Fabrication of Hyaluronic Acid‐Targeted Supramolecular Delivery Platform With pH and ROS‐Responsive Drug Release DOI Open Access

Kaixuan Jiang,

Wenhui Wu, Meiran Xie

и другие.

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

A supramolecular drug delivery system is fabricated here based on the assembly of β-cyclodextrin-modified hyaluronic acid (HACD) and ferrocene (Fc) with pH-sensitive polyhistidine (PHIS). The demonstrates efficient encapsulation hydrophobic anticancer drugs high stable loading capacity. drug-loaded nanoparticles utilize HACD as hydrophilic corona, enabling active tumor targeting through CD44 receptor-mediated endocytosis exhibiting dual stimuli-responsive release properties (ROS pH). In microenvironment characterized by elevated ROS levels acidic pH, undergo structural disassembly, switching from controlled to rapid liberation. Blank exhibit excellent biocompatibility, while formulations demonstrate selective cytotoxicity significantly reduced toxicity toward normal cells HFF-1 enhanced therapeutic efficacy against HeLa cancer cells. This nanoplatform improves aqueous solubility biocompatibility drugs, achieving intelligent double-modal stimulus-responsive release.

Язык: Английский

Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy DOI
Shuo Zhang, Xinyu Zhao, Wei Zhang

и другие.

Bioactive Materials, Год журнала: 2025, Номер 49, С. 63 - 84

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

1
Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy DOI
Yonghang Liu, Xiaoxue Yang, Kefan Wu

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by structure function skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed methyl acrylate (MA) (3-acrylamidophenyl)boronic acid (AAPBA) network co-loaded with antioxidant quercetin (Q) antibiotic levofloxacin (L) for efficient diabetic wound therapy. The MA segments undergo phase separation to form dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, high content. Meanwhile, AAPBA generate glucose-labile "sweat pores" via borate ester bonds polyphenol Q. Upon encountering hyperglycemic microenvironment, dilated due cleavage exposure diffusion channel, facilitating release accelerated healing. In infected rats, QL@MAB achieves rapid debridement re-epithelization while promoting angiogenesis, hair follicle regeneration, extracellular matrix remodeling. Taken together, this study not only represents multipronged dressing effective interventions but also contributes rational smart hydrogels tailored biomedical applications.

Язык: Английский

Процитировано

1
Ultrasound-induced piezoionic hydrogels with antibacterial and antioxidant properties for promoting infected diabetic wound healing DOI

Chunhua Huang,

Xingxing Shi,

Binying Peng

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A new class of ultrasound-induced piezoionic hydrogels with antibacterial and antioxidant properties are developed to accelerate infected diabetic wound healing.

Язык: Английский

Процитировано

0
Fabrication of Hyaluronic Acid‐Targeted Supramolecular Delivery Platform With pH and ROS‐Responsive Drug Release DOI Open Access

Kaixuan Jiang,

Wenhui Wu, Meiran Xie

и другие.

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

A supramolecular drug delivery system is fabricated here based on the assembly of β-cyclodextrin-modified hyaluronic acid (HACD) and ferrocene (Fc) with pH-sensitive polyhistidine (PHIS). The demonstrates efficient encapsulation hydrophobic anticancer drugs high stable loading capacity. drug-loaded nanoparticles utilize HACD as hydrophilic corona, enabling active tumor targeting through CD44 receptor-mediated endocytosis exhibiting dual stimuli-responsive release properties (ROS pH). In microenvironment characterized by elevated ROS levels acidic pH, undergo structural disassembly, switching from controlled to rapid liberation. Blank exhibit excellent biocompatibility, while formulations demonstrate selective cytotoxicity significantly reduced toxicity toward normal cells HFF-1 enhanced therapeutic efficacy against HeLa cancer cells. This nanoplatform improves aqueous solubility biocompatibility drugs, achieving intelligent double-modal stimulus-responsive release.

Язык: Английский

Процитировано

0