Biotechnology and Applied Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
ABSTRACT
This
study
emphasizes
to
investigate
the
modulatory
activity
of
trans
‐ferulic
acid
(TFA)
on
anti‐inflammatory
etoricoxib
(ETO)
and
underlying
mechanisms
via
formalin‐induced
licking
paw
edema
model
in
silico
study.
Inflammation
was
induced
by
injecting
formalin
(50
µL)
into
right
hind
mice.
The
animals
were
treated
with
different
doses
TFA
(25,
50,
75
mg/kg,
p.o.).
vehicle
ETO
(35
p.o.)
provided
as
positive
negative
control,
respectively.
also
served
combined
evaluate
activity.
behavior
counted
for
early
late
phases,
whereas
diameter
measured
using
a
slide
caliper.
All
treatment
continued
7
days
until
totally
minimized
determine
inflammation's
recovery
capability
specific
group.
Different
computed
web
tools
used
estimate
molecular
binding
affinity,
interactions,
pharmacokinetics.
findings
demonstrated
that
significantly
(p
<
0.05)
enhanced
onset
reduced
number
licks
compared
showed
significant
diminished
complete
recovered
after
5
indicating
effects.
However,
notably
effects
enhancing
number.
expressed
elevated
affinity
−7.5
−6.5
kcal/mol
toward
nitric
oxide
(NO)
synthase
COX‐1,
In
conclusion,
exerted
reduces
ETO.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 19, 2024
Abstract
The
present
study
was
designed
to
evaluate
the
antiemetic
activity
of
abietic
acid
(AA)
using
in
vivo
and
silico
studies.
To
assess
effect,
doses
50
mg/kg
b.w.
copper
sulfate
(CuSO
4
⋅5H
2
O)
were
given
orally
2-day-old
chicks.
test
compound
at
two
20
40
On
other
hand,
aprepitant
(16
mg/kg),
domperidone
(6
diphenhydramine
(10
hyoscine
(21
ondansetron
(5
mg/kg)
administered
as
positive
controls
(PCs).
vehicle
used
a
control
group.
Combination
therapies
with
referral
drugs
also
three
separate
groups
animals
see
synergistic
antagonizing
compound.
Molecular
docking
visualization
ligand-receptor
interaction
performed
different
computational
tools
against
various
emesis-inducing
receptors
(D
,
D
3
5HT
H
1
M
–M
5
).
Furthermore,
pharmacokinetics
toxicity
properties
selected
ligands
predicted
by
SwissADME
Protox-II
online
servers.
Findings
indicated
that
AA
dose-dependently
enhances
latency
emetic
retching
reduces
number
compared
Among
treatments,
treated
(40
exhibited
highest
(98
±
2.44
s)
reduced
(11.66
2.52
times)
groups.
Additionally,
molecular
exhibits
binding
affinity
(−
10.2
kcal/mol)
toward
an
elevated
8.1
kcal/mol),
7.7
8.7
8.5
than
ligands.
Taken
together,
our
suggests
has
potent
effects
interacting
5TH
muscarinic
receptor
pathways.
However,
additional
extensive
pre-clinical
clinical
studies
are
required
efficacy
AA.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(9), С. 1271 - 1271
Опубликована: Сен. 7, 2023
Numerous
previous
studies
reported
that
ferulic
acid
exerts
anxiolytic
activity.
However,
the
mechanisms
have
yet
to
be
elucidated.
The
current
study
aimed
investigate
effect
of
trans-ferulic
(TFA),
a
stereoisomer
acid,
and
evaluated
its
underlying
mechanism
using
in
vivo
computational
studies.
For
this,
different
experimental
doses
TFA
(25,
50,
75
mg/kg)
were
administered
orally
Swiss
albino
mice,
various
behavioral
methods
open
field,
hole
board,
swing
box,
light-dark
tests
carried
out.
Diazepam
(DZP),
positive
allosteric
modulator
GABAA
receptor,
was
employed
as
control
at
dose
2
mg/kg,
distilled
water
served
vehicle.
Additionally,
molecular
docking
performed
estimate
binding
affinities
DZP
toward
receptor
subunits
α2
α3,
which
are
associated
with
effect;
visualizations
ligand-receptor
interaction
out
tools.
Our
findings
indicate
dose-dependently
reduces
locomotor
activity
animals
comparison
controls,
calming
their
behaviors.
In
addition,
exerted
highest
affinity
(-5.8
kcal/mol)
subunit
by
forming
several
hydrogen
hydrophobic
bonds.
Taken
together,
our
suggest
similar
DZP,
compound
moderate
through
GABAergic
pathway.
We
further
clinical
develop
reliable
agent.
Molecules,
Год журнала:
2023,
Номер
28(16), С. 6141 - 6141
Опубликована: Авг. 19, 2023
Fruits
and
vegetables
are
used
not
only
for
nutritional
purposes
but
also
as
therapeutics
to
treat
various
diseases
ailments.
These
food
items
prominent
sources
of
phytochemicals
that
exhibit
chemopreventive
therapeutic
effects
against
several
diseases.
Hirsutine
(HSN)
is
a
naturally
occurring
indole
alkaloid
found
in
Uncaria
species
has
multitude
benefits.
It
foodstuffs
such
fish,
seafood,
meat,
poultry,
dairy,
some
grain
products
among
other
things.
In
addition,
it
present
fruits
including
corn,
cauliflower,
mushrooms,
potatoes,
bamboo
shoots,
bananas,
cantaloupe,
citrus
fruits.
The
primary
emphasis
this
study
summarize
the
pharmacological
activities
underlying
mechanisms
HSN
different
diseases,
well
biopharmaceutical
features.
For
this,
data
were
collected
(up
date
1
July
2023)
from
reliable
authentic
literature
by
searching
academic
search
engines,
PubMed,
Springer
Link,
Scopus,
Wiley
Online,
Web
Science,
ScienceDirect,
Google
Scholar.
Findings
indicated
exerts
preclinical
experimental
systems.
exhibits
anti-inflammatory,
antiviral,
anti-diabetic,
antioxidant
with
beneficial
neurological
cardiovascular
Our
findings
indicate
promising
anticancer
potentials
via
molecular
mechanisms,
apoptotic
cell
death,
induction
oxidative
stress,
cytotoxic
effect,
anti-proliferative
genotoxic
inhibition
cancer
migration
invasion
cancers
lung,
breast,
antitumor
human
T-cell
leukemia.
Taken
all
together,
show
can
be
agent
cancer.
Heliyon,
Год журнала:
2024,
Номер
10(12), С. e32899 - e32899
Опубликована: Июнь 1, 2024
Natural
products
are
being
developed
as
possible
treatment
options
due
to
the
rising
prevalence
of
cancer
and
harmful
side
effects
synthetic
medications.
Arctiin
is
a
naturally
occurring
lignan
found
in
numerous
plants
exhibits
different
pharmacological
activities,
along
with
cancer.
To
elucidate
anticancer
properties
underlying
mechanisms
action,
comprehensive
search
various
electronic
databases
was
conducted
using
appropriate
keywords
identify
relevant
publications.
The
findings
suggest
that
arctiin
against
tumor
formation
cancers
such
cervical,
myeloma,
prostate,
endothelial,
gastric,
colon
several
preclinical
investigations.
This
compound
exerts
its
effect
through
cellular
mechanisms,
including
mitochondrial
dysfunction,
cell
cycle
at
phases
(G2/M),
inhibition
proliferation,
apoptotic
death,
cytotoxic
effects,
well
migration
invasion
malignant
cells.
Moreover,
study
also
revealed
that,
among
pathways,
shown
be
more
potent
terms
PI3K/AKT
JAK/STAT
signaling
pathways.
However,
pharmacokinetic
investigation
indicated
compound's
poor
oral
bioavailability.
Because
these
findings,
might
considered
promising
chemotherapeutic
drug
candidate.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 8, 2024
Abstract
This
study
evaluates
the
pharmacological
effects
of
iridoid
glucoside
loganic
acid,
a
plant
constituent
with
diverse
properties,
based
on
literature,
and
explores
underlying
cellular
mechanisms
for
treating
several
ailments.
Data
were
collected
from
reliable
electronic
databases,
including
PubMed,
Scopus,
Web
Science,
Google
Scholar,
etc.
The
results
demonstrated
anti‐inflammatory,
anti‐oxidant,
other
protective
acid
metabolic
diseases
disorders
such
as
atherosclerosis,
diabetes,
obesity,
in
addition
to
its
osteoprotective
anticancer
properties.
antioxidant
activity
demonstrates
capacity
protect
cells
oxidative
damage
mitigates
inflammation
by
reducing
inflammatory
cytokines
involving
TNF‐α
IL‐6,
substantially
upregulating
expression
PPAR‐γ/α,
decreasing
clinical
signs
inflammation‐related
conditions
related
hypertriglyceridemia
atherosclerosis.
Meanwhile,
inhibits
bone
loss,
exhibits
properties
increasing
mRNA
levels
synthesizing
genes
Alpl,
Bglap,
Sp7,
significantly
increases
osteoblastic
proliferation
preosteoblast
cells.
Loganic
is
an
anti‐metastatic
drug
that
reduces
MnSOD
expression,
EMT
metastasis,
prevents
migration,
proliferation,
invasion
hepatocellular
carcinoma
However,
additional
trials
are
required
assess
safety,
efficacy,
human
dose.
Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Апрель 16, 2024
Gigantol,
a
bibenzyl
compound
extracted
from
various
medicinal
plants,
has
shown
number
of
biological
activities,
making
it
an
attractive
candidate
for
potential
medical
applications.
This
systematic
review
aims
to
shed
light
on
gigantol's
promising
role
in
inflammation
treatment
and
its
underlying
mechanisms.
Gigantol
exhibits
anti-inflammatory
properties
pre-clinical
pharmacological
test
systems.
It
effectively
reduced
the
levels
pro-inflammatory
markers
arachidonic
acid
metabolites
through
pathways,
such
as
NF-κB,
AKT,
PI3K,
JNK/cPLA2/12-LOX.
The
in-silico
investigations
demonstrated
that
MMP-13
enzyme
served
most
target
gigantol
with
highest
binding
affinity
(docking
score
=
−8.8
kcal/mol).
Encouragingly,
absorption,
distribution,
metabolism,
excretion,
toxicity
(ADMET)
analysis
confirmed
compatibility
necessary
physiochemical,
pharmacokinetic,
properties,
bolstering
drug
candidate.
well-documented
could
be
agent
treating
near
future.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 16, 2024
Introduction:
D-pinitol,
a
naturally
occurring
inositol,
has
diverse
biological
activities
like
antioxidant,
antimicrobial
and
anticancer
activities.
This
study
aimed
to
evaluate
anti-inflammatory
effect
of
d-pinitol
in
chick
model.
Additionally,
silico
studies
were
performed
the
molecular
interactions
with
cyclooxygenase-2
(COX-2).
Methods:
The
tested
groups
received
(12.5,
25,
50
mg/kg)
standard
drugs
celecoxib
ketoprofen
(42
via
oral
gavage
prior
formalin
injection.
Then,
number
licks
was
counted
for
first
10
min,
paw
edema
diameter
measured
at
60,
90,
120
min.
Results
Discussion:
significantly
(
p
<
0.05)
reduced
diameters,
compared
negative
control.
When
combined
celecoxib,
it
inflammatory
parameters
more
effectively
than
individual
groups.
showed
promising
binding
capacity
COX-2.
Taken
together,
exerted
effects
dose-dependent
manner,
possibly
through
COX-2
interaction
pathway.
