Nutrients, Год журнала: 2024, Номер 16(20), С. 3432 - 3432
Опубликована: Окт. 10, 2024
The link between diet and immune function is a growing area of interest, recognized not only by the scientific community but also global health organizations, such as World Health Organization (WHO) [...].
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 241, С. 124386 - 124386
Опубликована: Апрель 11, 2023
Язык: Английский
Процитировано
84
Communications Biology, Год журнала: 2023, Номер 6(1)
Опубликована: Сен. 1, 2023
Abstract Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant been a great task. Transcriptome-wide (TWAS) is an instrumental post-analysis to detect gene-trait associations focusing on modeling transcription-level regulations, which made numerous progresses in recent years. Leveraging from expression quantitative loci (eQTL) regulation information, TWAS advantages detecting functioning regulated by disease-associated variants, thus providing insight into mechanisms of diseases and other phenotypes. Considering its vast potential, this review article comprehensively summarizes TWAS, including the methodology, applications available resources.
Язык: Английский
Процитировано
55
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(14), С. 7694 - 7694
Опубликована: Июль 12, 2022
Mulberry (Morus alba L.) is a flowering tree traditionally used in Chinese herbal medicine. leaf flavonoids (MLFs) have been reported to exert important anti-inflammatory and antioxidant properties. The purpose of this study was select the MLF with best antioxidative activities from MLFs eluted by different ethanol concentrations (30%, 50%, 75%) explore its pharmacological Three types inhibited production nitric oxide (NO), prostaglandin E2 (PGE2), inducible synthase (iNOS), cyclooxygenase-2 (COX-2), inflammatory cytokines lipopolysaccharide (LPS)-induced RAW 264.7 cells. All boosted capacity decreasing reactive oxygen species (ROS) scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals improving metal ion chelating activity reducing power. results revealed that 30% exhibited activities. A nontargeted metabolomic analysis analyze 24 differential between MLFs. Quercetin, kaempferol, their derivatives 30%MLF were more abundant than other two Furthermore, we evaluated dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) mice. could alleviate clinical symptoms, reduce secretion cytokines, inhibit activation pathway DSS-induced This will provide valuable information for development as functional food.
Язык: Английский
Процитировано
39
Food Chemistry, Год журнала: 2024, Номер 462, С. 140951 - 140951
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
11
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138633 - 138633
Опубликована: Дек. 13, 2024
Язык: Английский
Процитировано
9
Natural Products and Bioprospecting, Год журнала: 2024, Номер 14(1)
Опубликована: Июль 30, 2024
Abstract Ulcerative colitis (UC) is a recurring autoimmune disorder characterized by persistent inflammation in the mucosal lining of lower part large intestine. Conventional treatment options such as salicylates, corticosteroids, and immunosuppressants often come with severe side effects, limited bioavailability, development drug resistance, which hampers their therapeutic effectiveness. Therefore, it imperative to explore natural strategies safe alternative treatments for UC. Currently, around 40% UC patients find relief through constituents, can help reduce toxic effects maintain clinical remission. This review aims provide summary both preclinical evidence supporting efficacy various substances prophylaxis These include plant extracts, essential oils, nutraceuticals, phytochemicals. Furthermore, we will delve into potential mechanisms that underlie protective curative actions these novel herbal agents. In summary, this effectiveness remedies UC, shedding light on findings behind actions. alternatives offer hope improved outcomes reduced individuals suffering from challenging condition. Graphical
Язык: Английский
Процитировано
6
Antioxidants, Год журнала: 2023, Номер 12(10), С. 1867 - 1867
Опубликована: Окт. 16, 2023
N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine, has been widely used as a mucolytic agent and antidote for acetaminophen overdose since 1960s 1980s, respectively. NAC possesses antioxidant, cytoprotective, anti-inflammatory, antimicrobial, properties, making it promising therapeutic wide range diseases in both humans domesticated animals. Oxidative stress inflammation play major role onset progression all these diseases. NAC's primary is to replenish glutathione (GSH) stores, master antioxidant tissues; however, can also reduce levels pro-inflammatory tumor necrosis factor-alpha (TNF-∝) interleukins (IL-6 IL-1β), inhibit formation microbial biofilms destroy biofilms, break down disulfide bonds between mucin molecules. Many experimental studies have conducted on use address pathological conditions; its effectiveness clinical trials remains limited often conflicting results. The purpose this review provide concise overview usages treatment different human domestic animal disorders.
Язык: Английский
Процитировано
15
Designed Monomers & Polymers, Год журнала: 2024, Номер 28(1), С. 1 - 34
Опубликована: Дек. 31, 2024
This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.
Язык: Английский
Процитировано
5
Biologics, Год журнала: 2025, Номер 5(1), С. 2 - 2
Опубликована: Янв. 14, 2025
Background/Objectives: Perilla frutescens has historically been used to protect against inflammation and redox stress. This partly attributed its high polyphenolic content; however, components in extract remain incompletely defined. study aimed characterise the composition evaluate effect on transcription factor nuclear erythroid 2-related 2 (Nrf2), regulating antioxidant defenses during oxidative Methods: Hot water extraction from leaves was followed by fractionation using four solvents of different polarity, namely methanol, butanol, ethyl acetate ether. The these fractions analysed RP-HPLC, some compounds were quantified. total phenolic, flavonoid, ortho-diphenolic contents each fraction determined. activity assessed metal cation reduction radical scavenging assays. A dual-luciferase assay a human NQO1 ARE-luciferase reporter plasmid employed quantify Nrf2 activation fractions. Results: HPLC analysis identified 35 compounds, with highest phenolic content present polar rosmarinic acid being major constituent. Radical tests (DPPH ABTS) confirmed capacity On cells vitro, methanol displayed strongest activity, showing up 1.5-fold increase induction. Conclusions: shown that contains diversity contributing potent effects, butanol most efficient solvents. While is expected be contributor towards providing protection stress, further work required synergystic effects between polyphenols.
Язык: Английский
Процитировано
0
BioNanoScience, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0