Pharmaceuticals,
Год журнала:
2023,
Номер
16(2), С. 151 - 151
Опубликована: Янв. 19, 2023
Dementia,
most
often
associated
with
neurodegenerative
diseases,
affects
millions
of
people
worldwide,
predominantly
the
elderly.
Unfortunately,
no
treatment
is
still
available.
Therefore,
there
an
urgent
need
to
address
this
situation.
This
review
presents
state
art
drug
discovery
and
developments
in
targeting
dementia.
Several
approaches
are
discussed,
such
as
repurposing,
use
small
molecules,
phosphodiesterase
inhibitors.
Furthermore,
also
provides
insights
into
clinical
trials
these
molecules.
Emphasis
has
been
placed
on
molecules
multi-target-directed
ligands,
well
disease-modifying
therapies.
Finally,
attention
drawn
possibilities
applications
nanotechnology
managing
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Дек. 13, 2023
Neurons
and
their
connecting
axons
gradually
degenerate
in
neurodegenerative
diseases
(NDs),
leading
to
dysfunctionality
of
the
neuronal
cells
eventually
death.
Drug
delivery
for
treatment
effected
nervous
system
is
notoriously
complicated
because
presence
natural
barriers,
i.e.,
blood-brain
barrier
blood
cerebrospinal
fluid
barrier.
Palliative
care
currently
standard
many
diseases.
Therefore,
programs
that
target
disease's
origin
rather
than
its
symptoms
are
recommended.
Nanotechnology-based
drug
platforms
offer
an
innovative
way
circumvent
these
obstacles
deliver
medications
directly
central
system,
thereby
enabling
several
common
neurological
problems,
Alzheimer's,
Parkinson's,
Huntington's,
amyotrophic
lateral
sclerosis.
Interestingly,
combination
nanomedicine
gene
therapy
enables
targeting
selective
mutant
genes
responsible
progression
NDs,
which
may
provide
a
much-needed
boost
struggle
against
Herein,
we
discussed
various
obstacles,
followed
by
detailed
insight
into
recently
developed
techniques
restore
function
via
differentiation
neural
stem
cells.
Moreover,
comprehensive
background
on
role
controlling
neurogenesis
explained.
Additionally,
numerous
phytoconstituents
with
neuroprotective
properties
molecular
targets
identification
management
NDs
also
deliberated.
Furthermore,
ongoing
clinical
trials
marketed
products
provided
this
manuscript.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 611 - 626
Опубликована: Фев. 1, 2023
Abstract:
Neurodegeneration
is
characterized
by
progressive,
disabling,
and
incurable
neurological
disorders
with
the
massive
loss
of
specific
neurons.
As
one
most
promising
potential
therapeutic
strategies
for
neurodegenerative
diseases,
stem
cell
therapy
exerts
beneficial
effects
through
different
mechanisms,
such
as
direct
replacement
damaged
or
lost
cells,
secretion
neurotrophic
growth
factors,
decreased
neuroinflammation,
activation
endogenous
cells.
However,
poor
survival
differentiation
rates
transplanted
insufficient
homing
ability,
difficulty
tracking
after
transplantation
limit
their
further
clinical
use.
The
rapid
development
nanotechnology
provides
many
nanomaterials
biomedical
applications,
which
already
have
applications
in
disease
treatment
seem
to
be
able
compensate
some
deficiencies
therapy,
transport
cells/genes/drugs,
regulating
differentiation,
real-time
therapy.
Therefore,
nanotherapeutic
combined
a
approach
treating
diseases.
present
review
systematically
summarizes
recent
advances
therapeutics
highlights
how
they
can
improve
efficacy
Keywords:
nanotherapeutic,
nanomaterials,
diseases
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2441 - 2467
Опубликована: Март 1, 2024
Abstract:
New
nanotechnology
strategies
for
enhancing
drug
delivery
in
brain
disorders
have
recently
received
increasing
attention
from
designers.
The
treatment
of
neurological
conditions,
including
tumors,
stroke,
Parkinson's
Disease
(PD),
and
Alzheimer's
disease
(AD),
may
be
greatly
influenced
by
nanotechnology.
Numerous
studies
on
neurodegeneration
demonstrated
the
effective
application
nanomaterials
illnesses.
Nanocarriers
(NCs)
made
it
easier
to
deliver
drugs
precisely
where
they
are
needed.
Thus,
most
use
is
various
diseases,
as
this
amplifies
overall
impact
medication
emphasizes
significance
nanotherapeutics
through
gene
therapy,
enzyme
replacement
blood-barrier
mechanisms.
Recent
advances
led
development
multifunctional
nanotherapeutic
agents,
a
promising
disorders.
This
novel
method
reduces
side
effects
improves
outcomes.
review
critically
assesses
efficient
nano-based
systems
light
obstacles
outstanding
achievements.
that
transfer
medications
across
blood-brain
barrier
nano-assisted
therapies,
nano-immunotherapy,
nano-gene
nano
scaffolds,
3D
6D
printing,
been
widely
explored
study
aimed
evaluate
existing
literature
regarding
can
penetrate
(BBB)
therapeutic
agents
treat
Keywords:
delivery,
nanomedicine,
nano-therapeutics,
nanocarriers,
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
98(4), С. 1169 - 1179
Опубликована: Апрель 9, 2024
Alzheimer's
disease
(AD)
is
a
complex
neurodegenerative
disorder
characterized
by
the
accumulation
of
neurofibrillary
tangles
and
amyloid-β
plaques.
Recent
research
has
unveiled
pivotal
role
insulin
signaling
dysfunction
in
pathogenesis
AD.
Insulin,
once
thought
to
be
unrelated
brain
function,
emerged
as
crucial
factor
neuronal
survival,
synaptic
plasticity,
cognitive
processes.
Insulin
downstream
molecules
are
found
mainly
hippocampus
cortex.
Some
responsible
for
GSK-3β,
Akt,
PI3K,
IRS.
Irregularities
or
resistance
may
arise
from
changes
phosphorylation
levels
key
molecules,
which
can
influenced
both
stimulation
inactivity.
This,
turn,
believed
contributing
development
AD,
oxidative
stress,
neuroinflammation,
other
pathological
hallmarks.
Furthermore,
this
route
known
indirectly
Nrf2,
NF-κB,
caspases.
This
mini-review
delves
into
intricate
relationship
between
exploring
how
disruptions
pathway
contribute
progression.
Moreover,
we
examine
recent
advances
drug
delivery
systems
designed
target
AD
treatment.
From
oral
innovative
nanoparticle
approaches
intranasal
administration,
these
strategies
hold
promise
mitigating
impact
on
review
consolidates
current
knowledge
shed
light
potential
interventions
targeted
therapeutic
options
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101457 - 101457
Опубликована: Янв. 5, 2025
Central
nervous
system
(CNS)
diseases
are
a
major
cause
of
disability
and
death
worldwide.
Due
to
the
blood-brain
barrier
(BBB),
drug
delivery
for
CNS
is
extremely
challenging.
Nano-delivery
systems
can
overcome
limitations
BBB
deliver
drugs
CNS,
improve
ability
target
brain
provide
potential
therapeutic
methods
diseases.
At
same
time,
choice
different
(bypassing
or
crossing
BBB)
further
optimize
effect
nano-drug
system.
This
article
reviews
nano-delivery
way
enters
brain.
Different
kinds
nanoparticles
were
discussed
in
depth.
