Mitochondria-Targeting Type-I Photodynamic Therapy Based on Phenothiazine for Realizing Enhanced Immunogenic Cancer Cell Death via Mitochondrial Oxidative Stress
Zeyu Duan,
Lie Li,
Qiyu Zhan
и другие.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 125 - 139
Опубликована: Янв. 1, 2025
Photo-immunotherapy
faces
challenges
from
poor
immunogenicity
and
low
response
rate
due
to
hypoxic
microenvironment.
This
study
presents
Rh-PTZ,
a
small
organic
molecule
with
D-π-A
structure,
that
simultaneously
amplifies
mitochondria-targeted
type-I
PDT-dependent
immune
stimulation
for
the
treatment
of
cancer.
The
hydrophobic
Rh-PTZ
was
encapsulated
into
F127
prepare
nanoparticles
(Rh-PTZ
NPs).
ROS
generation
ability,
mitochondrial
targeting
capacity,
ICD
triggering
effect
mediated
by
NPs
under
LED
light
irradiation
were
investigated.
Based
on
4T1
subcutaneous
tumor
model,
in
vivo
biological
safety
assessment,
NIR
fluorescent
imaging,
efficacy
PDT
assessed.
could
efficiently
accumulate
site
induce
O2
•-
•OH
burst
situ
irradiation,
thereby
causing
severe
dysfunction.
can
amplify
stress-caused
immunogenic
cell
death
(ICD)
stimulate
response,
promote
maturation
sufficient
dendritic
cells
(DCs),
enhance
infiltration
cells,
alleviate
immunosuppressive
mitochondria-targeting
holds
promise
photo-immunotherapy
hypoxia
overcoming
limitations
traditional
immunotherapy.
Язык: Английский
Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy
Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
As
two
main
phototherapy
means,
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
different
photon‐transition
avenues
decided
by
the
aggregation
state
of
photosensitizers
(PSs),
thus
PDT
or
PTT
efficiency
can
be
regulated
regulating
PSs
aggregation.
A
co‐assembly
formulation
consisting
IR780
iodide
pentafluorophenyl
trifluoroacetate
is
constructed
through
intermolecular
interactions,
followed
coating
with
hyaluronic
acid.
Initially,
uniform
distribution
favors
more
reactive
oxygen
species
birth
to
implement
when
entering
cells
since
its
avenue
sequential
process
intersystem
crossing
transfer–collision
energy
transfer
predominant.
After
hyaluronidase
laser
irradiation‐induced
structural
collapse
co‐assembly,
free
aggregates
due
hydrophobic
interactions
even
though
they
are
excreted
out
cells,
then,
these
produce
heat
nonradiative
relaxation
execute
PTT.
Such
a
spatiotemporal
PDT–PTT
encourages
antitumor
immune
responses
mitigates
immunosuppression,
accomplishing
photoimmunotherapy
against
breast
cancer
progression.
Through
such
tumor
microenvironment‐adaptable
laser‐duration‐decided
alteration,
switching
insights
provided
into
single
PSs‐mediated
photoimmunotherapy.
Язык: Английский
Nanomaterials in gastric cancer: pioneering precision medicine for diagnosis, therapy, and prevention
Medical Oncology,
Год журнала:
2025,
Номер
42(4)
Опубликована: Март 6, 2025
Язык: Английский
US/PA/MR multimodal imaging-guided multifunctional genetically engineered bio-targeted synergistic agent for tumor therapy
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 10, 2024
Focused
ultrasound
ablation
surgery
(FUAS)
is
a
minimally
invasive
treatment
option
that
has
been
utilized
in
various
tumors.
However,
its
clinical
advancement
hindered
by
issues
such
as
low
safety
and
efficiency,
single
image
guidance
mode,
postoperative
tumor
residue.
To
address
these
limitations,
this
study
aimed
to
develop
novel
multi-functional
gas-producing
engineering
bacteria
biological
targeting
cooperative
system.
Pulse-focused
(PFUS)
could
adjust
the
ratio
of
thermal
effect
non-thermal
adjusting
duty
cycle,
improve
effectiveness
treatment.The
genetic
modification
Escherichia
coli
(E.coli)
involved
insertion
an
acoustic
reporter
gene
encode
gas
vesicles
(GVs),
resulting
E.coli
(GVs-E.coli)
capable
anoxia.
GVs-E.coli
colonized
proliferated
within
while
GVs
facilitated
imaging
PFUS.
Additionally,
multifunctional
cationic
polyethyleneimine
(PEI)-poly
(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(PEI-PLGA/EPI/PFH@Fe
Язык: Английский