International Journal of Science and Research Archive,
Год журнала:
2024,
Номер
11(1), С. 2148 - 2162
Опубликована: Фев. 18, 2024
Today,
air
pollution
is
one
of
the
greatest
threats
to
organismal
healthspan.
The
environmental
earth
contaminated
with
a
wide
variety
artificially
generated
pollutants
like
fine
particulate
matter
(PM2.5)
emitting
from
industry,
fuel
engine
vehicles,
biomass
combustion,
fumes
blasting,
crop
residue
burning,
and
wildfire.
pollutant
PM2.5
induces
massive
oxidative
stress
inflammation,
major
contributors
in
initiation
progression
numerous
diseases
including
pulmonary,
cardiovascular,
renal,
hepatic,
reproductive,
neurological,
mental,
accelerated
biological
aging.
provocative
question
following:
how
can
we
solve
this
associated
problem?
As
it
not
realistic
clean
environment
at
once
toxic
pollution,
initiatives
have
been
undertaken
develop
novel
therapeutic
approaches
control
air-pollutant-induced
inflammation
devastating
diseases.
primary
goal
review
article
discuss
systematically
key
findings
recent
preclinical
studies
documenting
first,
role
augmentation
stress,
diseases;
second,
efficacies
different
natural
synthetic
compounds
amelioration
PM2.5-induced
pyroptosis,
pathologies.
Further
investigation
on
safety
these
will
be
helpful
select
effective
non-toxic
compound(s)
for
clinical
trial
drug
development.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
253, С. 114708 - 114708
Опубликована: Фев. 27, 2023
Pollution
from
fine
particulate
matter
(PM2.5)
has
become
a
major
threat
to
public
health
and
been
related
lung
toxicity.
One
of
the
key
regulators
Hippo
signaling
system,
Yes-associated
protein
1
(YAP1),
is
speculated
play
role
in
ferroptosis
development.
Here,
we
focused
on
investigating
function
YAP1
pyroptosis
ferroptosis,
aiming
explore
its
therapeutic
potential
PM2.5-induced
toxicity
was
induced
Wild-type
WT
conditional
YAP1-knockout
mice,
epithelial
cells
were
stimulatd
by
PM2.5
vitro.
We
used
western
blot,
transmission
electron
microscopy,
fluorescence
microscopy
investigate
pyroptosis-
ferroptosis-related
characteristics.
found
that
leads
using
mechanisms
involving
ferroptosis.
knockdown
impeded
pyroptosis,
damage,
as
shown
increased
histopathology,
higher
levels
proinflammatory
cytokines,
GSDMD
protein,
lipid
peroxidation,
iron
accumulation,
well
NLRP3
inflammasome
activation
decreased
SLC7A11
expression.
silencing
consistently
promoted
reduced
levels,
aggravating
cellular
damage.
In
contrast,
YAP1-overexpressing
inhibited
preventing
Overall,
our
data
suggest
ameliorates
injury
inhibiting
NLRP3-mediated
SL7A11-dependent
Frontiers in Bioscience-Landmark,
Год журнала:
2023,
Номер
28(3), С. 45 - 45
Опубликована: Март 3, 2023
Background:
Doxorubicin
(DOX)
is
an
effective
broad-spectrum
antitumor
drug,
but
its
clinical
application
limited
due
to
the
side
effects
of
cardiac
damage.
Astragaloside
IV
(AS-IV)
a
significant
active
component
Astragalus
membranaceus
that
exerts
cardioprotective
through
various
pathways.
However,
whether
AS-IV
protective
against
DOX-induced
myocardial
injury
by
regulating
pyroptosis
still
unknown
and
investigated
in
this
study.
Methods:
The
model
was
constructed
intraperitoneal
injection
DOX,
administered
via
oral
gavage
explore
specific
mechanism.
Cardiac
function
indicators,
including
lactate
dehydrogenase
(LDH),
troponin
I
(cTnI),
creatine
kinase
isoenzyme
(CK-MB),
brain
natriuretic
peptide
(BNP),
histopathology
cardiomyocytes
were
assessed
4
weeks
post
DOX
challenge.
Serum
levels
IL-1β,
IL-18,
superoxide
dismutase
(SOD),
malondialdehyde
(MDA)
glutathione
(GSH)
expression
signaling
proteins
also
determined.
Results:
dysfunction
observed
after
challenge,
as
evidenced
reduced
ejection
fraction,
increased
fibrosis,
BNP,
LDH,
cTnI,
CK-MB
(p
<
0.05,
N
=
3–10).
attenuated
injury.
mitochondrial
morphology
structure
significantly
damaged
treatment,
these
changes
restored
treatment.
induced
increase
serum
SOD,
MDA
GSH
well
pyroptosis-related
3–6).
Besides,
depressed
inflammatory-related
activation
expressions
nuclear
factor
E2-related
2
(Nrf-2)
heme
oxygenase
1
(HO-1)
3).
Conclusions:
Our
results
showed
had
effect
injury,
which
may
be
associated
with
Nrf-2/HO-1
inhibit
pyroptosis.
Phytotherapy Research,
Год журнала:
2022,
Номер
37(1), С. 195 - 210
Опубликована: Сен. 12, 2022
Inflammation
and
oxidative
stress
caused
by
fine
particulate
matter
(PM2.5)
increase
the
incidence
mortality
rates
of
respiratory
disorders.
Rosavin
is
main
chemical
component
Rhodiola
plants,
which
exerts
anti-oxidative
antiinflammatory
effects.
In
this
research,
potential
therapeutic
effect
rosavin
was
investigated
PM2.5-induced
lung
injury
rat
model.
Rats
were
instilled
with
PM2.5
(7.5
mg/kg)
suspension
intratracheally,
while
(50
mg/kg,
100
delivered
intraperitoneal
injection
before
injection.
It
observed
that
could
prevent
PM2.5.
showed
obvious
ferroptosis-related
ultrastructural
alterations,
significantly
corrected
rosavin.
The
pretreatment
downregulated
levels
tissue
iron,
malondialdehyde,
4-hydroxynonenal,
increased
glutathione.
expression
nuclear
factor
E2-related
2
(Nrf2)
upregulated
rosavin,
together
other
proteins.
RSL3,
a
specific
ferroptosis
agonist,
reversed
beneficial
impact
network
pharmacology
approach
predicted
activation
on
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(Akt)
signaling
pathway.
LY294002,
potent
PI3K
inhibitor,
decreased
upregulation
Nrf2
induced
conclusion,
prevented
stimulation
suppressed
via
upregulating
PI3K/Akt/Nrf2
Phytotherapy Research,
Год журнала:
2022,
Номер
37(3), С. 1115 - 1135
Опубликована: Дек. 23, 2022
Abstract
Caffeic
acid
phenethyl
ester
(CAPE),
a
main
active
component
of
propolis
and
flavonoid,
is
one
the
natural
products
that
has
attracted
attention
in
recent
years.
CAPE,
which
many
properties
such
as
anti‐cancer,
anti‐inflammatory,
antioxidant,
antibacterial
anti‐fungal,
shown
pharmacological
potentials,
including
protective
effects
on
multiple
organs.
Interestingly,
molecular
docking
studies
showed
possibility
binding
CAPE
with
replication
enzyme.
In
addition,
it
was
seen
order
to
increase
security
enzyme
modifications
can
be
made
at
three
sites
molecule,
leads
compound
working
more
powerfully
usefully
prevent
proliferation
cancer
cells
reduce
its
rate.
Also,
found
an
inhibitory
effect
against
protease
may
effective
treatment
SARS‐CoV‐2.
This
review
covers
detail
importance
alternative
medicine,
value,
potential
anti‐proliferative
agent,
dual
role
radioprotection
radiosensitization,
use
coronavirus
disease
2019
(COVID‐19).
