Function of microRNA‑124 in the pathogenesis of cancer (Review)

International Journal of Oncology, Год журнала: 2023, Номер 64(1)

Опубликована: Ноя. 29, 2023

Non‑coding RNAs with a length of 22‑24 nt are known as microRNAs (miRNAs or miRs), which critical regulators protein translation. Over the past 10 years, roles miRNAs have been extensively investigated in several human cancer types. There is evidence to indicate that regulate gene expression by concentrating on number substances an impact physiology and development cells. Thus, regarded effective targets for further studies design novel therapeutic strategies. Hepatocellular carcinoma, breast, prostate, ovarian only few cancers miR‑124 suppresses. Furthermore, it has shown linked aggressive spread malignancies. The aim present review was clarify highlight role progression cancer, emphasizing recent research illustrating how used agent against well diagnostic potential, regulatory mechanisms clinical application miR‑124.

Язык: Английский

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Curcumin and Its Analogs as Potential Epigenetic Modulators: Prevention of Diabetes and Its Complications

Pharmacology, Год журнала: 2021, Номер 107(1-2), С. 1 - 13

Опубликована: Дек. 15, 2021

<b><i>Background:</i></b> The pathobiology of diabetes and associated complications has been widely researched in various countries, but effective prevention treatment methods are still insufficient. Diabetes is a metabolic disorder carbohydrates, fats, proteins caused by an absence insulin or resistance, which mediates increase oxidative stress, release inflammatory factors, macro- micro-circulation dysfunctions, ultimately developing into diverse complications. <b><i>Summary:</i></b> In the last decade through pathogenesis research, epigenetics found to affect diseases. Particularly, DNA methylation, histone acetylation, miRNAs promote inhibit regulating expression related factors. Curcumin wide range beneficial pharmacological activities, including anti-inflammatory, anti-oxidation, anticancer, anti-diabetes, anti-rheumatism, increased immunity. <b><i>Key Messages:</i></b> this review, we discuss effects curcumin analogs on epigenetics, summarize preclinical clinical researches for its terms management complications, may provide insight development targeted therapy endocrine

Язык: Английский

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Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions

Neural Regeneration Research, Год журнала: 2022, Номер 17(11), С. 2325 - 2325

Опубликована: Янв. 1, 2022

Precise tuning of gene expression, accomplished by regulatory networks transcription factors, epigenetic modifiers, and microRNAs, is crucial for the proper neural development function brain cells. The SOX factors are involved in regulating diverse cellular processes during embryonic adult neurogenesis, such as maintaining cell stemness, proliferation, fate decisions, terminal differentiation into neurons glial MicroRNAs represent a class small non-coding RNAs that play important roles regulation expression. Together with other microRNAs regulate different neurogenesis orchestrate spatial temporal expression neurodevelopment. emerging data point to complex network between govern distinct activities developing brain. Deregulated SOX/microRNA interplay signaling pathways influence homeostasis plasticity has been revealed various pathologies, including neurodegenerative disorders, traumatic injury, cancer. Therapeutic strategies target have emerged recent years promising tool tissue regeneration enhance neurorestoration. Numerous studies confirmed interactions SOX-specific mRNAs key features glioblastoma. Keeping mind genes development, we focus this review on SOX/microRNAs adulthood physiological pathological conditions. Special was made their pathologies summarize current knowledge highlight potential future molecular therapies.

Язык: Английский

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Role of death-associated protein kinase 1 (DAPK1) in retinal degenerative diseases: an in-silico approach towards therapeutic intervention

Journal of Biomolecular Structure and Dynamics, Год журнала: 2023, Номер 42(11), С. 5686 - 5698

Опубликована: Июнь 30, 2023

The Death-associated protein kinase 1 (DAPK1) has emerged as a crucial player in the pathogenesis of degenerative diseases. As serine/threonine family member, DAPK1 regulates critical signaling pathways, such apoptosis and autophagy. In this study, we comprehensively analyzed interactors enriched molecular functions, biological processes, phenotypic expression, disease associations, aging signatures to elucidate networks DAPK1. Furthermore, employed structure-based virtual screening approach using PubChem database, which enabled identification potential bioactive compounds capable inhibiting DAPK1, including caspase inhibitors synthetic analogs. Three selected compounds, CID24602687, CID8843795, CID110869998, exhibited high docking affinity selectivity towards were further investigated dynamics simulations understand their binding patterns. Our findings establish connection between retinal diseases highlight these for development novel therapeutic strategies. This study provides valuable insights into mechanisms underlying DAPK1-related diseases, offers new opportunities discovery effective treatments degeneration.Communicated by Ramaswamy H. Sarma

Язык: Английский

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microRNA-124 directly suppresses Nodal and Notch to regulate mesodermal development

Developmental Biology, Год журнала: 2023, Номер 502, С. 50 - 62

Опубликована: Июль 5, 2023

Язык: Английский

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