Advanced Healthcare Materials,
Год журнала:
2022,
Номер
11(22)
Опубликована: Сен. 13, 2022
Abstract
Ulcerative
colitis
(UC)
is
a
prevalent
idiopathic
inflammatory
disease
which
causes
such
complications
as
intestinal
perforation,
obstruction,
and
bleeding,
thus
deleteriously
impacting
people's
normal
work
quality
of
life.
Hence,
accurate
diagnosis
UC
crucial
in
terms
planning
optimal
treatment
plan.
Herein,
pH/reactive
oxygen
species
(ROS)
dual‐responsive
nanosystem
(BM@EP)
developed
for
UC's
detection
therapy.
BM@EP
composed
chromophore‐drug
dyad
the
enteric
coating.
The
(BOD‐XT‐DHM)
synthesized
by
linking
chromophore
(BOD‐XT‐BOH)
flavonoid
drug
(dihydromyricetin
DHM)
through
boronate
ester
bond.
coating
includes
Eudragit
S100
poly(lactic‐
co
‐glycolic
acid)
(PLGA),
former
commonly
employed
pH‐dependent
polymer
excipient
so
to
attain
colon‐targeted
delivery,
latter
has
been
widely
used
an
controlled‐extended
release.
After
oral
administration,
delivers
into
colon
releases
molecules
being
triggered
alkaline
pH
t
colon,
thereafter
upon
stimulated
overexpressed
H
2
O
inflamed
bond
broken
down
correspondingly
DHM
released
therapy,
simultaneously
near‐infrared
second
window
(NIR‐II)
fluorescence
optoacoustic
imaging
recovery
evaluation.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(26), С. 10488 - 10495
Опубликована: Июнь 20, 2024
Hydrogen
peroxide
(H2O2)
overexpressed
in
mitochondria
has
been
regarded
as
a
key
biomarker
the
pathological
processes
of
various
diseases.
However,
there
is
currently
lack
suitable
mitochondria-targetable
near-infrared
(NIR)
probes
for
visualization
H2O2
multiple
diseases,
such
PM2.5
exposure-induced
lung
injury,
hepatic
ischemia-reperfusion
injury
(HIRI),
nonalcoholic
fatty
liver
(NAFL),
fibrosis
(HF),
and
malignant
tumor
tissues
containing
clinical
cancer
patient
samples.
Herein,
we
conceived
novel
NIR
fluorescent
probe
(HCy-H2O2)
by
introducing
pentafluorobenzenesulfonyl
sensing
unit
into
hemicyanine
platform.
HCy-H2O2
exhibits
good
sensitivity
selectivity
toward
H2O2,
accompanied
remarkable
"turn-on"
fluorescence
signal
at
720
nm.
Meanwhile,
stable
ability
permits
monitoring
up-generated
level
during
mitophagy.
Furthermore,
using
HCy-H2O2,
have
successfully
observed
an
overproduced
mitochondrial
ambient
HIRI,
NAFL,
HF
models
through
imaging.
Significantly,
achieved
both
tumor-bear
mice
well
surgical
specimens
patients,
making
promising
tool
diagnosis
imaging-guided
surgery.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
11(22)
Опубликована: Сен. 13, 2022
Abstract
Ulcerative
colitis
(UC)
is
a
prevalent
idiopathic
inflammatory
disease
which
causes
such
complications
as
intestinal
perforation,
obstruction,
and
bleeding,
thus
deleteriously
impacting
people's
normal
work
quality
of
life.
Hence,
accurate
diagnosis
UC
crucial
in
terms
planning
optimal
treatment
plan.
Herein,
pH/reactive
oxygen
species
(ROS)
dual‐responsive
nanosystem
(BM@EP)
developed
for
UC's
detection
therapy.
BM@EP
composed
chromophore‐drug
dyad
the
enteric
coating.
The
(BOD‐XT‐DHM)
synthesized
by
linking
chromophore
(BOD‐XT‐BOH)
flavonoid
drug
(dihydromyricetin
DHM)
through
boronate
ester
bond.
coating
includes
Eudragit
S100
poly(lactic‐
co
‐glycolic
acid)
(PLGA),
former
commonly
employed
pH‐dependent
polymer
excipient
so
to
attain
colon‐targeted
delivery,
latter
has
been
widely
used
an
controlled‐extended
release.
After
oral
administration,
delivers
into
colon
releases
molecules
being
triggered
alkaline
pH
t
colon,
thereafter
upon
stimulated
overexpressed
H
2
O
inflamed
bond
broken
down
correspondingly
DHM
released
therapy,
simultaneously
near‐infrared
second
window
(NIR‐II)
fluorescence
optoacoustic
imaging
recovery
evaluation.
