S-nitrosoglutathione releasing nano-micron combination hy-drogel enhances cutaneous wound healing via promoting an-giogenesis and collagen deposition

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Апрель 7, 2025

Nitric oxide (NO) is essential for wound healing, promoting angiogenesis and collagen deposition. This study investigates a novel dual-matrix nanocomposite hydrogel incorporating S-nitrosoglutathione (GSNO), physiological NO donor, to enhance cutaneous healing. GSNO was encapsulated in ammonio methacrylate copolymer nanoparticles embedded an alginate-based matrix, achieving controlled release. GSNO-loaded were prepared using solvent displacement evaporation methods, resulting spherical, well-distributed positively charged particles. These cross-linked with negatively alginic acid form hydrogel. The hydrophobic protected from degradation, while the hydrophilic alginate matrix sustained release of active up 10 h, haemostasis maintaining moist environment. exhibited good biocompatibility human fibroblasts significantly enhanced repair by fibroblast formation, neovascularisation deposition, as demonstrated haematoxylin eosin staining Masson's trichrome staining. In conclusion, accelerated healing process enhancing offering promising strategy improving

Язык: Английский

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Nitric oxide: a gas transmitter in healthy and diseased skin

Medical Gas Research, Год журнала: 2025, Номер 15(4), С. 520 - 528

Опубликована: Апрель 29, 2025

Numerous physiological processes in the human skin are mediated by nitric oxide, a gaseous signalling molecule. Almost every type of cell may produce it is possible to generate oxide without need enzymes. Nitric plays crucial role regulating apoptosis, keratinocyte differentiation and proliferation, protective properties epidermal barrier, structure functions microcirculatory bed. involved immunological inflammatory responses, hair growth regulation, wound healing processes. It mediates ultraviolet-induced such as erythema edema development participates melanogenesis. Furthermore, ability bind reactive oxygen species prevent lipid peroxidation gives antioxidant qualities. This coordinated action on gene expression membrane integrity effectively protects cells from ultraviolet A-induced apoptosis necrosis. can be considered molecule that inhibits cancer photoaging. directly harms microorganisms indirectly activates immune system, exhibiting antibacterial, antiviral, antifungal Notably, effective against antibiotics-resistant bacteria. All aforementioned findings suggest mediator protect function.

Язык: Английский

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Evolving spectrum of diabetic wound: Mechanistic insights and therapeutic targets

World Journal of Diabetes, Год журнала: 2022, Номер 13(9), С. 696 - 716

Опубликована: Сен. 9, 2022

Diabetes mellitus is a chronic metabolic disorder resulting in an increased blood glucose level and prolonged hyperglycemia, causes long term health conse-quences. Chronic wound frequently occurring diabetes patients due to compromised healing capability. Management of wounds diabetic remains clinical challenge despite many advancements the field science technology. Increasing evidence indicates that alteration biochemical milieu from inflammatory cytokines matrix metalloproteinase, decrease fibroblast keratinocyte functioning, neuropathy, altered leukocyte infection, etc., plays significant role impaired people. Apart current pharmacotherapy, different other approaches like use conventional drugs, antidiabetic medication, antibiotics, debridement, offloading, platelet-rich plasma, growth factor, oxygen therapy, negative pressure low-level laser, extracorporeal shock wave bioengineered substitute can be considered management wounds. Drugs/therapeutic strategy induce angiogenesis collagen synthesis, inhibition MMPs, reduction oxidative stress, controlling increase factors, regulate cytokines, cause NO induction, proliferation, control microbial infections are important wound. Further, medicinal plants and/or phytoconstituents also offer viable alternative treatment The focus present review highlight molecular cellular mechanisms, discuss drug targets strategies involved

Язык: Английский

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3D printable, injectable amyloid-based composite hydrogel of bovine serum albumin and aloe vera for rapid diabetic wound healing

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(34), С. 8142 - 8158

Опубликована: Янв. 1, 2023

Protein-based biomaterials, particularly amyloids, have sparked considerable scientific interest in recent years due to their exceptional mechanical strength, excellent biocompatibility and bioactivity. In this work, we synthesized a novel amyloid-based composite hydrogel consisting of bovine serum albumin (BSA) aloe vera (AV) gel utilize the medicinal properties AV circumvent its frangibility. The demonstrated an porous structure, self-fluorescence, non-toxicity, controlled rheological properties. Moreover, possesses inherent antioxidant antibacterial properties, which accelerate rapid healing wounds. vitro wound capabilities were evaluated using 3T3 fibroblast cells. efficacy accelerating chronic via collagen crosslinking was investigated through vivo experiments diabetic mouse skin model. findings indicate that hydrogel, when applied, promotes by inducing deposition upregulating expression vascular endothelial growth factor (VEGF) receptors. We also demonstrate feasibility 3D printing BSA-AV can be tailored treat various types wound. printed exhibits shape fidelity utilized for personalized treatment healing. Taken together, has great potential as bio-ink tissue engineering dermal substitute customizable regeneration.

Язык: Английский

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Multifunctional electrospun membranes with hydrophilic and hydrophobic gradients property for wound dressing

Colloids and Surfaces B Biointerfaces, Год журнала: 2023, Номер 225, С. 113276 - 113276

Опубликована: Март 24, 2023

Язык: Английский

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