI
pharmaceutical
medical
fields,
analyzing
advantages,
obstacles,
implications
In
addition,
prominent
organizations
research
institutions
leading
way
these
technological
advancements
are
highlighted,
showcasing
their
pioneering
efforts
creating
utilizing
state-of-the-art
solutions
medicine.
By
thoroughly
current
state
care
exploring
possibilities
further
progress,
this
work
aims
provide
readers
a
comprehensive
understanding
transformative
power
evolution
healthcare
sector.
Striking
balance
between
embracing
technology
preserving
human
touch,
investing
R&D,
establishing
regulatory
frameworks
within
ethical
guidelines
will
shape
systems.
seamless
integration
systems
benefit
patients
providers.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(18)
Опубликована: Март 17, 2023
Abstract
Managing
slow‐healing
wounds
and
associated
complications
is
challenging,
time‐consuming,
expensive.
Systematic
collection,
analysis,
dissemination
of
correct
wound
status
data
are
critical
for
enhancing
healing
outcomes
reducing
complications.
However,
traditional
collection
approaches
often
neither
accurate
nor
user‐friendly
require
diverse
skill
levels,
resulting
in
the
inconsistent
unreliable
data.
As
an
advancement
to
authors'
previously
developed
hydrogel‐based
smart
dressing,
here
reported
enhanced
integration
drug
delivery
sensing
(pH
glucose)
modules
accelerated
treatment
continuous
monitoring
cutaneous
wounds.
In
current
study,
growth
factor
array
colorimetric
glucose
sensors
incorporated
into
dressing
promote
extend
dressing's
utility
diabetic
treatment.
Furthermore,
efficacy
infection
supporting
via
antibiotic
investigated
mice
models.
The
updated
reveals
excellent
benefits
on
non‐infected
infected
wounds,
as
well
real‐time
early
detection
infection.
ACS Sensors,
Год журнала:
2024,
Номер
9(5), С. 2567 - 2574
Опубликована: Май 2, 2024
In
vivo
drug
monitoring
is
crucial
for
evaluating
the
effectiveness
and
safety
of
treatment.
Blood
sampling
analysis
current
gold
standard
but
needs
professional
skills
cannot
meet
requirements
point-of-care
testing.
Dermal
interstitial
fluid
(ISF)
showed
great
potential
to
replace
blood
in
monitoring;
however,
detection
was
challenging,
distribution
behavior
ISF
still
unclear
until
now.
this
study,
we
proposed
surface-enhanced
Raman
spectroscopy
(SERS)
microneedles
(MNs)
painless
real-time
drugs
after
intravenous
injection.
Using
methylene
blue
(MB)
mitoxantrone
(MTO)
as
model
drugs,
innovative
core–satellite
structured
Au@Ag
SERS
substrate,
hydrogel
coating
over
MNs,
rendered
sensitive
quantitative
mice
within
10
min.
Based
on
technique,
pharmacokinetics
two
investigated
compared
with
those
blood,
where
were
analyzed
via
liquid
chromatography–mass
spectrometry.
It
found
that
MB
concentration
comparable,
whereas
MTO
2–3
orders
magnitude
lower
than
blood.
This
work
an
efficient
tool
monitoring.
More
importantly,
it
experimentally
proved
penetration
ratio
drug-dependent,
providing
insightful
information
into
a
alternative
detection.
Communications Materials,
Год журнала:
2024,
Номер
5(1)
Опубликована: Апрель 11, 2024
Abstract
Wearable
skin-contacting
devices
are
extensively
studied
for
their
ability
to
provide
convenient
and
safe
health
monitoring.
A
key
aspect
that
controls
performance
the
properties
of
device
electrodes.
Optimizing
electrode
structure,
materials
they
made
from,
can
improve
functionality.
Here,
we
discuss
various
required
optimal
performance,
including
mechanical,
electrical,
biocompatible
factors.
To
address
these
challenges,
consider
alteration
development
flexible
or
soft
conductive
materials,
creation
hybrid
structures.
Additionally,
integration
artificial
intelligence
is
proposed
as
a
promising
direction
achieve
smart
devices.
As
well
outlining
essential
characteristics
high-performance
wearable
skin
also
offer
insight
into
possible
future
applications.
