The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties

Microorganisms, Год журнала: 2024, Номер 12(2), С. 234 - 234

Опубликована: Янв. 23, 2024

Probiotics, known to be live microorganisms, have been shown improve or restore the gut microbiota, which in turn has linked improved health. It is believed that probiotics are modern equivalent of a panacea, with claims they may treat prevent different diseases both children and adults (e.g., from colic babies cardiovascular disease, respiratory infection, cancer adults). Ever since early 2000s, probiotic-based fermented foods had resurgence popularity, mostly due made regarding their health benefits. Fermented associated prevention irritable bowel syndrome, lactose intolerance, gastroenteritis, obesity, but also other conditions such as chronic diarrhea, allergies, dermatitis, bacterial viral infections, all closely related an unhealthy lifestyle. Recent ongoing developments microbiome/microbiota science given us new research directions for probiotics. The types, mechanisms, applications studied so far, those currently under study, great potential change scientific understanding probiotics’ nutritional human care. expansion fields study microbiome involvement its improvement foreshadow era significant changes. An expanding range candidate probiotic species emerging can address newly elucidated data-driven microbial niches host targets. In field, variants microbiome-modulating interventions being developed, including prebiotics, symbiotics, postbiotics, consortia, biotherapeutic products, genetically modified organisms, renewed interest polyphenols, fibers, ensure This manuscript aims analyze recent, emerging, anticipated trends (sources, doses, mechanism action, administered, side effects, risks) create vision development areas influence field.

Язык: Английский

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Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Viruses, Год журнала: 2023, Номер 15(1), С. 175 - 175

Опубликована: Янв. 7, 2023

The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease death. Understanding the risk factors is relevant both in setting at epidemiological level. Here, we provide an overview host, viral environmental that have been shown or (in some cases) hypothesized be associated with outcomes. considered detail include age frailty, genetic polymorphisms, biological sex (and pregnancy), co- superinfections, non-communicable comorbidities, immunological history, microbiota, lifestyle patient; variation infecting dose; socioeconomic factors; air pollution. For each category, compile (sometimes conflicting) evidence for association factor outcomes (including strength effect) outline possible action mechanisms. We also discuss complex interactions between various factors.

Язык: Английский

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Role of Probiotics in the Management of COVID-19: A Computational Perspective

Nutrients, Год журнала: 2022, Номер 14(2), С. 274 - 274

Опубликована: Янв. 10, 2022

Coronavirus disease 2019 (COVID-19) was declared a pandemic at the beginning of 2020, causing millions deaths worldwide. Millions vaccine doses have been administered worldwide; however, outbreaks continue. Probiotics are known to restore stable gut microbiota by regulating innate and adaptive immunity within gut, demonstrating possibility that they may be used combat COVID-19 because several pieces evidence suggesting has an adverse impact on dysbiosis. Thus, probiotics their metabolites with antiviral properties as adjunctive treatment COVID-19. Several clinical trials revealed efficacy in treating patients SARS-CoV-2. However, its molecular mechanism not unraveled. The availability abundant data resources computational methods significantly changed research finding insights between This review highlights approaches involving microbiome-based ensemble-driven docking approaches, well case study proving effects probiotic

Язык: Английский

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Immunomodulation of B Lymphocytes by Prebiotics, Probiotics and Synbiotics: Application in Pathologies

Nutrients, Год журнала: 2023, Номер 15(2), С. 269 - 269

Опубликована: Янв. 5, 2023

Introduction: Prebiotics, probiotics and synbiotics are known to have major beneficial effects on human health due their ability modify the composition function of gut mucosa, microbiota immune system. These components largely in a healthy population throughout different periods life confer homeostasis. Indeed, they can modulate by increasing bacteria strands that for health, such as Firmicute Bifidobacteria, decreasing harmful bacteria, Enteroccocus. Their immunomodulation properties been extensively studied innate cells (dendritic cells, macrophages, monocytes) adaptive (Th, Treg, B cells). They protolerogenic environment but also pro-inflammatory responses. Due all these effects, compounds investigated prevent or treat diseases, cancer, diabetes, allergies, autoimmune etc. Regarding literature, dendritic monocytes T presented number reviews, impact B-cell response has less widely discussed. Conclusions: For first time, we propose here review literature B-lymphocytes prebiotics, synbiotics, both conditions pathologies. Discussion: Promising studies performed animal models, highlighting potential intake diseases associated with immunomodulation, this needs be validated humans full characterization subsets not only humoral response.

Язык: Английский

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Gastrointestinal Manifestations of SARS-CoV-2: Transmission, Pathogenesis, Immunomodulation, Microflora Dysbiosis, and Clinical Implications

Viruses, Год журнала: 2023, Номер 15(6), С. 1231 - 1231

Опубликована: Май 24, 2023

The clinical manifestation of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in system humans is widely recognized. There increasing evidence suggesting that SARS-CoV-2 possesses capability to invade gastrointestinal (GI) system, leading symptoms such as vomiting, diarrhea, abdominal pain, and GI lesions. These subsequently contribute development gastroenteritis inflammatory bowel disease (IBD). Nevertheless, pathophysiological mechanisms linking these infection remain unelucidated. During infection, binds angiotensin-converting enzyme other host proteases tract during possibly causing damaging intestinal barrier stimulating factor production, respectively. COVID-19-induced IBD include inflammation, mucosal hyperpermeability, bacterial overgrowth, dysbiosis, changes blood fecal metabolomics. Deciphering pathogenesis COVID-19 understanding its exacerbation may provide insights into prognosis pave way for discovery potential novel targets prevention or treatment. Besides usual transmission routes, can also be transmitted via feces an infected person. Hence, it crucial implement preventive control measures order mitigate fecal-to-oral SARS-CoV-2. Within this context, identification diagnosis infections assume significance they facilitate early detection targeted therapeutics. present review discusses receptors, pathogenesis, SARS-CoV-2, with a particular focus on induction gut immune responses, influence microbes, therapeutic against IBD.

Язык: Английский

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Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial

Probiotics and Antimicrobial Proteins, Год журнала: 2021, Номер 15(3), С. 460 - 468

Опубликована: Окт. 13, 2021

Язык: Английский

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Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19

Clinics in Geriatric Medicine, Год журнала: 2022, Номер 38(3), С. 565 - 591

Опубликована: Июнь 20, 2022

Язык: Английский

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Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications

Metabolites, Год журнала: 2022, Номер 12(10), С. 912 - 912

Опубликована: Сен. 27, 2022

Increasing numbers of patients who recover from COVID-19 report lasting symptoms, such as fatigue, muscle weakness, dementia, and insomnia, known collectively post-acute COVID syndrome or long COVID. These symptoms have been examined in different studies found to influence multiple organs, sometimes resulting life-threating conditions. In this review, these are discussed connection the long-COVID-19 immune changes, highlighting oral psychiatric health, work focuses on gut microbiota’s link manifestations liver, heart, kidney, brain, spleen. A model is presented show biological clinical implications microbiota SARS-CoV-2 infection how they could possibly affect therapeutic aspects disease. Probiotics can support body’s systems fighting viral infections. This review current knowledge about use probiotics adjuvant therapies for that might help prevent complications.

Язык: Английский

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The effect of synbiotic adjunct therapy on clinical and paraclinical outcomes in hospitalized COVID‐19 patients: A randomized placebo‐controlled trial

Journal of Medical Virology, Год журнала: 2023, Номер 95(2)

Опубликована: Янв. 5, 2023

Therapeutic approaches with immune-modulatory effects such as probiotics and prebiotics adjuvant therapy may be essential to combat against COVID-19 pandemic. The present trial aimed reveal the efficacy of synbiotic supplementation on clinical paraclinical outcomes hospitalized patients. current randomized placebo-controlled enrolled 78 patients confirmed infection. Participants were randomly allocated intervention control groups that received or placebo capsules twice daily for 2 weeks, respectively. capsule contains multi-strain Lactobacillus (L.) rhamnosus, L. helveticus, casei, Bifidobacterium (B.) lactis, acidophilus, B. breve, bulgaricus, longum, plantarum, bifidum, gasseri, Streptococcus (S.) thermophilus (109 CFU), well fructooligosaccharides prebiotic agent. Besides features, levels proinflammatory interleukin-6 (IL-6), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), liver renal function markers, hematological parameters, assessed during follow-up. serum level IL-6 was significantly decreased in group compared after weeks (p = 0.002). A significant difference found regarding count white blood cells (WBC) within from pre post-treatment 0.004). ESR 0.935) CRP 0.952) had a higher reduction trend relative placebo, no between-group differences. Other findings statistical differences between groups. Our results provide support can effective modulate inflammatory responses

Язык: Английский

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The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review

Life Sciences, Год журнала: 2024, Номер 342, С. 122535 - 122535

Опубликована: Фев. 24, 2024

Emerging evidence highlights the role of COVID-19 in instigating gut dysbiosis, with repercussions on disease severity and bidirectional gut-organ communication involving lung, heart, brain, liver. This study aims to evaluate efficacy probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT) addressing dysbiosis associated COVID-19, as well their impact related clinical outcomes. We systematically review 27 studies exploring different microbiome-modulating therapies: potential interventions for COVID-19. The probiotics synbiotics investigated encompassed a spectrum eight bacterial fungal genera, namely Lactobacillus, Bifidobacterium, Streptococcus, Enterococcus, Pediococcus, Bacillus, Saccharomyces, Kluyveromyces. Noteworthy prebiotics employed these included chestnut tannin, galactooligosaccharides, fructooligosaccharides, xylooligosaccharide, resistant dextrin. majority biotics exhibited positive effects patients, manifesting symptom alleviation, inflammation reduction, notable decreases mortality rates. Five reported death rates, showing an average ranging from 0 % 11 intervention groups, compared 3 30 control groups. Specifically, demonstrated diminishing duration symptoms while significantly accelerating viral symptomatic remission. FMT emerged particularly effective strategy, successfully restoring ameliorating gastrointestinal disorders. insights gleaned this contribute our broader comprehension therapeutic COVID-19-related mitigating secondary multi-organ complications.

Язык: Английский

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