Hygiene and Sanitation,
Год журнала:
2024,
Номер
103(10), С. 1230 - 1234
Опубликована: Ноя. 19, 2024
Introduction.
Examining
peculiarities
of
neuroimmune
profiles
and
candidate
gene
polymorphism
is
a
relevant
trend
in
identifying
markers
effects
sensitivity
to
chemical
exposures
northern
areas.
Materials
methods.
We
examined
one
thousand
two
hundred
fifty
three
children
residing
North-Eastern
South-Eastern
Siberia.
Blood
benzo(a)pyrene
levels
were
detected
by
HPLC.
The
ANKK1/DRD2
(rs18004976)
was
studied
using
real-time
PCR.
IgG
identified
allergosorbent
testing.
Dopamine
ELISA.
Results.
Exposure
airborne
benz(a)pyrene
an
industrial
center
Siberia
at
the
dose
0.0073
µg/(kg
∙
day)
causes
elevated
risk
specific
hapten
hypersensitivity
(IgG
benzo(a)pyrene),
inhibition
dopaminergic
regulation
(dopamine
deficiency),
contamination
biological
media.
changes
are
similar
those
established
exposed
this
polycyclic
aromatic
hydrocarbon
0.0858
Limitations.
sample
needs
expanding
any
results
obtained
further
observations
should
be
verified.
Conclusion.
Children
low
doses
(0.0073
day))
have
risks
disorders
profile
associated
with
T-allele
TT
genotype
(rs1800497)
(OR
=2.17
–
2.83,
p<0.05)
(hyperproduction
benzo(a)pyrene,
dopamine
which
comparable
C-allele
CC-genotype
(OR=1.69
1.72,
under
exposure
µg
/(kg
This
indicates
higher
body
climatic
conditions
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Март 14, 2022
Many
studies
showed
that
dopamine
receptors
(DRs)
agonists
have
anti-inflammatory
effects.
Rotigotine,
a
non-ergot
receptor
agonist,
mainly
actives
DRD2/DRD3/DRD1.
Rotigotine
extended-release
microspheres
(RoMS)
are
sustained-release
formulation
can
release
sustainably
rotigotine
for
more
than
7
days
after
single
dose
of
RoMS.
This
study
aimed
to
investigate
whether
RoMS
attenuate
the
lipopolysaccharide
(LPS)-induced
liver
injury
mice.
The
was
evaluated
by
assaying
serum
transaminase
and
observing
histopathological
changes.
levels
pro-inflammatory
cytokines
in
were
also
detected.
Western
blot
employed
assay
expression
proteins
Akt/NF-κB
pathway.
results
pre-administration
with
could
inhibit
increase
induced
LPS,
alleviate
pathological
damage
tissue,
decrease
tumor
necrosis
factor-α
interleukin-6.
In
addition,
decreased
Toll-like
4
protein
tissue.
mitigated
activating
DRs
negatively
regulating
β-arrestin2-dependent
signaling
effects
be
weakened
or
abolished
specific
DRD2
antagonist,
R121.
conclusion,
activation
inhibited
releases
alleviated
immune-mediated
LPS
mechanism
may
related
regulation
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(4)
Опубликована: Июнь 1, 2024
Dendritic
cells
(DCs)
are
known
as
antigen-presenting
that
capable
of
regulating
immune
responses.
DCs
and
T
can
interact
mutually
to
induce
antigen-specific
T-cell
Cabergoline,
which
is
a
dopamine
(DA)
receptor
agonist,
seems
implement
anti-inflammatory
properties
in
the
system,
therefore
present
study
impact
DA
agonist
cabergoline
on
monocyte-derived
(moDCs)
was
assessed.
Immature
moDCs
were
treated
with
lipopolysaccharide
produce
mature
(mDCs).
The
expression
DCs'
related
surface
markers
namely:
CD11c,
HLA-DR,
CD86
measured
by
utilizing
flow
cytometry.
Real-time
PCR
technique
choice
determine
levels
at
diverse
inflammatory
factors
cabergoline-treated
control
mDC
groups
expressed.
displayed
significant
decrease
HLA-DR
expression,
linked
maturation
antigen
presentation,
respectively.
In
addition,
cabergoline-mDC
group
showed
considerable
decline
terms
IL-10,
TGF-β,
IDO
genes
expressed,
an
increase
TNF-α
IL-12
comparison
group.
Our
findings
revealed
immunomodulatory
agent
relatively
shift
into
immunogenic
state,
there
requirement
for
further
investigations
evaluate
effects
cell
responses
vitro,
also
various
diseases
including
cancer
animal
models.
Hygiene and Sanitation,
Год журнала:
2024,
Номер
103(10), С. 1230 - 1234
Опубликована: Ноя. 19, 2024
Introduction.
Examining
peculiarities
of
neuroimmune
profiles
and
candidate
gene
polymorphism
is
a
relevant
trend
in
identifying
markers
effects
sensitivity
to
chemical
exposures
northern
areas.
Materials
methods.
We
examined
one
thousand
two
hundred
fifty
three
children
residing
North-Eastern
South-Eastern
Siberia.
Blood
benzo(a)pyrene
levels
were
detected
by
HPLC.
The
ANKK1/DRD2
(rs18004976)
was
studied
using
real-time
PCR.
IgG
identified
allergosorbent
testing.
Dopamine
ELISA.
Results.
Exposure
airborne
benz(a)pyrene
an
industrial
center
Siberia
at
the
dose
0.0073
µg/(kg
∙
day)
causes
elevated
risk
specific
hapten
hypersensitivity
(IgG
benzo(a)pyrene),
inhibition
dopaminergic
regulation
(dopamine
deficiency),
contamination
biological
media.
changes
are
similar
those
established
exposed
this
polycyclic
aromatic
hydrocarbon
0.0858
Limitations.
sample
needs
expanding
any
results
obtained
further
observations
should
be
verified.
Conclusion.
Children
low
doses
(0.0073
day))
have
risks
disorders
profile
associated
with
T-allele
TT
genotype
(rs1800497)
(OR
=2.17
–
2.83,
p<0.05)
(hyperproduction
benzo(a)pyrene,
dopamine
which
comparable
C-allele
CC-genotype
(OR=1.69
1.72,
under
exposure
µg
/(kg
This
indicates
higher
body
climatic
conditions
