Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 686, С. 133421 - 133421
Опубликована: Фев. 10, 2024
Язык: Английский
Engineering, Год журнала: 2023, Номер unknown
Опубликована: Июнь 1, 2023
Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to site lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are different kinds (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) treating various disorders, including superficial tumors, wounds, infections, inflammatory diseases, abnormal appearance. The improved by integrating advantages multiple perform combination therapy. Through careful designing, further modified with biomimetic structures responsive drug release from internal external stimuli enhance transdermal delivery efficiency robust outcomes. Some studies have proposed use drug-free a promising mechanotherapeutic strategy promote wound healing, scar removal, hair regeneration via mechanical communication pathway. Although several advantages, practical application suffers problems related industrial manufacture clinical evaluation, making it difficult translation. In this study, we summarized applications, emerging challenges, developmental prospects provide information on ways advance
Язык: Английский
Процитировано
44
Advanced Functional Materials, Год журнала: 2024, Номер 34(28)
Опубликована: Фев. 7, 2024
Abstract The integration of real‐time monitoring and on‐demand treatment has substantial potential to accelerate wound healing processes. In this context, versatile bilayer microneedles (MNs) a triboelectric nanogenerator (TENG) are developed as theranostic platform for efficient management. This provides benefits including controlling infection, promoting cell migration proliferation, the capability biochemical sensing. MNs comprise solvable polyvinylpyrrolidone MN (pMN) affixed atop conductive stainless‐steel (sMN). robust sMN penetrates requisite skin depth, while pMN, infused with antibiotics, ensures sustained drug release upon dissolution in interstitial fluids. Concurrently, TENG generates electrical stimulation transmitted site through sMN, contributing accelerated closure. Furthermore, coated silver carbon nanotubes (CNT/Ag/sMN), functions transdermal electrochemical sensor assess state by detecting hydrogen peroxide uric acid. Notably, vivo animal studies have demonstrated that MN‐TENG device not only effectively inhibits bacterial growth expedites but also monitors biomarkers, thereby validating its utility improving infected recovery. Consequently, based strategy fosters advancements diagnostic therapeutic technologies within management related biomedical domains.
Язык: Английский
Процитировано
33
Materials Today Chemistry, Год журнала: 2024, Номер 41, С. 102300 - 102300
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
28
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Март 2, 2024
Abstract Real-time and continuous monitoring of nucleic acid biomarkers with wearable devices holds potential for personal health management, especially in the context pandemic surveillance or intensive care unit disease. However, achieving high sensitivity long-term stability remains challenging. Here, we report a tetrahedral nanostructure-based Natronobacterium gregoryi Argonaute (NgAgo) stable ultratrace unamplified acids (cell-free DNAs RNAs) vivo sepsis on device. This integrated wireless consists flexible circuit board, microneedle biosensor, stretchable epidermis patch enrichment capability. We comprehensively investigate recognition mechanism by NgAgo/guide DNA signal transformation within Debye distance. In experiments demonstrate suitability real-time cell-free RNA 0.3 fM up to 14 days. These results provide strategy highly sensitive molecular on-body detection acid.
Язык: Английский
Процитировано
26
Bioactive Materials, Год журнала: 2024, Номер 45, С. 301 - 321
Опубликована: Ноя. 27, 2024
Язык: Английский
Процитировано
24
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180
Опубликована: Авг. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Язык: Английский
Процитировано
20
Advanced Science, Год журнала: 2024, Номер 11(23)
Опубликована: Апрель 6, 2024
Abstract Bacterial skin infections are highly prevalent and pose a significant public health threat. Current strategies primarily focused on the inhibition of bacterial activation while disregarding excessive inflammation induced by dead bacteria remaining in body effect acidic microenvironment during therapy. In this study, novel dual‐functional MgB 2 microparticles integrated microneedle (MgB MN) patch is presented to kill eliminate for infection management. The not only can produce local alkaline promote proliferation migration fibroblasts keratinocytes, but also achieve >5 log inactivation. Besides, effectively mitigate bacteria‐induced through interaction with lipopolysaccharide (LPS). With incorporation these microparticles, resultant MN patches capture bacteria, thereby mitigating inflammation. Therefore, show good therapeutic efficacy managing animal infections, including abscesses wounds. These results indicate that reactive metal borides‐integrated hold great promise treatment clinical infections.
Язык: Английский
Процитировано
19
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 3, 2025
Sound signals not only serve as the primary communication medium but also find application in fields such medical diagnosis and fault detection. With public healthcare resources increasingly under pressure, challenges faced by disabled individuals on a daily basis, solutions that facilitate low-cost private hold considerable promise. Acoustic methods have been widely studied because of their lower technical complexity compared to other solutions, well high safety threshold human body acoustic energy. Furthermore, with recent development artificial intelligence technology applied speech recognition, recognition devices, systems capable assisting interacting scenes are constantly being updated. This review meticulously summarizes sensing mechanisms, materials, structural design, multidisciplinary applications wearable devices health human-computer interaction. Further, advantages disadvantages different approaches used flexible various examined. Finally, current roadmap for future research analyzed based existing progress achieve more comprehensive personalized healthcare.
Язык: Английский
Процитировано
4
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Фев. 6, 2025
Abstract The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints conventional methods by their superior safety and efficacy through precise targeting, while simultaneously enabling painless delivery. Currently, are increasingly used carriers delivery, with loading insoluble drugs to improve treatment efficiency or combining bioactive substances construction efficient system maximize effects substances. preparation diverse, them meet requirements most applications. emergence addressed shortcomings associated drugs, expanded applications substances, improved in clinical practice. This review summarizes current information on application a variety such psoriasis, vitiligo, alopecia, hypertrophic scarring, atopic dermatitis, melanoma, acne, infections. future opportunities diseases also discussed. Despite substantial progress vectors, issues low poor mechanical strength during remain main challenges. Therefore, implementation MNs-based therapies remains limited, highlighting key research.
Язык: Английский
Процитировано
3
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Abstract Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated platforms. Microneedles enhance access biomarkers via interstitial fluid, enabling real‐time monitoring physiological conditions, such as glucose hormone levels, thus facilitating continuous health tracking. The evolution design solid dissolvable forms broadens their utility mere complex sensing applications, including insulin for diabetes management, vaccination, gene therapy. paper delves into integration microneedles wearable technologies, highlighting role closed‐loop systems that combine dynamic, precise delivery. By addressing gaps literature regarding integrated treatment capabilities, this underscores pivotal personalizing medicine. It concludes visionary perspective on future trajectory technology, emphasizing potential revolutionize strategies through enhanced efficacy, safety, patient compliance.
Язык: Английский
Процитировано
2