Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Cell Biochemistry and Function, Год журнала: 2024, Номер 42(1)

Опубликована: Янв. 1, 2024

Abstract Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness limited due to poor absorption rapid elimination the body. Various curcumin derivatives have also shown anticancer potential in‐vitro in‐vivo models. multiple signaling pathways development/progression or induce cell death through apoptosis. In addition, could enhance of conventional chemotherapy, radiation therapy reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored overcome challenges with curcumin's delivery, increasing overall efficacy. The use an imaging system track these formulations give beneficial information about bioavailability distribution nano‐curcumin complex. conclusion, holds significant promise fight against cancer, especially nanoform, provide precise cells without affecting normal healthy cells.

Язык: Английский

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An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB regulates a wide range physiological processes, such as survival, growth, migration. Deregulated NF-kB resulted in unregulated proliferation, viability, movement, invasion, thus promoting tumor development. Recent findings have increasingly shown that plant derived phytochemicals inhibit potential to be employed cancer therapeutics. Flavonoids are group polyphenolic natural compounds present various plants their fruits, vegetables, leaves. These medicinal properties owing antioxidant, anti-inflammatory, antiviral, antitumor characteristics. The main mechanism by which these flavonoids exhibit anticancer via potent antioxidative immunomodulatory actions. Current research reports demonstrated exhibited effects suppressing signaling. Based on facts, we comprehensively outlined role processes progression, drug resistance, angiogenesis metastasis. In addition these, also summarize specifically targeting types cancers.

Язык: Английский

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The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer

Cells, Год журнала: 2022, Номер 11(14), С. 2209 - 2209

Опубликована: Июль 15, 2022

Natural products play a critical role in the discovery and development of numerous drugs for treatment various types cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with initiation, development, progression cancer through altering mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, metastasis. Treating multifactorial diseases, agents targeting single target, might lead to limited success and, many cases, unsatisfactory outcomes. Various epidemiological studies shown that steady consumption fruits vegetables is intensely associated reduced risk Since ancient period, plants, herbs, other natural been used healing agents. Likewise, most medicinal ingredients accessible today are originated from resources. Regardless achievements, developing bioactive compounds has remained challenging, part because problem large-scale sequestration mechanistic understanding. With significant progress landscape therapy rising use cutting-edge technologies, we may come crossroads review approaches identify potential investigate their therapeutic efficacy. In present review, summarize recent developments products-based research its application generating novel systemic strategies focus on underlying molecular solid

Язык: Английский

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Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways

Molecules, Год журнала: 2022, Номер 27(13), С. 4304 - 4304

Опубликована: Июль 4, 2022

Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases many mammalian bodies promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities numerous properties due to which it has been considered as traditional medicine for decades. shows synergistic effects combined treatment sorafenib HepG2 human cell line (HCC) less time statistically reduces viability cells, migration, gene expression apoptosis. The combination anti-cancerous drugs apigenin shown health promoting against various cancers. It can prevent mobility, maintain cycle stimulate immune system. also suppresses mTOR activity raises UVB-induced phagocytosis cancerous proliferation growth. high safety threshold, active (anti-cancer) doses be gained by consuming vegetable rich diet. boosted autophagosome formation, decreased activated autophagy preventing PI3K pathway, specifically cells. This paper provides an updated overview apigenin's beneficial anti-inflammatory, antibacterial, antiviral, anticancer effects, making step right direction therapeutics. study critically analyzed effect on cancer signaling pathways including PI3K/AKT/MTOR, JAK/STAT, NF-κB ERK/MAPK pathways.

Язык: Английский

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Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

Antioxidants, Год журнала: 2023, Номер 12(3), С. 586 - 586

Опубликована: Фев. 27, 2023

Citrus (genus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic divided into subclasses, in which flavanones the most prominent. Among them, naringenin and hesperidin emerging anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including modulation epigenetics, estrogen signaling, induction cell death via regulation apoptotic signaling pathways, inhibition tumor invasion metastasis. However, this information is sparse literature needs to be brought together provide an overview how can serve therapeutic tools drug development a successful co-adjuvant strategy against BC. This review detailed context highlighted could interfere BC carcinogenesis helpful potential alternative treatment.

Язык: Английский

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Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Chemistry & Biodiversity, Год журнала: 2023, Номер 20(9)

Опубликована: Авг. 7, 2023

With the increasing prevalence of cancer and toxic side effects synthetic drugs, natural products are being developed as promising therapeutic approaches. Gracillin is a naturally occurring triterpenoid steroidal saponin with several activities. It obtained major compound from different Dioscorea species. This review was designated to summarize research progress on anti-cancer activities gracillin focusing underlying cellular molecular mechanisms, well its pharmacokinetic features. The data were collected (up date May 1, 2023) various reliable authentic literatures comprising PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. findings demonstrated that displays anticancer through including anti-inflammatory effects, apoptotic cell death, induction oxidative stress, cytotoxicity, genotoxicity, cycle arrest, anti-proliferative effect, autophagy, inhibition glycolysis, blocking migration. Additionally, this highlighted features gracillin, indicating lower oral bioavailability. As conclusion, it can be proposed could serve hopeful chemotherapeutic agent. However, further extensive clinical recommended establish safety, efficacy, potential in treatment.

Язык: Английский

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Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

Journal of Functional Foods, Год журнала: 2023, Номер 104, С. 105502 - 105502

Опубликована: Март 21, 2023

Cancer is identified as second leading causes of death and imposes a significant psychological economic burden on societies. Due to its high prevalence, main cause worldwide, there continuing need discover new potential anticancer compounds. Plant-derived compounds have recently attracted more attention among researchers for their potent anti-cancer properties. A numerous research, including in-vitro, in-vivo, preclinical, clinical, epidemiological studies, has indicated that the flavonoid silymarin comprehensive preventive therapeutic effects array inflammation-driven diseases, cancer. Silymarin clear activities through distinctive mechanisms modulation apoptosis in-vitro survival in-vivo. The chemoprotection constituent suggest they could be promising agents in various cancer types. This review focus vivo vitro variety cancers, explores signaling pathways modulated by this compound.

Язык: Английский

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Recent Update and Drug Target in Molecular and Pharmacological Insights into Autophagy Modulation in Cancer Treatment and Future Progress

Cells, Год журнала: 2023, Номер 12(3), С. 458 - 458

Опубликована: Янв. 31, 2023

Recent evidence suggests that autophagy is a governed catabolic framework enabling the recycling of nutrients from injured organelles and other cellular constituents via lysosomal breakdown. This mechanism has been associated with development various pathologic conditions, including cancer neurological disorders; however, recently updated studies have indicated plays dual role in cancer, acting as cytoprotective or cytotoxic mechanism. Numerous preclinical clinical investigations shown inhibiting enhances an anticancer medicine’s effectiveness malignancies. Autophagy antagonists, chloroquine hydroxychloroquine, previously authorized trials, encouraging medication-combination therapies targeting autophagic processes for cancer. In this review, we provide update on recent research examining efficacy combining drugs activate inhibitors. Additionally, highlight difficulties progress toward using treatment strategy. Importantly, must enable use suitable inhibitors coadministration delivery systems conjunction agents. Therefore, review briefly summarizes general molecular process behind its bifunctional important suppression tumor growth resistance to chemotherapy metastasis regulation. We then emphasize how cells interacting one another promising therapeutic target treatment.

Язык: Английский

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Reactive oxygen species mediated apoptotic death of colon cancer cells: therapeutic potential of plant derived alkaloids

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июль 25, 2023

Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk factors including hormones like insulin and growth (e.g., IGF-1) have been considered responsible for progression colon cancer. Though there a huge advancement in available screening as well treatment techniques CRC. There no significant decrease mortality patients. Moreover, current approaches CRC are associated with serious challenges drug resistance re-growth. Given severity disease, an urgent need novel therapeutic agents ideal characteristics. pieces evidence suggested that natural products, specifically medicinal plants, derived phytochemicals may serve potential sources discovery various On other hand, cells require high basal level reactive oxygen species (ROS) to maintain its own cellular functions. However, excess production intracellular ROS leads cell death via disturbing redox homeostasis. Therefore, plants phytocompounds can enhance induce apoptotic modulating molecular targets IGF-1 could be agents. Alkaloids form major class such phytoconstituents play key role prevention. several preclinical clinical studies also evidenced these compounds show potent anti-colon effects exhibit negligible toxicity towards normal cells. Hence, present evidence-based study aimed provide update on alkaloids reported ROS-mediated apoptosis targeting components factors, which metastasis, angiogenesis, proliferation, invasion. This provides individual account each alkaloid underwent trials either alone or combination drugs. In addition, classes different kinds cancers discussed.

Язык: Английский

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A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Сен. 25, 2023

Leonurine refers to the desiccated aerial portion of a plant in Labiatae family. The primary bioactive constituent is an alkaloid, alkaloid (Leo), renowned for its substantial therapeutic efficacy treatment gynecological disorders, addition broad-spectrum antineoplastic capabilities. Over recent years, pharmacodynamic mechanisms Leo have garnered escalating scholarly interest. exhibits anticancer potential by means array mechanisms, encompassing inhibition neoplastic cell proliferation, induction both apoptosis and autophagy, containment oncogenic invasion migration. key signal transduction pathways implicated these processes include Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), Phosphoinositide3-Kinase/Serine/Threonine Protein Kinase (PI3K/AKT), Signal Transducer Activator Transcription 3 (STAT3), Mitogen-Activated Protein/Extracellular Signal-Regulated (MAP/ERK). This paper commences with exploration principal cellular behaviors influenced associated pathways, thereby scrutinizing sequence events. intention offer theoretical reinforcement elucidation more profound underpinning Leo's correlating pharmaceutical development.

Язык: Английский

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