Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity DOI
Xu Guo, Xin Liang, Jiale Liu

и другие.

Journal of Medicinal Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

The emerged apoptosis/ferroptosis synergistic platinum-based therapy has attracted a lot of attention but is far from clinic use due to high systemic toxicity. Herein, series novel precise carrier-free self-assembled platinum(IV) nanoparticles with lipid regulation effect named FSPNPs (5NPs–8NPs) were constructed via connecting fenofibrate acid (FA) cisplatin or oxaliplatin-derived platinum(IV)-intermediates disulfide bonds. can be stimulated by high-glutathione/ascorbic and acidity environment produce an "explosion-like" cascade release process. Cell-activity showed precision FSPNPs, which accumulated more in tumor cells inhibited cell proliferation. Especially, 5NPs have higher selectivity than cisplatin. downregulated glutathione/glutathione peroxidase 4, increased reactive oxygen species/lipid peroxidation/malondialdehyde, induced DNA damage/S-phase arrest, regulated p53/Bcl-2/Bax trigger the hybrid pathway. released FA derivates docked into peroxisome proliferator-activated receptor α activating cholesterol metabolism destroy membrane integrity. also good biocompatibility superior antitumor activity no observable tissue damage.

Язык: Английский

Cell death pathways: molecular mechanisms and therapeutic targets for cancer DOI Creative Commons
Shaohui Wang, Sa Guo, Jing Guo

и другие.

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Сен. 1, 2024

Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.

Язык: Английский

Процитировано

12
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529

Опубликована: Июнь 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Язык: Английский

Процитировано

8
Self-assembled hyaluronic acid nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis DOI
Jianbin Shi, Wenjing Ma,

Jia Deng

и другие.

Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122489 - 122489

Опубликована: Июль 14, 2024

Язык: Английский

Процитировано

4
Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment DOI

Ruiping Huang,

Yu Jiang, Baoyue Zhang

и другие.

Biomaterials, Год журнала: 2024, Номер 315, С. 122954 - 122954

Опубликована: Ноя. 7, 2024

Язык: Английский

Процитировано

4
Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006 DOI
Yinyin Wang,

Yu-Song Wang,

Jun‐Jiang Li

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 158, С. 108342 - 108342

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Knowledge Mapping of Ferroptosis in Sarcoma: A Bibliometric and Bioinformatics Analysis (2012–2023) DOI
Zhen Cao,

Cheng-Long Qu,

Fan Yang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Abstract Background: Sarcoma, a rare and heterogeneous group of malignant tumors originating from mesenchymal tissues, presents significant challenge in terms diagnosis treatment. Ferroptosis, newly emerging field research, is new type iron-dependent cell death, which different apoptosis autophagy. Despite the clinical importance understanding relationship between sarcoma ferroptosis, limited studies have investigated this topic. Therefore, there need to conduct comprehensive bibliometric bioinformaticsanalysis provide overview current research domain. Methods: In study, we employed three main methods, namely CiteSpace, VOSviewer, R package "bibliometrix" analyze relevant literature. Publications related ferroptosis Science Citation Index Expanded Web Core Collection (WoSCC) database 2012 2023 were included. studio some public databases used for bioinformatics. Results: The analysis revealed that on has experienced steady increase over years, with diverse range topics collaborations established among researchers worldwide. The key findings include identification influential authors institutions, prominent clusters, trends. bioinformatics results confirmed significance ferroptosis-related gene ACSF2 sarcomas. Notably, scarcity focusing been observed, highlighting potential further exploration area. Conclusion: integration bibliometrics provides valuable insights into landscape ferroptosis. Future will continue focus its mechanisms sarcomas including immune microenvironment, while also exploring applications. We identified may directions

Язык: Английский

Процитировано

0
Exploring the interplay between iron metabolism imbalance and esophageal cancer DOI
Lu Qi, Zhongwen Li

ONCOLOGIE, Год журнала: 2024, Номер 26(4), С. 509 - 523

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

1
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity DOI
Xu Guo, Xin Liang, Jiale Liu

и другие.

Journal of Medicinal Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

The emerged apoptosis/ferroptosis synergistic platinum-based therapy has attracted a lot of attention but is far from clinic use due to high systemic toxicity. Herein, series novel precise carrier-free self-assembled platinum(IV) nanoparticles with lipid regulation effect named FSPNPs (5NPs–8NPs) were constructed via connecting fenofibrate acid (FA) cisplatin or oxaliplatin-derived platinum(IV)-intermediates disulfide bonds. can be stimulated by high-glutathione/ascorbic and acidity environment produce an "explosion-like" cascade release process. Cell-activity showed precision FSPNPs, which accumulated more in tumor cells inhibited cell proliferation. Especially, 5NPs have higher selectivity than cisplatin. downregulated glutathione/glutathione peroxidase 4, increased reactive oxygen species/lipid peroxidation/malondialdehyde, induced DNA damage/S-phase arrest, regulated p53/Bcl-2/Bax trigger the hybrid pathway. released FA derivates docked into peroxisome proliferator-activated receptor α activating cholesterol metabolism destroy membrane integrity. also good biocompatibility superior antitumor activity no observable tissue damage.

Язык: Английский

Процитировано

0