ACS Applied Nano Materials, Год журнала: 2024, Номер 7(19), С. 23062 - 23075
Опубликована: Окт. 1, 2024
Язык: Английский
Gels, Год журнала: 2024, Номер 10(2), С. 147 - 147
Опубликована: Фев. 14, 2024
Wound healing is a physiological process occurring after the onset of skin lesion aiming to reconstruct dermal barrier between external environment and body. Depending on nature duration process, wounds are classified as acute (e.g., trauma, surgical wounds) chronic diabetic ulcers) wounds. The latter take several months heal or do not (non-healing wounds), usually prone microbial infection represent an important source morbidity since they affect millions people worldwide. Typical wound treatments comprise debridement, grafts/flaps) non-surgical topical formulations, dressings) methods. Modern experimental approaches include among others three dimensional (3D)-(bio)printed dressings. present paper reviews recently developed 3D (bio)printed hydrogels for applications, especially focusing results their in vitro vivo assessment. advanced hydrogel constructs were printed using different types bioinks natural and/or synthetic polymers mixtures with biological materials) printing methods extrusion, digital light processing, coaxial microfluidic bioprinting, etc.) incorporated various bioactive agents growth factors, antibiotics, antibacterial agents, nanoparticles, cells fibroblasts, keratinocytes, mesenchymal stem cells, endothelial etc.).
Язык: Английский
Процитировано
20
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160379 - 160379
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(14)
Опубликована: Фев. 2, 2024
Abstract The limitations of protein‐based hydrogels, including their insufficient mechanical properties and restricted biological functions, arise from the highly specific functions proteins as natural building blocks. A potential solution to overcome these shortcomings is development protein–protein which integrate structural functional proteins. In this study, a hydrogel formed by crosslinking bovine serum albumin (BSA) genetically engineered intrinsically disordered collagen‐like protein (CLP) through Ag─S bonding introduced. approach involves thiolating lysine residues BSA CLP with Ag + ions, utilizing thiolation free‐cysteines CLP. resulting hydrogels exhibit exceptional properties, notable plasticity, inherent self‐healing capabilities, gel–sol transition in response redox conditions. comparison standalone demonstrate enhanced cellular viability, improved migration. vivo experiments provide conclusive evidence accelerated wound healing, observed not only murine models streptozotocin (Step)‐induced diabetes but also zebrafish subjected UV‐burn injuries. Detailed mechanistic insights, combined assessments proinflammatory cytokines expression epidermal differentiation‐related proteins, robustly validate hydrogel's effectiveness promoting repair.
Язык: Английский
Процитировано
11
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Апрель 22, 2025
ABSTRACT Recent advancements in hydrogel‐based flexible materials have revolutionized wound healing and monitoring strategies. These offer promising solutions for medical treatment real‐time diagnostics. Their rich water content, biocompatibility, tunable properties closely mimic the natural extracellular matrix, supporting regeneration. Unlike traditional materials, systems address critical issues such as material stability toxicity while integrating advanced devices. This review highlights latest innovations materials. It focuses on flexibility, potential integration with smart systems. The covers design principles fabrication techniques nanofibers, elastomers, conducting polymers. also discusses development of electronic skin innovative dressings. In addition, explains how sensing capabilities, stimuli‐responsive functions, antibacterial agents are incorporated into these Finally, article examines challenges future directions field. emphasizes transformative multifunctional improving continuous monitoring.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(8), С. 2070 - 2082
Опубликована: Янв. 1, 2024
An innovative wound microenvironment self-adaptive hydrogel, that encapsulates drug-loaded liposomes was developed to promote the healing of diabetic wounds.
Язык: Английский
Процитировано
7
Heliyon, Год журнала: 2024, Номер 10(20), С. e38481 - e38481
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
7
Materials Advances, Год журнала: 2024, Номер 5(10), С. 4078 - 4090
Опубликована: Янв. 1, 2024
The review discusses advancements in amyloid fibril-based materials and their applications healthcare, sensing, the environment. These biomaterials are sustainable greener alternatives to conventional synthetic materials.
Язык: Английский
Процитировано
5
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 705, С. 135553 - 135553
Опубликована: Окт. 13, 2024
Язык: Английский
Процитировано
3
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Abstract 3D printing of protein materials for creating bioactive scaffolds has attracted significant interest. However, achieving controllable and stable while replicating the ordered structure found in natural remains a key challenge. Herein, universally applicable temperature‐dependent aggregation (TPA) strategy is reported to manipulate unfolding, relaxation, reorganization chains enable amyloid‐like proteins. The disruption internal disulfide bonds induces unfolding relaxation protein, leading formation an amorphous sol through chain entanglement as primary cross‐linking points. These relaxed further aggregate conformational transition initiate rich β‐sheet structures at high temperature, resulting gel with nanocrystals serving secondary This facilitates precise extrusion‐based proteinaceous hierarchically structure. biomedical potential this 3D‐printed scaffold preliminarily validated its biomineralization capability following application bone tissue regeneration using rat skull defect models. demonstrates facile approach structural proteins vitro holds great field protein‐based scaffolds.
Язык: Английский
Процитировано
3
The Journal of Chemical Physics, Год журнала: 2025, Номер 162(2)
Опубликована: Янв. 8, 2025
Silk-fibroin hydrogels have gained considerable attention in recent years for their versatile biomedical applications. The physical properties of a complex hydrogel, comprising silk fibroin and riboflavin, surpass those the fibroin-hydrogel without additives. This study investigates fibroin–riboflavin (silk–RIB) hydrogel at atomistic level to uncover molecular structures chemical characteristics specific riboflavin molecules an aqueous medium. interplay between hydrophilic hydrophobic polymers facilitates formation solubilized fiber, which subsequently evolves into nano-scale over time. Eventually, interlinked RIB stacks form scaffold that not only accommodates aggregates but also encloses water pockets, preserving moisture enhancing thermal conductivity hydrogel. To explore retention role ions, two sets simulations semi-hydrated presence absence ions are conducted. significantly influences dynamics fibroin. Favorable interactions with impede unrestricted diffusion these larger molecules, potentially leading stable structure capable retaining prolonged duration. complete removal results further shrinkage anhydrous silk–RIB or xerogel (XG), yet its porosity structural integrity remain intact. These findings offer valuable insights behavior XG, paving way materials engineering environments develop devices customized functional properties.
Язык: Английский
Процитировано
0