Progress in approved drugs from natural product resources

Chinese Journal of Natural Medicines, Год журнала: 2024, Номер 22(3), С. 195 - 211

Опубликована: Март 1, 2024

Язык: Английский

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A Versatile Glycopeptide Hydrogel Promotes Chronic Refractory Wound Healing Through Bacterial Elimination, Sustained Oxygenation, Immunoregulation, and Neovascularization

Advanced Functional Materials, Год журнала: 2023, Номер 33(49)

Опубликована: Июль 26, 2023

Abstract Chronic refractory wounds have become a severe threat to public health and are characterized by repeated bacterial infections, persistent hypoxia, abnormal immune regulation, obstruction of angiogenesis. However, current treatment strategies usually perform only one or two therapeutic functions cannot satisfy the dynamic complex demands chronic wound healing. Herein, versatile Schiff base borate ester cross‐linked glycopeptide hydrogel is prepared from phenylboronic acid‐grafted ε‐polylysine (EPBA), epigallocatechin‐3‐gallate (EGCG), oxidized alginate. Customized polydopamine‐coated honeycomb MnO 2 nanoparticles loaded with herb‐derived salvianolic acid B (PHMS) embedded into before gelation. Under distinct acidic oxidative microenvironment wounds, gradually dissociates, released EPBA effectively eliminates bacteria, while EGCG PHMS eradicates reactive oxygen nitrogen species, promotes M2 polarization macrophages, continuously generates oxygen. Then further disintegrates, angiogenesis through PI3K/Akt pathway. The accelerates Staphylococcus aureus ‐infected diabetic cutaneous repair in vivo promising candidate dressing for

Язык: Английский

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Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Язык: Английский

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Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence

Metabolites, Год журнала: 2025, Номер 15(2), С. 124 - 124

Опубликована: Фев. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Язык: Английский

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Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 31, 2025

Neurological disorders pose significant global public health challenges, with a rising prevalence and complex pathophysiological mechanisms that impose substantial social economic burdens. Traditional Chinese Medicine (TCM), its holistic approach multi-target effects, has gained increasing attention in the treatment of neurological diseases. This review explores bioactive compounds derived from herbal plants, focusing on their action, underlying pathways, potential applications functional food development. The highlights neuroprotective properties flavonoids, alkaloids, polysaccharides, polyphenols found key TCM herbs such as Scutellaria baicalensis , Salvia miltiorrhiza Ligusticum chuanxiong Gastrodia elata . These have demonstrated anti-inflammatory, antioxidant, neurogenic making them promising candidates for prevention conditions, including Alzheimer’s disease (AD), Parkinson’s (PD), depression. Furthermore, synergistic effects formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially combating neurodegenerative also discusses challenges future directions integrating these into foods dietary supplements, aiming to improve enhance clinical outcomes. Ultimately, this work aims provide valuable insights TCM-based interventions promoting well-being addressing burden disorders.

Язык: Английский

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Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke

Neural Regeneration Research, Год журнала: 2023, Номер 19(3), С. 519 - 528

Опубликована: Июль 20, 2023

Abstract Local ischemia often causes a series of inflammatory reactions when both brain immune cells and the peripheral response are activated. In human body, gut lung regarded as key reactional targets that initiated by ischemic attacks. Mucosal microorganisms play an important role in regulation metabolism affect blood-brain barrier permeability. addition to relationship between organs central areas intestine also interact among each other. Here, we review molecular cellular mechanisms involved pathways inflammation across gut-brain axis lung-brain axis. We found abnormal intestinal flora, microenvironment, infection, chronic diseases, mechanical ventilation can worsen outcome stroke. This introduces influence on lungs after stroke, highlighting bidirectional feedback effect gut, lungs, brain.

Язык: Английский

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Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

Phytotherapy Research, Год журнала: 2023, Номер 38(2), С. 880 - 911

Опубликована: Дек. 13, 2023

Abstract Current pharmaceutical research is energetically excavating the pharmacotherapeutic role of herb‐derived ingredients in multiple malignancies’ targeting. Luteolin one major phytochemical components that exist various traditional Chinese medicine or medical herbs. Mounting evidence reveals this phytoconstituent endows prominent therapeutic actions on diverse malignancies, with underlying mechanisms, combined medication strategy, and pharmacokinetics elusive. Additionally, clinical trial investigation luteolin remain to be systematically delineated. The present review aimed comprehensively summarize updated information regard anticancer mechanism, strategies, pharmacokinetics, trials, researches luteolin. survey corroborates executes effects mainly by dampening proliferation invasion, spurring apoptosis, intercepting cell cycle, regulating autophagy immune, inhibiting inflammatory response, inducing ferroptosis, pyroptosis, as well epigenetic modification, so on. can applied combination numerous anticarcinogens natural synergistically enhance efficacy malignancies while reducing adverse reactions. For has an unfavorable oral bioavailability, it persists plasma glucuronides sulfate‐conjugates after being metabolized, regarded potent inhibitors OATP1B1 OATP2B1, which may messed pharmacokinetic interactions miscellaneous bioactive substances vivo. Besides, innovation leading‐edge drug delivery systems such host–guest complexes, nanoparticles, liposomes, nanoemulsion, microspheres, hydrogels are beneficial exploitation luteolin‐based products. Moreover, some registered trials carried out, yet should continuously promoted.

Язык: Английский

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Anti-inflammatory effects of quinolinyl analog of resveratrol targeting TLR4 in MCAO/R ischemic stroke rat model

Phytomedicine, Год журнала: 2024, Номер 128, С. 155344 - 155344

Опубликована: Янв. 8, 2024

Язык: Английский

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Hydroxysafflor yellow A attenuates the inflammatory response in cerebral ischemia–reperfusion injured mice by regulating microglia polarization per SIRT1-mediated HMGB1/NF-κB signaling pathway

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 114040 - 114040

Опубликована: Янв. 10, 2025

Язык: Английский

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Ginsenoside Rk2 alleviates hepatic ischemia/reperfusion injury by enhancing AKT membrane translocation and activation

MedComm, Год журнала: 2025, Номер 6(1)

Опубликована: Янв. 1, 2025

Hepatic ischemia-reperfusion injury (IRI) poses a significant threat to clinical outcomes and graft survival during hemorrhagic shock, hepatic resection, liver transplantation. Current pharmacological interventions for IRI are inadequate. In this study, we identified ginsenoside Rk2 (Rk2), rare dehydroprotopanaxadiol saponin, as promising agent against through high-throughput screening. The effects molecular mechanisms of on were further evaluated elucidated in vitro vivo. significantly reduced inflammation apoptosis caused by oxygen-glucose deprivation reperfusion hepatocytes dose dependently protected I/R-induced mice. Integrated approaches, including network pharmacology, docking, transcriptome analysis, isothermal titration calorimetry, along with experimental validation, indicated that protects targeting activating the AKT (RAC serine/threonine protein kinase) signaling pathway. Pharmacological inhibition pathway or knockdown AKT1 effectively diminished protective Rk2. directly binds AKT1, facilitating its translocation from cytoplasm plasma membrane. This process markedly enhanced interaction PDPK1, promoting activation downstream signaling. Our findings demonstrate direct binding membrane translocation.

Язык: Английский

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