Dual‐Cascade Responsive H2Se Delivery Nanogels Bearing Selenobenzamide as H2Se Donor for the Treatment of Multidrug Resistant Bacteria Infections DOI Open Access
Gangfeng Li,

Zhuoya Feng,

Zishuo Hou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Hydrogen selenide (H 2 Se) as one of the endogenous gaseous signaling molecules for antibacterial gas therapy, faces limitations such high‐dose toxicity and short half‐life. Herein, a polymeric H Se delivery nanogel Se‐NG) incorporated with aldehyde‐modified selenobenzamide (SeAs) is designed multidrug resistant (MDR) related healthcare‐associated infections (HAIs) treatment. Se‐NG facilitates dual‐cascade responsive release over 72 h, effectively addressing safety issues caused by rapid hydrolysis traditional inorganic methods. In vitro in vivo studies demonstrate that nontoxic doses at 150 µg mL −1 not only eliminated 99% MDR bacteria their biofilm within 8 h while reducing levels proinflammatory cytokines postinfection. Additionally, RNA sequencing results reveal released induces oxidative stress infection site, kills biofilm‐embedded methicillin‐resistant Staphylococcus aureus (MRSA) leads elimination activating dispersion genes, suggesting potential promising strategy therapy.

Language: Английский

Multifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release DOI
Yan Wang, Chao Yang, Weigang Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140326 - 140326

Published: Jan. 1, 2025

Language: Английский

Citations

1
One-step synthesis of an activatable hydrogen selenide donor with fluorescence-monitored release and its application in cells DOI

Xiaodi Rong,

Caiyun Liu, Yao Wang

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137232 - 137232

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration DOI
Xinyi Zhang, Yuan Yang, Jianyu Su

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Multifunctional composite wound dressings hold significant promise for diabetic healing. However, the detrimental role of advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding repair remains underexplored. To disrupt this pathological cycle, zeolitic imidazolate framework-8 (ZIF-8) encapsulated cerium dioxide (CeO2) and adsorbed glucose oxidase (GOx) nanozyme particles ((ZIF-8@CeO2)@GOx, zcg) were loaded into a methacrylic anhydride-modified gelatin (GelMA) hydrogel to form sprayable dressing, zcg/GelMA (zcgG). Physicochemical characterization revealed that GOx catalyzes oxidation, triggering ZIF-8 acid-mediated decomposition release zinc ions CeO2 nanoparticles, thereby enabling cascade depletion, antioxidant, antiglycation functions. In vitro antimicrobial cytotoxicity experiments optimized zcg concentration GelMA. Under oxidative hyperglycemic culture conditions, we validated mechanism blocking AGEs-ROS restoring fibroblast mitochondrial membrane potential, subsequently suppressing cellular senescence. bacterial-infected rat skin model, zcgG group demonstrated substantially reduced inflammatory levels, 68% decrease AGEs, 1.9-fold increase collagen deposition compared blank controls. Within 2 weeks, achieved complete closure, while control retained 28% initial area. This work provides preliminary evidence feasibility using nanozymes break promote

Language: Английский

Citations

0
MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways DOI Creative Commons

Xueting Guo,

Wenqi Wang,

Liting Lin

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101435 - 101435

Published: Dec. 28, 2024

Language: Английский

Citations

0
Dual‐Cascade Responsive H2Se Delivery Nanogels Bearing Selenobenzamide as H2Se Donor for the Treatment of Multidrug Resistant Bacteria Infections DOI Open Access
Gangfeng Li,

Zhuoya Feng,

Zishuo Hou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Hydrogen selenide (H 2 Se) as one of the endogenous gaseous signaling molecules for antibacterial gas therapy, faces limitations such high‐dose toxicity and short half‐life. Herein, a polymeric H Se delivery nanogel Se‐NG) incorporated with aldehyde‐modified selenobenzamide (SeAs) is designed multidrug resistant (MDR) related healthcare‐associated infections (HAIs) treatment. Se‐NG facilitates dual‐cascade responsive release over 72 h, effectively addressing safety issues caused by rapid hydrolysis traditional inorganic methods. In vitro in vivo studies demonstrate that nontoxic doses at 150 µg mL −1 not only eliminated 99% MDR bacteria their biofilm within 8 h while reducing levels proinflammatory cytokines postinfection. Additionally, RNA sequencing results reveal released induces oxidative stress infection site, kills biofilm‐embedded methicillin‐resistant Staphylococcus aureus (MRSA) leads elimination activating dispersion genes, suggesting potential promising strategy therapy.

Language: Английский

Citations

0