Multifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140326 - 140326
Опубликована: Янв. 1, 2025
Язык: Английский
One-step synthesis of an activatable hydrogen selenide donor with fluorescence-monitored release and its application in cells
Sensors and Actuators B Chemical,
Год журнала:
2025,
Номер
unknown, С. 137232 - 137232
Опубликована: Янв. 1, 2025
Язык: Английский
Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 29, 2025
Multifunctional
composite
wound
dressings
hold
significant
promise
for
diabetic
healing.
However,
the
detrimental
role
of
advanced
glycation
end-products
(AGEs)-reactive
oxygen
species
(ROS)
cycle
in
impeding
repair
remains
underexplored.
To
disrupt
this
pathological
cycle,
zeolitic
imidazolate
framework-8
(ZIF-8)
encapsulated
cerium
dioxide
(CeO2)
and
adsorbed
glucose
oxidase
(GOx)
nanozyme
particles
((ZIF-8@CeO2)@GOx,
zcg)
were
loaded
into
a
methacrylic
anhydride-modified
gelatin
(GelMA)
hydrogel
to
form
sprayable
dressing,
zcg/GelMA
(zcgG).
Physicochemical
characterization
revealed
that
GOx
catalyzes
oxidation,
triggering
ZIF-8
acid-mediated
decomposition
release
zinc
ions
CeO2
nanoparticles,
thereby
enabling
cascade
depletion,
antioxidant,
antiglycation
functions.
In
vitro
antimicrobial
cytotoxicity
experiments
optimized
zcg
concentration
GelMA.
Under
oxidative
hyperglycemic
culture
conditions,
we
validated
mechanism
blocking
AGEs-ROS
restoring
fibroblast
mitochondrial
membrane
potential,
subsequently
suppressing
cellular
senescence.
bacterial-infected
rat
skin
model,
zcgG
group
demonstrated
substantially
reduced
inflammatory
levels,
68%
decrease
AGEs,
1.9-fold
increase
collagen
deposition
compared
blank
controls.
Within
2
weeks,
achieved
complete
closure,
while
control
retained
28%
initial
area.
This
work
provides
preliminary
evidence
feasibility
using
nanozymes
break
promote
Язык: Английский
MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways
Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101435 - 101435
Опубликована: Дек. 28, 2024
Язык: Английский
Dual‐Cascade Responsive H2Se Delivery Nanogels Bearing Selenobenzamide as H2Se Donor for the Treatment of Multidrug Resistant Bacteria Infections
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Abstract
Hydrogen
selenide
(H
2
Se)
as
one
of
the
endogenous
gaseous
signaling
molecules
for
antibacterial
gas
therapy,
faces
limitations
such
high‐dose
toxicity
and
short
half‐life.
Herein,
a
polymeric
H
Se
delivery
nanogel
Se‐NG)
incorporated
with
aldehyde‐modified
selenobenzamide
(SeAs)
is
designed
multidrug
resistant
(MDR)
related
healthcare‐associated
infections
(HAIs)
treatment.
Se‐NG
facilitates
dual‐cascade
responsive
release
over
72
h,
effectively
addressing
safety
issues
caused
by
rapid
hydrolysis
traditional
inorganic
methods.
In
vitro
in
vivo
studies
demonstrate
that
nontoxic
doses
at
150
µg
mL
−1
not
only
eliminated
99%
MDR
bacteria
their
biofilm
within
8
h
while
reducing
levels
proinflammatory
cytokines
postinfection.
Additionally,
RNA
sequencing
results
reveal
released
induces
oxidative
stress
infection
site,
kills
biofilm‐embedded
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
leads
elimination
activating
dispersion
genes,
suggesting
potential
promising
strategy
therapy.
Язык: Английский