International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(23), С. 16870 - 16870
Опубликована: Ноя. 28, 2023
Major
depressive
disorder
(MDD)
has
a
high
prevalence
and
is
major
contributor
to
the
global
burden
of
disease.
This
psychiatric
results
from
complex
interaction
between
environmental
genetic
factors.
In
recent
years,
role
gut
microbiota
in
brain
health
received
particular
attention,
compelling
evidence
shown
that
patients
suffering
depression
have
dysbiosis.
Several
studies
reported
dysbiosis-induced
inflammation
may
cause
and/or
contribute
development
through
dysregulation
gut-brain
axis.
Indeed,
as
consequence
dysbiosis,
neuroinflammatory
alterations
caused
by
microglial
activation
together
with
impairments
neuroplasticity
symptoms.
The
modulation
been
recognized
potential
therapeutic
strategy
for
management
MMD.
this
regard,
physical
exercise
positively
change
composition
diversity,
can
underlie,
at
least
part,
its
antidepressant
effects.
Given
this,
present
review
will
explore
relationship
exercise,
depression,
an
emphasis
on
non-invasive
modulating
and,
regulating
axis
alleviating
MDD-related
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
156, С. 113848 - 113848
Опубликована: Окт. 13, 2022
Parkinson's
disease
(PD)
is
a
familiar
neurodegenerative
disease,
accompanied
by
motor
retardation,
static
tremor,
memory
decline
and
dementia.
Heredity,
environment,
age
oxidative
stress
have
been
suggested
as
key
factors
in
the
instigation
of
PD.
The
Keap1-Nrf2-ARE
signaling
one
most
significant
anti-
(OS)
pathways.
Keap1
negative
regulator
Nrf2.
pathway
can
induce
cell
oxidation
resistance
reduce
nerve
injury
to
treat
diseases.
Ellagic
acid
(EA)
inhibit
accumulate
Nrf2
nucleus,
act
on
ARE
produce
target
proteins,
which
turn
may
alleviate
impact
OS
neuronal
cells
This
review
analyzes
structure
physiological
role
EA,
along
with
structure,
composition
functions
pathway.
We
further
expound
mechanism
ellagic
its
activation
pathway,
well
relationship
between
EA
impairing
TLR4/Myd88/NF-κB
has
potentiality
improving
PD
activating
scavenging
free
radicals.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(23), С. 16870 - 16870
Опубликована: Ноя. 28, 2023
Major
depressive
disorder
(MDD)
has
a
high
prevalence
and
is
major
contributor
to
the
global
burden
of
disease.
This
psychiatric
results
from
complex
interaction
between
environmental
genetic
factors.
In
recent
years,
role
gut
microbiota
in
brain
health
received
particular
attention,
compelling
evidence
shown
that
patients
suffering
depression
have
dysbiosis.
Several
studies
reported
dysbiosis-induced
inflammation
may
cause
and/or
contribute
development
through
dysregulation
gut-brain
axis.
Indeed,
as
consequence
dysbiosis,
neuroinflammatory
alterations
caused
by
microglial
activation
together
with
impairments
neuroplasticity
symptoms.
The
modulation
been
recognized
potential
therapeutic
strategy
for
management
MMD.
this
regard,
physical
exercise
positively
change
composition
diversity,
can
underlie,
at
least
part,
its
antidepressant
effects.
Given
this,
present
review
will
explore
relationship
exercise,
depression,
an
emphasis
on
non-invasive
modulating
and,
regulating
axis
alleviating
MDD-related
