Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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3D and 4D Bioprinting Technologies: A Game Changer for the Biomedical Sector?

Annals of Biomedical Engineering, Год журнала: 2023, Номер 51(8), С. 1683 - 1712

Опубликована: Июнь 1, 2023

Язык: Английский

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Coordination Chemistry Reviews, Год журнала: 2024, Номер 514, С. 215907 - 215907

Опубликована: Май 12, 2024

Язык: Английский

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Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Advanced Functional Materials, Год журнала: 2024, Номер 34(36)

Опубликована: Март 29, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), emerged a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, remarkable chemical stability, undergone comprehensive investigation extensive exploration within realm of biological theranostics. This work aims to provide summary advancements development design strategies NIR‐II BODIPY fluorophores tailored advanced phototheranostics. Initially, elucidates several representative strategies, concluding electron‐programming strategy, extension conjugated backbone, J‐aggregation strategic establishment activatable fluorophores, which enhance skeletons. Subsequently, developments fluorescent BODIPY‐based nanoplatforms applications are intricately elaborated. In conclusion, this outlines future efforts directions refining meet evolving clinical demands. It is anticipated that contribution may feasible reference thereby advancing their potential practices.

Язык: Английский

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Renal-Clearable Probe with Water Solubility and Photostability for Biomarker-Activatable Detection of Acute Kidney Injuries via NIR-II Fluorescence and Optoacoustic Imaging

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(14), С. 17664 - 17674

Опубликована: Апрель 3, 2023

Acute kidney injuries (AKI) have serious short-term or long-term complications with high morbidity and mortality rate, thus posing great health threats. Developing high-performance NIR-II probes for noninvasive in situ detection of AKI via fluorescent optoacoustic dual-mode imaging is significance. Yet chromophores often feature long conjugation hydrophobicity, which prevent them from being renal clearable, limiting their applications the diseases. To fully exploit advantageous features heptamethine cyanine dye, while overcoming its relatively poor photostability, to strive design a probe imaging, herein, we developed PEG3-HC-PB, water soluble, biomarker activatable has good photostability. As probe, fluorescence (900-1200 nm) quenched due existence electron-pulling phenylboronic group (responsive element), it exhibits weak absorption peak at 830 nm. Meanwhile, presence overexpressed H2O2 region case AKI, converted phenylhydroxy group, enhances emission (600-900 eventually produces conspicuous signals imaging. This enables contrast-agent-induced ischemia/reperfusion-induced mice using real-time 3D-MSOT response H2O2. Hence, this can be used as practicable tool detecting AKI; additionally, strategy could provide insight into other large-conjugation multifarious biological applications.

Язык: Английский

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Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Theranostics, Год журнала: 2024, Номер 14(6), С. 2490 - 2525

Опубликована: Янв. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Язык: Английский

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Biomaterials for inflammatory bowel disease: treatment, diagnosis and organoids

Applied Materials Today, Год журнала: 2024, Номер 36, С. 102078 - 102078

Опубликована: Янв. 20, 2024

Язык: Английский

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Recent advances on emerging nanomaterials for diagnosis and treatment of inflammatory bowel disease

Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 149 - 179

Опубликована: Сен. 27, 2023

Язык: Английский

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Injectable‐Hydrogel‐Based Tissue Sealant for Hemostasis, Bacteria Inhibition, and Pro‐Angiogenesis in Organ Bleeding Wounds and Therapeutic Outcome Monitoring Via NIR‐II Optical Imaging

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(12)

Опубликована: Янв. 28, 2024

Abstract Sudden hemorrhage stemming from internal organ wounds poses a grave and potentially fatal risk if left untreated. Injectable‐hydrogel‐based tissue sealants featuring multiple actions, including fit‐to‐shape in situ gelation, rapid hemostasis, pro‐angiogenic, anti‐bacterial outcome tracking, are ideal for the management of trauma wounds. Herein, an injectable‐hydrogel sealant AN@CD‐PEG&TQ which consists four‐arm 4‐arm poly(ethylene glycol) (PEG‐SC) succinimidyl carbonate), AN@CD nanoprobe, two bioactive peptides (anti‐microbial peptide Tet213 pro‐angiogenic QK) is developed. Among them, nanoparticles form through host/guest complexation amino‐group‐containing β‐cyclodextrin adamantyl group, enabling biomarker (NO)‐activatable optoacoustic/NIR‐II: Near‐infrared second biological window fluorescent imaging. The ample ─NH2 groups on surface readily engage cross‐linking with ester located at ends PEG‐SC. This expedites gelation process without necessitating additional initiators or agents; thus, significantly enhancing both hydrogel's application convenience biocompatibility. Bioactive (Tet213 safeguard against possible bacterial infections, facilitate angiogenesis, eventually, improve healing. hydrogel‐based demonstrates superior therapeutic bioimaging performance various mouse models liver hemorrhage, gastric perforation, bacterial‐infected skin wound models, highlighting its potential as high‐performance bleeding management.

Язык: Английский

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Homo‐Dyad with Outer Hydration Layer Approach for Developing NIR‐II Chromophore of High Stability and Water‐Solubility as Injectable and Sprayable Optical Probe

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Апрель 8, 2024

Dyes with extended conjugate structures are the focus of extensive design and synthesis efforts, aiming to confer unique improved optical electronic properties. Such advancements render these dyes applicable across a wide spectrum uses, ranging from second-window near-infrared (NIR-II) bioimaging organic photovoltaics. Nevertheless, inherent benefits long conjugation often accompanied by persistent challenges like aggregation, fluorescence quenching, absorption blueshift, low stability poor water solubility. Herein, structural strategy termed "homo-dyad outer hydration layer" is introduced address problems, tailored for development imaging probes exhibiting absorption/emission wavelengths. This approach involves bringing two heptamethine cyanines together through flexible linker, forming homo-dyad structure, while strategically attaching four polyethylene glycol (PEG9) chains terminal heterocycles. imparts excellent solubility, biocompatibility, enhanced chemical, photo-, spectral dyes. Utilizing this strategy, biomarker-activatable probe (HD-FL-4PEG9-N) NIR-II fluorescent 3D multispectral optoacoustic tomography developed, its effectiveness in disease visualization. It can not only serve as an injectable acute kidney injury due high but also sprayable bacterial-infected wounds.

Язык: Английский

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