Biological Research For Nursing,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
Purpose:
Chronic
venous
leg
ulcers
(CVLUs)
comprise
the
majority
of
lower-extremity
wounds,
yet
their
pathophysiology
is
not
fully
understood.
While
research
has
shown
that
microRNAs
are
an
important
component
wound
inflammation,
few
have
explored
role
(miRNAs)
in
healing
CVLUs.
This
scoping
review
examines
miRNAs
CVLUs
and
association
with
healing.
Methods:
In
December
2023,
we
searched
MEDLINE/PubMed,
Embase,
Scopus,
CINAHL
for
studies
published
2013–2023
examining
CVLU
Results:
Six
met
inclusion
criteria.
MicroRNAs
were
extracted
from
various
specimens
including
serum,
skin
biopsy
samples,
adipose
tissue-derived
mesenchymal
cells
individuals
Overexpression
miR-221,
miR-222,
miR-92a,
miR-301a-3p
hindered
angiogenesis,
while
overexpression
miR-296,
miR-126,
miR-378,
miR-210
facilitated
angiogenesis.
miR-34a/c,
miR-301a-3p,
miR-450-5p,
miR-424-5p,
miR-516-5p,
miR-7704
increased
local
inflammatory
responses
inhibited
keratinocytes
proliferation,
impairing
healing,
miR-19a/b
miR-20
downregulated
keratinocytes'
response,
promoting
Downregulation
miR-205,
miR-96-5p,
miR-218-5p
enhanced
cellular
proliferation
promoted
miR-17–92
was
linked
impaired
Discussion:
play
a
regulating
responses,
cell
migration
chronic-wound
However,
limited
lack
standardized
approach
to
measurement
quantification.
Further
warranted
elucidate
mechanisms
underlying
microRNA
involvement
better
understand
future
development
targeted
therapies.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2494 - 2494
Опубликована: Март 11, 2025
Various
species
of
fungi
can
be
detected
in
the
environment
and
within
human
body,
many
which
may
become
pathogenic
under
specific
conditions,
leading
to
various
forms
fungal
infections.
Antimicrobial
peptides
(AMPs)
are
evolutionarily
ancient
components
immune
response
that
quickly
induced
infections
with
pathogens
almost
all
tissues.
There
is
a
wide
range
AMP
classes
humans,
exhibit
broad-spectrum
antimicrobial
function.
This
review
provides
comprehensive
overview
mechanisms
action
AMPs,
their
distribution
antifungal
activity
against
both
common
rare
clinical
pathogens.
It
also
discusses
current
research
status
promising
novel
strategies,
highlighting
challenges
must
overcome
development
these
therapies.
The
hope
peptides,
as
class
agents,
will
soon
progress
through
large-scale
trials
implemented
practice,
offering
new
treatment
options
for
patients
suffering
from
Abstract
Protein‐based
hydrogels
have
been
widely
used
in
the
biomedical
field
since
their
good
biocompatibility
and
adjustable
physical
properties,
which
are
also
similar
to
natural
extracellular
matrix.
However,
fragile
mechanical
properties
single
function
of
protein
limited
application.
Usually,
chemical
modification
proteins
combination
with
other
biological
materials
strategies
improve
performance
hydrogels.
This
review
first
focused
on
method
then
introduced
kinds
protein‐based
detail.
In
addition,
we
summarized
applications
drug
delivery,
wound
dressing,
tissue
engineering,
3D
printing,
biosensors.
Finally,
highlighted
challenges
future
prospects
hydrogels,
may
provide
a
reference
for
design
novel
multifunctional
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
6(21), С. 13341 - 13349
Опубликована: Окт. 29, 2024
Skin
is
the
initial
defense
against
infection
of
body
but
becomes
vulnerable
when
damaged.
Subsequent
bacterial
infections
can
cause
more
severe
ulcers.
Antibiotics
are
useful
for
infected
wound
healing
also
speed
up
evolution
antibiotic-resistant
bacteria.
Dressing
and
antibacterial
photodynamic
therapy
(PDT)
effective
methods
protecting
treating
wounds,
respectively.
Herein,
we
developed
a
spray
hydrogel
based
on
sodium
alginate
hydrogels,
loaded
with
methylene
blue
(MB)
closo-dodecaborate
cluster
(closo-B12H122–),
physical
protection
PDT.
Among
them,
MB
acted
as
photosensitizer,
which
produce
reactive
oxygen
species
(ROS)
through
PDT
process
to
implement
therapeutic
effect
toward
bacterial-infected
wounds.
closo-B12H122–
form
supramolecular
photosensitizer
(MB-B12),
reduce
dark
toxicity
without
significantly
affecting
its
effect.
Moreover,
introduction
upgrade
property
better
increase
loading
capacity
healing.
The
demonstrated
an
outstanding
ability
around
99%
Staphylococcus
aureus
95%
Escherichia
coli.
This
PDT-spray
system
be
favorable
option
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 11213 - 11233
Опубликована: Ноя. 1, 2024
Abstract:
Burn
wounds
pose
intricate
clinical
challenges
due
to
their
severity
and
high
risk
of
complications,
demanding
advanced
therapeutic
strategies
beyond
conventional
treatments.
This
review
discusses
the
application
nanoparticle-based
therapies
for
optimizing
burn
wound
healing.
We
explore
critical
phases
healing,
including
inflammation,
proliferation,
remodeling,
while
summarizing
key
that
influence
these
processes
optimize
Various
nanoparticles,
such
as
metal-based,
polymer-based,
extracellular
vesicles,
are
evaluated
distinctive
properties
mechanisms
action,
antimicrobial,
anti-inflammatory,
regenerative
effects.
Future
directions
highlighted,
focusing
on
personalized
integration
sophisticated
drug
delivery
systems,
emphasizing
transformative
potential
nanoparticles
in
enhancing
treatment.
Keywords:
nanomedicine,
burns,
wound,
regeneration,
therapy
