Candida and Long Covid DOI Creative Commons
Patrick Chambers

Опубликована: Июнь 6, 2024

The pandemic has supercharged growing awareness of the gut microbiome as a critical determinant human health. Long haulers share microbiomes similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia, all frequently associated with Candida overgrowth (CO). unique relationship indoleamine dioxygenase (IDO) altered tryptophan metabolism (ATM), mediated by IFN-γ. Zonulin, circulating protein that increases intestinal endothelial permeability, emerged central player. This can be activated proteases secreted mast cells, enabling myriad autoimmune other chronic diseases. Many these are long Covid (LC). hyphal walls express proteins analogous gliadin/gluten, e.g., celiac disease (CeD), mannans, Crohn’s (CrD), may trigger antigliadin possibly anti-GPCR auto-antibodies linked their lectin binding domain respectively. These latter include GPCR LC POTS. Both autoantibody producing pathways activate zonulin. IFN-γ, marker for LC, not only IDO but also synthesize mannan immune epitopes on its hyphae reveal remarkable spatial phylogenetic diversity. spike S SARS CoV2 attach both ACE2 receptor (required absorption) Toll-like receptor4 (TLR4) bearing cells enterocytes. Spike is persistent most and, ligand TLR4, NLRP3 inflammasome, candidalysin. inflammasome directly connected dementia, cancer, autoimmunity obesity. A hypothetical pathophysiologic model proposed implicating pre-existing CO, aggravated Covid-19, genesis disease, many diseases, aging. accomplish this or through IFN-γ induced upregulation even IDO.

Язык: Английский

Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets DOI Creative Commons
Bruna R. Kouba, Laura A. Borba, Pedro Borges de Souza

и другие.

Cells, Год журнала: 2024, Номер 13(5), С. 423 - 423

Опубликована: Фев. 28, 2024

The involvement of central and peripheral inflammation in the pathogenesis prognosis major depressive disorder (MDD) has been demonstrated. increase pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, TNF-α) individuals with depression may elicit neuroinflammatory processes inflammation, mechanisms that, turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation dysbiosis induce alterations tryptophan metabolism, culminating decreased serotonin synthesis, impairments neuroplasticity-related mechanisms, glutamate-mediated excitotoxicity. This review aims highlight inflammatory (neuroinflammation, dysbiosis) involved pathophysiology MDD explore novel anti-inflammatory therapeutic approaches for this psychiatric disturbance. Several lines evidence have indicated that addition antidepressants, physical exercise, probiotics, nutraceuticals (agmatine, ascorbic acid, vitamin D) possess effects their antidepressant properties. Further studies are necessary benefits these alternative therapies MDD.

Язык: Английский

Процитировано

65
Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (Long Covid), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play DOI Open Access
Patrick Chambers

Qeios, Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role these on invading Candida hyphae explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens (epitopes), suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.

Язык: Английский

Процитировано

5
Associations between specific dietary patterns, gut microbiome composition, and incident subthreshold depression in Chinese young adults DOI Creative Commons

Xiumin Jiang,

Xiaotong Wang, Meng Zhang

и другие.

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

The interplay between influential factors and the incidence of subthreshold depression (SD) in young adults remains poorly understood. This study sought to understand dietary habits, gut microbiota composition, etc. among individuals with SD investigate their association occurrence. Employing a cross-sectional approach, 178 SD, aged 18–32 years, were matched 114 healthy counterparts. status was evaluated using Zung Self-rating Depression Scale (SDS), Anxiety (SAS), Beck Inventory 2nd version (BDI-II), 17-item Hamilton Rating Scales (HAMD-17), Pittsburgh Sleep Quality Index (PSQI). Metagenomic sequencing utilized identify fecal microbial profiles. Dietary patterns discerned via factor analysis 25-item food frequency questionnaire (FFQ). Logistic regression mediation performed explore potential links microbiota, patterns, incident SD. Data on habits available for 292 participants (mean [SD] age, 22.1 [2.9] years; 216 [73.9 %] female). revealed that Ⅰ (odds ratio [OR], 0.34; 95 % CI, 0.15–0.75) IV (OR, 0.39; 0.17–0.86 OR, 0.18–0.84) associated reduced risk Distinct profiles observed marked by increased diversity taxonomic alterations. Moreover, suggested Veillonella atypica as mediator linking SDS or BDI-II scores pattern rich bean products, coarse grains, nuts, fruits, mushrooms, potatoes (β = 0.25, CI: 0.02–0.78 β 0.18, 0.01–0.54). Our findings highlight complex developing adults, underscoring interventions microbiome modulation mental health promotion.

Язык: Английский

Процитировано

5
Exploring the Potential of Probiotics and Prebiotics in Major Depression: From Molecular Function to Clinical Therapy DOI
Xin Yuan,

Jianbo Chai,

Wenqiang Xu

и другие.

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер 16(6), С. 2181 - 2217

Опубликована: Июль 30, 2024

Язык: Английский

Процитировано

4
Post-marketing safety surveillance of vortioxetine hydrobromide: a pharmacovigilance study leveraging FAERS database DOI Creative Commons
Ying Zhang,

Shengzhu Sun,

Yaogui Ning

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Фев. 24, 2025

Vortioxetine hydrobromide is a widely prescribed medication for the treatment of major depressive disorder (MDD), primarily exerting its antidepressant effects by inhibiting reuptake serotonin (5-HT).The objective this study was to investigate adverse events (AEs) associated with vortioxetine through data mining in FDA Adverse Event Reporting System (FAERS) enhance clinical safety. We collected FAERS from Q3 2013 Q1 2024 cleansing. Disproportionality analysis employed quantify relevant AEs vortioxetine. Reported Ratio Ratios (ROR) utilized identifying risk signals within data. Organ Classes (SOCs) and selected Preferred Terms (PTs) Medical Dictionary Regulatory Activities (MedDRA version 26.1). A total 11,298 cases were reported as "primary suspected (PS)" hydrobromide. Notably, at systemic organ level (SOC) level, involved 27 organoid classes (SOCs).We identified 150 significantly disproportionate that met all four algorithms. This Our findings offer valuable insights optimizing use reducing potential side effects, serving reference rational safe application.

Язык: Английский

Процитировано

0
Non-aversive handling in laboratory animals and its effects on depressive-like and anxiety-related behaviors: a scoping review DOI
Louise Castro de Jesus, Ana Lúcia S. Rodrigues

Physiology & Behavior, Год журнала: 2025, Номер unknown, С. 114883 - 114883

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The role of microbiome in gut-brain-axis dysbiosis causing depression: From mechanisms to treatment DOI

Junqiao Mi,

Julia Morys, Marta Nowacka-Chmielewska

и другие.

International review of neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Candida and Long Covid: Mannan Not from Heaven DOI Open Access
Patrick Chambers

Qeios, Год журнала: 2024, Номер unknown

Опубликована: Июнь 24, 2024

The pandemic has supercharged growing awareness of the gut microbiome as a critical determinant human health. “Long haulers” share microbiomes similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia, all frequently associated with Candida overgrowth (CO). can synthesize its own IDO, altering tryptophan metabolism (ATM). Zonulin, circulating protein that increases intestinal endothelial permeability, emerged central player. hyphal walls express proteins analogous gliadin/gluten, e.g., celiac disease (CeD), mannans, Crohn’s (CrD), may trigger antigliadin anti-Gq coupled GPCR auto-antibodies linked their lectin binding domain respectively. Hyphal mannan induce AT1Rs, α1-ARs, mAChRs, β2-ARs, prominent LC, regulate T cell receptors (TCRs) regulatory B function, compromised not only LC (vitiligo, psoriasis, alopecia) but also SLE, RA, many other autoimmune diseases. All are Gq GPCRs. spike S on SARS CoV2 attach both ACE2 receptor (required for absorption) Toll-like receptor4 (TLR4) bearing cells enterocytes. Spike is persistent most and, ligand TLR4, activate zonulin. NLRP3 inflammasome, candidalysin. This inflammasome directly connected dementia, cancer, autoimmunity obesity. Candidalysin causes hypercitrullination, instrumental creating ACPAs (anti-citrullinated peptide antibodies) MCAS (mast activation syndrome), HSD (hypermobility spectrum disorder), APS (antiphospholipid syndrome). A hypothetical pathophysiologic model proposed implicating pre-existing CO, aggravated by Covid-19, genesis disease, chronic diseases, aging.

Язык: Английский

Процитировано

2
Staunch the Age Related Decline into Depression, Dementia, Diabetes, Obesity, Cancer, Long Covid, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play DOI Open Access
Patrick Chambers

Опубликована: Янв. 30, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, triggers altered tryptophan metabolism release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β, that also characterize chronic inflammation, oxidative stress, multitude diseases, all exhibiting HRV. Gut dysbiosis upregulates IFN-γ with it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to kynurenine, increasing kynurenine ratio (KTR). An elevated KTR is positively linked neurodegenerative autoimmune negatively Elevated activity not only enzymatic but an intracellular signal transducer potentiated by TGF-β. This cytokine primary determinant TME. The triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, suppress inflammatory triad, balance TGF-β, depress KTR, elevate HRV, extend lifespan.

Язык: Английский

Процитировано

1
Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (POTS), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play DOI Open Access
Patrick Chambers

Опубликована: Фев. 7, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, alters tryptophan metabolism with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases, all exhibiting HRV. Gut dysbiosis upregulates IFN-γ it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to that induced kynurenine, increasing kynurenine ratio (KTR). An elevated KTR is positively linked neurodegenerative autoimmune negatively Elevated activity not only enzymatic but an intracellular signal transducer potentiated by TGF-β. This cytokine primary determinant TME. Also proposed gut-lung concept consequent degradation ACE2 (richest lungs gut). Leaky autoantibodies related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. Aldosterone paroxysmal orthostatic tachycardia syndrome (POTS) paradoxes are highlighted context GPCR dysbiosis, role Candida explored. The triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry antigens, suppress inflammatory triad, balance TGF-β, depress KTR, elevate HRV, extend lifespan its quality.

Язык: Английский

Процитировано

1