Evidences and perspectives of the use of probiotics, prebiotics, synbiotics, and postbiotics as adjuvants for prevention and treatment of COVID-19: A bibliometric analysis and systematic review

Trends in Food Science & Technology, Год журнала: 2022, Номер 120, С. 174 - 192

Опубликована: Янв. 2, 2022

Язык: Английский

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Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Март 8, 2023

The gut microbiota plays a crucial role in human health and disease. Gut dysbiosis is known to be associated with increased susceptibility respiratory diseases modifications the immune response homeostasis of lungs (the so-called gut-lung axis). Furthermore, recent studies have highlighted possible neurological disturbances, introducing notion "gut-brain axis." During last 2 years, several described presence during coronavirus disease 2019 (COVID-19) its relationship severity, SARS-CoV-2 gastrointestinal replication, inflammation. Moreover, persistence after resolution may linked long-COVID syndrome particularly manifestations. We reviewed evidence on association between COVID-19, investigating epidemiologic confounding factors like age, location, sex, sample size, severity disease, comorbidities, therapy, vaccination status airway microbial selected both COVID-19 long-COVID. we analyzed strictly related microbiota, specifically diet investigation previous use antibiotics/probiotics, methodology used study (α- β-diversity parameters relative abundance tools). Of note, only few focused longitudinal analyses, especially for long-term observation Lastly, there lack knowledge regarding transplantation other therapeutic approaches their impact progression severity. Preliminary data seem suggest that might play symptoms. Indeed, development interpretation these could important implications future preventive strategies.

Язык: Английский

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Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

Biomedicines, Год журнала: 2021, Номер 9(10), С. 1340 - 1340

Опубликована: Сен. 28, 2021

Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among numerous benefits, their antioxidant properties attracting more attention. Multiple in vivo vitro studies have demonstrated that lactobacilli bifidobacteria, along with cellular components, possess excellent capacity, which provides a certain degree protection to the body against diseases associated oxidative stress. Recently, begun be considered as new source natural antioxidants. This review summarizes current state research on various bifidobacteria. Special emphasis is given mechanisms activity these bacteria microbiota, involve bacterial cell components metabolites. also dedicated genes involved strains indicators potential Identification biomarkers microbiota great importance both for creating diagnostic systems assessing stress choosing strategies aimed at restoring normal functioning and, through it, health. In this review, practical application probiotic proven prevent considered.

Язык: Английский

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Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features

Communications Biology, Год журнала: 2021, Номер 4(1)

Опубликована: Апрель 13, 2021

The relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the mycobiota of 67 patients, 35 H1N1-infected patients 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing analysed their associations with clinical features bacterial microbiota. Compared to HCs, fungal burden was higher. Fungal dysbiosis in both mainly characterized by depletion fungi such as Aspergillus Penicillium, but several fungi, including Candida glabrata, were enriched patients. profiles mild severe symptoms similar. Hospitalization had no apparent additional effects. In Mucoromycota positively correlated Fusicatenibacter, niger diarrhoea, Penicillium citrinum negatively C-reactive protein (CRP). penicilloides Lachnospiraceae members, CRP, procalcitonin. Therefore, occurs does improve until are discharged longer require medical attention.

Язык: Английский

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Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation

Foods, Год журнала: 2021, Номер 10(6), С. 1297 - 1297

Опубликована: Июнь 4, 2021

Growing interest in the development of innovative functional products as ideal carriers for synbiotics, e.g., nutrient bars, yogurt, chocolate, juice, ice cream, and cheese, to ensure daily intake probiotics prebiotics, which are needed maintain a healthy gut microbiota overall well-being, is undeniable inevitable. This review focuses on modern approaches that currently being developed modulate microbiota, with an emphasis health benefits mediated by co-encapsulated synbiotics immobilized probiotics. The impact processing, storage, simulated gastrointestinal conditions viability bioactivity together prebiotics such omega-3 polyunsaturated fatty acids, phytochemicals, dietary fibers using various delivery systems considered. Despite proven biological properties research this area needs be focused proper selection probiotic strains, their prebiotic counterparts, avoid suppression synergistic or complementary effect human health. Future directions should lead food containing stable tailored different age groups specifically designed fulfill adjuvant therapy.

Язык: Английский

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Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Март 4, 2022

The Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory 2 (SARS-CoV-2) emerged in late December 2019. Considering the important role of gut microbiota maturation, regulation, and induction immune system subsequent inflammatory processes, it seems that evaluating composition COVID-19 patients compared with healthy individuals may have potential value as a diagnostic and/or prognostic biomarker for disease. Also, therapeutic interventions affecting microbial flora open new horizons treatment accelerating their recovery.

Язык: Английский

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The role of probiotics in coronavirus disease-19 infection in Wuhan: A retrospective study of 311 severe patients

International Immunopharmacology, Год журнала: 2021, Номер 95, С. 107531 - 107531

Опубликована: Март 7, 2021

Язык: Английский

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The role of the microbiota in the management of intensive care patients

Annals of Intensive Care, Год журнала: 2022, Номер 12(1)

Опубликована: Янв. 5, 2022

Abstract The composition of the gut microbiota is highly dynamic and changes according to various conditions. mainly includes difficult-to-cultivate anaerobic bacteria, hence knowledge about its has significantly arisen from culture-independent methods based on next-generation sequencing (NGS) such as 16S profiling shotgun metagenomics. patients hospitalized in intensive care units (ICU) undergoes many alterations because critical illness, antibiotics, other ICU-specific medications. It then characterized by lower richness diversity, dominated opportunistic pathogens Clostridioides difficile multidrug-resistant bacteria. These are associated with an increased risk infectious complications or death. Specifically, at time writing, it appears possible identify distinct patterns severity infectivity COVID-19 patients, paving way for potential use dysbiosis markers predict patient outcomes. Correcting disturbances avoid their consequences now possible. Fecal transplantation recommended recurrent C. infections microbiota-protecting treatments antibiotic inactivators currently being developed. growing interest microbiota-associated therapies suggests that control could be a key factor management critically ill patients. present narrative review aims provide synthetic overview microbiota, healthy individuals After introduction different techniques used studying we determinants involved alteration ICU latter’s consequences. Last, assess means prevent correct alteration.

Язык: Английский

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Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Archives of Microbiology, Год журнала: 2023, Номер 205(6)

Опубликована: Май 30, 2023

Язык: Английский

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Gut Microbiome Disruption Following SARS-CoV-2: A Review

Microorganisms, Год журнала: 2024, Номер 12(1), С. 131 - 131

Опубликована: Янв. 9, 2024

COVID-19 has been associated with having a negative impact on patients’ gut microbiome during both active disease and in the post-acute phase. In acute COVID-19, rapid alteration of composition was observed, showing one side reduction beneficial symbionts (e.g., Roseburia, Lachnospiraceae) other an increase opportunistic pathogens such as Enterococcus Proteobacteria. Alpha diversity tends to decrease, especially initially symptom onset hospital admission. Although clinical recovery appears align improved homeostasis, this process could take several weeks, even mild infections. Moreover, patients syndrome showed changes composition, specific signatures decreased respiratory function up 12 months following disease. Potential treatments, probiotic-based therapy, are under investigation. Open questions remain possibility use data predict progression potential confounders that may impair result interpretation concomitant therapies phase; reinfection, vaccines, occurrence novel conditions or diseases syndrome). Understanding relationships between dynamics contribute better understanding post-COVID pathogenesis inform personalized treatment can affect targets markers.

Язык: Английский

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