Natural products and derivatives for breast cancer treatment: From drug discovery to molecular mechanism

Phytomedicine, Год журнала: 2024, Номер 129, С. 155600 - 155600

Опубликована: Апрель 7, 2024

Breast cancer stands as the most common malignancy among women globally and a leading cause of cancer-related mortality. Conventional treatments, such surgery, hormone therapy, radiotherapy, chemotherapy, small-molecule targeted often fall short addressing complexity heterogeneity certain breast subtypes, to drug resistance metastatic progression. Thus, search for novel therapeutic targets agents is imperative. Given their low toxicity abundant variety, natural products derivatives are increasingly considered valuable sources anticancer drugs. This review aims elucidate pharmacological impacts underlying mechanisms active compounds found in select derivatives, primarily focusing on treatment. It intends underscore potential these substances combating guide future research directions development product-based therapeutics. We conducted comprehensive searches electronic databases PubMed, Web Science, Scopus until October 2023, using keywords 'breast cancer', 'natural products', 'derivatives', 'mechanism', 'signaling pathways', various keyword combinations. The presents spectrum phytochemicals, including but not limited flavonoids, polyphenols, alkaloids, examines actions animal cellular models cancer. effects manifested through diverse mechanisms, induction cell death via apoptosis autophagy, suppression tumor angiogenesis. An increasing array proving effective against Future strategies can benefit from strategic enhancement properties compounds, optimization action, improved bioavailability, minimized side effects. forthcoming should prioritize facets maximize

Язык: Английский

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HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response

Pharmacological Research, Год журнала: 2023, Номер 190, С. 106732 - 106732

Опубликована: Март 15, 2023

High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in nucleus. Importantly, aberrant expression HMGA2 occurs during carcinogenesis, and this an upstream mediator cancer hallmarks including evasion apoptosis, proliferation, invasion, metastasis, therapy resistance. targets critical signaling pathways such as Wnt/β-catenin mTOR cells. Therefore, suppression function notably decreases progression improves outcome patients. As mainly oncogenic, targeting by non-coding RNAs (ncRNAs) crucial to take into consideration since it affects function. MicroRNAs (miRNAs) belong ncRNAs are master regulators vital cell processes, which affect all aspects hallmarks. Long (lncRNAs) circular (circRNAs), other members ncRNAs, mediators miRNAs. The current review intends discuss importance miRNA/HMGA2 axis modulation various types cancer, mentions lncRNAs circRNAs, regulate mediators. Finally, we effect miRNAs interactions on response cells therapy. Regarding role regulation cells, considering confirmed interaction between one miRNAs, promising could be subject future clinical trial experiments.

Язык: Английский

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GAS5 lncRNA: A biomarker and therapeutic target in breast cancer

Pathology - Research and Practice, Год журнала: 2024, Номер 260, С. 155424 - 155424

Опубликована: Июнь 20, 2024

Язык: Английский

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Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice

Phytomedicine, Год журнала: 2024, Номер 128, С. 155418 - 155418

Опубликована: Фев. 9, 2024

Язык: Английский

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Cisplatin-based combination therapies: Their efficacy with a focus on ginsenosides co-administration

Pharmacological Research, Год журнала: 2024, Номер 203, С. 107175 - 107175

Опубликована: Апрель 4, 2024

Cisplatin, a frequently prescribed chemotherapeutic agent, serves as clinically therapeutic strategy for broad range of malignancies. Its primary mode action centers around interference with DNA replication and RNA transcription, thereby inducing apoptosis in cancer cells. Nevertheless, the clinical utility cisplatin is constrained by its severe adverse effects burgeoning problem drug resistance. Ginsenosides, potent bioactive constituents derived from ginseng, possess an array biological activities. Recent scientific investigations underscore substantial amplification cisplatin's anticancer potency mitigation harmful side when administered concomitantly ginsenosides. This review aims to explore underlying mechanisms at play this combination therapy. Initially, we provide concise introduction cisplatin. Then, pivot towards illuminating how ginsenosides bolster efficacy counteract resistance, culminating enhanced outcomes. Furthermore, extensive discussion on reduction cisplatin-induced toxicity kidneys, liver, gastrointestinal tract, nervous system, ear, accompanied immune-fortification The existing combined use also discussed. We propose several recommendations propel additional research into governing synergistic cisplatin, furnishing invaluable insights fostering advancement modality

Язык: Английский

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EZH2: The roles in targeted therapy and mechanisms of resistance in breast cancer

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116624 - 116624

Опубликована: Апрель 25, 2024

Drug resistance presents a formidable challenge in the realm of breast cancer therapy. Accumulating evidence suggests that enhancer zeste homolog 2 (EZH2), component polycomb repressive complex (PRC2), may serve as key regulator controlling drug resistance. EZH2 overexpression has been observed and many other malignancies, showing strong correlation with poor outcomes. This review aims to summarize mechanisms by which regulates resistance, specific focus on cancer, order provide comprehensive understanding underlying molecular processes. Additionally, we will discuss current strategies outcomes targeting using both single agents combination therapies, goal offering improved guidance for clinical treatment patients who have developed

Язык: Английский

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Liquid biopsy technologies: innovations and future directions in breast cancer biomarker detection

Biomedical Microdevices, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 24, 2025

Язык: Английский

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Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 161, С. 114546 - 114546

Опубликована: Март 21, 2023

As a devastating disease, breast cancer has been responsible for decrease in life expectancy of females and its morbidity mortality are high. Breast is the most common tumor treatment based on employment surgical resection, chemotherapy radiotherapy. The changes biological behavior relies genomic epigenetic mutations depletions as well dysregulation molecular mechanisms that autophagy among them. Autophagy function can be oncogenic increasing tumorigenesis, when it pro-death function, causes reduction viability cells. carcinogenic an impediment towards effective therapy patients, cause drug resistance radio-resistance. important hallmarks such glucose metabolism, proliferation, apoptosis metastasis regulated by autophagy. Oncogenic inhibit apoptosis, while promotes stemness tumor. Moreover, demonstrates interaction with microenvironment components macrophages level anti-tumor compounds therapy. reasons considering pleiotropic dual role (pro-survival pro-death) crosstalk apoptosis. current review provides pre-clinical clinical evaluation

Язык: Английский

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Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition

Cellular Oncology, Год журнала: 2023, Номер 46(6), С. 1791 - 1806

Опубликована: Авг. 30, 2023

Язык: Английский

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Novel Implication of the Basement Membrane for Breast Cancer Outcome and Immune Infiltration

International Journal of Biological Sciences, Год журнала: 2023, Номер 19(5), С. 1645 - 1663

Опубликована: Янв. 1, 2023

Therapeutic failure in breast cancer patients is largely attributed to postoperative advancement and therapy resistance.Nevertheless, an efficacious prognostic signature for recognizing this population lacking.The basement membrane (BM) has been proven be strongly involved progression metastasis, the potential a powerful predictor cancer.In study, substantial bulk RNA transcriptomics, single cell transcriptomics clinical information were collected from TCGA-BRCA, METABRIC GSE96058, Kaplan-Meier survival curves, analysis vitro experiments conducted validate signature.From results, index, namely, BMscore, was established with six pivotal BM genes, specifically LOXL1, FBLN1, FBLN5, SDC1, ADAMTS8 PXDNL.Verification by independent cohorts showed that high BMscore had distinctly worse outcome.By integrating factors, we constructed nomogram displayed good predictive capability.Furthermore, evaluated implication of immune infiltration.More importantly, positive correlation between EMT activity revealed immunohistochemistry experiments.Taken together, provided novel gene predict prognosis metastasis accurately, which may help individualized decision-making.

Язык: Английский

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