Air-pollutant particulate matter 2.5 (PM2.5)-induced inflammation and oxidative stress in diseases: Possible therapeutic approaches DOI Creative Commons
Asish K. Ghosh

International Journal of Science and Research Archive, Journal Year: 2024, Volume and Issue: 11(1), P. 2148 - 2162

Published: Feb. 18, 2024

Today, air pollution is one of the greatest threats to organismal healthspan. The environmental earth contaminated with a wide variety artificially generated pollutants like fine particulate matter (PM2.5) emitting from industry, fuel engine vehicles, biomass combustion, fumes blasting, crop residue burning, and wildfire. pollutant PM2.5 induces massive oxidative stress inflammation, major contributors in initiation progression numerous diseases including pulmonary, cardiovascular, renal, hepatic, reproductive, neurological, mental, accelerated biological aging. provocative question following: how can we solve this associated problem? As it not realistic clean environment at once toxic pollution, initiatives have been undertaken develop novel therapeutic approaches control air-pollutant-induced inflammation devastating diseases. primary goal review article discuss systematically key findings recent preclinical studies documenting first, role augmentation stress, diseases; second, efficacies different natural synthetic compounds amelioration PM2.5-induced pyroptosis, pathologies. Further investigation on safety these will be helpful select effective non-toxic compound(s) for clinical trial drug development.

Language: Английский

YAP1 protects against PM2.5-induced lung toxicity by suppressing pyroptosis and ferroptosis DOI Creative Commons
Yun Wang,

Haifeng Duan,

Jing Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 253, P. 114708 - 114708

Published: Feb. 27, 2023

Pollution from fine particulate matter (PM2.5) has become a major threat to public health and been related lung toxicity. One of the key regulators Hippo signaling system, Yes-associated protein 1 (YAP1), is speculated play role in ferroptosis development. Here, we focused on investigating function YAP1 pyroptosis ferroptosis, aiming explore its therapeutic potential PM2.5-induced toxicity was induced Wild-type WT conditional YAP1-knockout mice, epithelial cells were stimulatd by PM2.5 vitro. We used western blot, transmission electron microscopy, fluorescence microscopy investigate pyroptosis- ferroptosis-related characteristics. found that leads using mechanisms involving ferroptosis. knockdown impeded pyroptosis, damage, as shown increased histopathology, higher levels proinflammatory cytokines, GSDMD protein, lipid peroxidation, iron accumulation, well NLRP3 inflammasome activation decreased SLC7A11 expression. silencing consistently promoted reduced levels, aggravating cellular damage. In contrast, YAP1-overexpressing inhibited preventing Overall, our data suggest ameliorates injury inhibiting NLRP3-mediated SL7A11-dependent

Language: Английский

Citations

21
Astragaloside IV Inhibits NLRP3 Inflammasome-Mediated Pyroptosis via Activation of Nrf-2/HO-1 Signaling Pathway and Protects against Doxorubicin-Induced Cardiac Dysfunction DOI Creative Commons

Xueheng Chen,

Chao Tian, Zhiqiang Zhang

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(3), P. 45 - 45

Published: March 3, 2023

Background: Doxorubicin (DOX) is an effective broad-spectrum antitumor drug, but its clinical application limited due to the side effects of cardiac damage. Astragaloside IV (AS-IV) a significant active component Astragalus membranaceus that exerts cardioprotective through various pathways. However, whether AS-IV protective against DOX-induced myocardial injury by regulating pyroptosis still unknown and investigated in this study. Methods: The model was constructed intraperitoneal injection DOX, administered via oral gavage explore specific mechanism. Cardiac function indicators, including lactate dehydrogenase (LDH), troponin I (cTnI), creatine kinase isoenzyme (CK-MB), brain natriuretic peptide (BNP), histopathology cardiomyocytes were assessed 4 weeks post DOX challenge. Serum levels IL-1β, IL-18, superoxide dismutase (SOD), malondialdehyde (MDA) glutathione (GSH) expression signaling proteins also determined. Results: dysfunction observed after challenge, as evidenced reduced ejection fraction, increased fibrosis, BNP, LDH, cTnI, CK-MB (p < 0.05, N = 3–10). attenuated injury. mitochondrial morphology structure significantly damaged treatment, these changes restored treatment. induced increase serum SOD, MDA GSH well pyroptosis-related 3–6). Besides, depressed inflammatory-related activation expressions nuclear factor E2-related 2 (Nrf-2) heme oxygenase 1 (HO-1) 3). Conclusions: Our results showed had effect injury, which may be associated with Nrf-2/HO-1 inhibit pyroptosis.

Language: Английский

Citations

21
Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome DOI
Shihua Shi, Demei Huang, Yongcan Wu

et al.

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 177, P. 113858 - 113858

Published: May 24, 2023

Language: Английский

Citations

18
Pretreatment with rosavin attenuates PM2.5‐induced lung injury in rats through antiferroptosis via PI3K/Akt/Nrf2 signaling pathway DOI
Yilan Wang, Sijing Zhao,

Nan Jia

et al.

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 37(1), P. 195 - 210

Published: Sept. 12, 2022

Inflammation and oxidative stress caused by fine particulate matter (PM2.5) increase the incidence mortality rates of respiratory disorders. Rosavin is main chemical component Rhodiola plants, which exerts anti-oxidative antiinflammatory effects. In this research, potential therapeutic effect rosavin was investigated PM2.5-induced lung injury rat model. Rats were instilled with PM2.5 (7.5 mg/kg) suspension intratracheally, while (50 mg/kg, 100 delivered intraperitoneal injection before injection. It observed that could prevent PM2.5. showed obvious ferroptosis-related ultrastructural alterations, significantly corrected rosavin. The pretreatment downregulated levels tissue iron, malondialdehyde, 4-hydroxynonenal, increased glutathione. expression nuclear factor E2-related 2 (Nrf2) upregulated rosavin, together other proteins. RSL3, a specific ferroptosis agonist, reversed beneficial impact network pharmacology approach predicted activation on phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. LY294002, potent PI3K inhibitor, decreased upregulation Nrf2 induced conclusion, prevented stimulation suppressed via upregulating PI3K/Akt/Nrf2

Language: Английский

Citations

23
Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway DOI
Demei Huang, Zherui Shen, Sijing Zhao

et al.

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 376, P. 110448 - 110448

Published: March 9, 2023

Language: Английский

Citations

13
Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway DOI
Li Liu,

Qiangqiang Shi,

Kankai Wang

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 113, P. 109398 - 109398

Published: Nov. 4, 2022

Language: Английский

Citations

19
Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury DOI Creative Commons
Qi Shao, Yan D. Zhao, Yaohong Shi

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117702 - 117702

Published: Jan. 1, 2025

Language: Английский

Citations

0
Fudosteine attenuates lung inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting pyroptosis via the NLRP3/caspase-1/GSDMD pathway DOI
Jianling Liu, Zhongpeng Li, Zhongyi Li

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117346 - 117346

Published: April 1, 2025

Language: Английский

Citations

0
Electroacupuncture alleviates diesel exhaust particles-induced inflammatory response in lung through dopamine inhibition of NLRP3 signaling pathway DOI

Yuanting Xie,

Jing Han, Qianfeng Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118184 - 118184

Published: April 14, 2025

Language: Английский

Citations

0
Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy DOI
Seyithan Taysı, Firas Shawqi Algburi, Muhammed Enes Taysi

et al.

Phytotherapy Research, Journal Year: 2022, Volume and Issue: 37(3), P. 1115 - 1135

Published: Dec. 23, 2022

Abstract Caffeic acid phenethyl ester (CAPE), a main active component of propolis and flavonoid, is one the natural products that has attracted attention in recent years. CAPE, which many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial anti‐fungal, shown pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed possibility binding CAPE with replication enzyme. In addition, it was seen order to increase security enzyme modifications can be made at three sites molecule, leads compound working more powerfully usefully prevent proliferation cancer cells reduce its rate. Also, found an inhibitory effect against protease may effective treatment SARS‐CoV‐2. This review covers detail importance alternative medicine, value, potential anti‐proliferative agent, dual role radioprotection radiosensitization, use coronavirus disease 2019 (COVID‐19).

Language: Английский

Citations

16