The Prostate, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 11, 2024
The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) plays a role in carcinogenesis is involved processes, such as proliferation, differentiation, drug resistance immunosuppression. STAT3 can be activated by phosphorylation tyrosine at position 705 (pSTAT3
Язык: Английский
Clinical Epigenetics, Год журнала: 2024, Номер 16(1)
Опубликована: Окт. 2, 2024
Язык: Английский
Процитировано
3
Critical Reviews in Oncology/Hematology, Год журнала: 2024, Номер 196, С. 104275 - 104275
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
2
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Год журнала: 2024, Номер 32(12), С. 1881 - 1890
Опубликована: Янв. 1, 2024
Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation.Therefore, it gaining increasing attention due to its safe and pharmacological applications.In this study, we investigated the role of CA in inhibiting Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer activator transcription-3 (STAT-3) mediated suppression proliferation signaling human prostate cells.Materials Methods: The colony formation abilities was studied using 3-[4,5dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay assays.Tumour death cycle arrest were identified flow cytometry techniques.CA treatment-associated protein expression mitogen-activated (MAPK) families, IL-6/JAK/STAT-3, proliferation, apoptosis expressions PC-3 LNCaP lines measured Western blot investigation.Results: We have obtained treatment with inhibits cells (PC-3 LNCaP) induces reactive oxygen species (ROS), arrest, concentration-dependent manner.Moreover, alleviates phosphorylated form MAPK i.e., extracellular signal-regulated 1 (ERK1), c-Jun N-terminal (JNK), p38 cells.IL-6 JAK/STAT3 regulate antiapoptosis leads metastasis migration.Therefore, mitigate IL-6/JAK/STAT-3 an important target for cancer.In observed IL-6, JAK1, STAT-3 both cells.Due inhibitory effect resulted decreased cyclin-D1, cyclin-D2, CDK1 cells.In addition, by enhancing Bax caspase-3; Bcl-2 cells.Conclusions: Thus, might act as therapeutical application against targeting IL-6/JAK/STAT3 axis.
Язык: Английский
Процитировано
2
Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155558 - 155558
Опубликована: Авг. 26, 2024
Язык: Английский
Процитировано
2
Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2024, Номер 12(6), С. 1165 - 1165
Опубликована: Май 24, 2024
To investigate the biological significance of Rho-associated coiled-coil-containing protein kinase (ROCK) 2 in human trabecular meshwork (HTM), changes both metabolic phenotype and gene expression patterns against a specific ROCK2 inhibitor KD025 were assessed planar-cultured HTM cells. A seahorse real-time ATP rate assay revealed that administration significantly suppressed glycolytic production increased mitochondrial RNA sequencing analysis 380 down-regulated 602 up-regulated differentially expressed genes (DEGs) identified cells treated with compared those untreated. Gene ontology DEGs more frequently related to plasma membrane, extracellular components integral cellular among components, signaling receptor binding activity heterodimerization molecular functions. Ingenuity Pathway Analysis (IPA) detected associated basic physiological properties, including movement, development, growth, proliferation, interaction, all which are metabolism. Furthermore, upstream regulator causal network estimated IL-6, STAT3, CSTA S1PR3 as possible regulators. Current findings herein indicate mediates IL-6/STAT3-, CSTA- S1PR3-linked activities such glycolysis
Язык: Английский
Процитировано
1
PLoS ONE, Год журнала: 2024, Номер 19(8), С. e0307038 - e0307038
Опубликована: Авг. 16, 2024
We previously demonstrated that glycyrrhizin (GL) suppressed inflammation and carcinogenesis in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced murine model of colorectal cancer (CC). In this study, we found accumulation regulatory T cells (Tregs) the spleen suppression by GL mice. ICR mice were divided into four groups: Control, GL, CC, GL-treated CC (CC+GL), sacrificed 20 weeks after AOM/DSS treatment. measured weight, areas white red pulp, CD8 + (cytotoxic lymphocytes, CTL), CD11c-positive (dendritic cells) splenic tissues forkhead box protein 3 (FoxP3)-positive tissues. all cases, group showed a significant increase compared with those Control group, administration significantly attenuated increase. These results indicate Tregs accumulated may participate inflammation-related suppressing CTL. also suggest which binds to high-mobility 1 (HMGB1), suppresses decreasing spleen. Furthermore, there was expression FoxP3 cells, indicating it be involved malignant transformation cells.
Язык: Английский
Процитировано
1
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(9), С. 10140 - 10159
Опубликована: Сен. 14, 2024
Prostate cancer (PCa) is a common and deadly disease in men. It often diagnosed at advanced stages, which point patients are treated mainly with docetaxel (DTX), effective but limited by resistance side effects. Overactivation of the transcription factors NF-κB STAT-3 plays critical role development, progression, chemoresistance PCa. In this regard, blockade pentoxifylline (PTX) or Stattic (STT) known to increase sensitivity tumor cells chemotherapy both vitro vivo models. We investigated whether simultaneous PTX STT increases efficacy DTX treatment inducing apoptosis metastatic castration-resistant PCa DU-145 cells. Our results showed that combination + led higher levels apoptosis, regardless not was present treatment. Determining caspases ΔΨm indicates intrinsic caspase pathway principally favored. addition, inhibited proliferation colony formation arrested cell cycle G1 phase. These indicate inhibitor could potentiate effectively, opening possibility treatments
Язык: Английский
Процитировано
1
Pathology - Research and Practice, Год журнала: 2024, Номер 265, С. 155748 - 155748
Опубликована: Ноя. 28, 2024
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Май 9, 2024
Abstract Oral cancer stands as a prevalent maligancy worldwide; however, its therapeutic potential is limited by undesired effects and complications. As medicinal edible fungus, Chaga mushroom ( Inonotus obliquus ) exhibits anticancer across diverse cancers. Yet, the precise mechanisms underlying efficacy remain unclear. We explored detailed action of extract in oral cells (HSC-4). Following treatment with extracts, we analyzed cell viability, proliferation capacity, glycolysis, mitochondrial respiration, apoptosis. Our findings revealed that reduced viability HSC-4 while arresting their cycle via suppression STAT3 activity. Regarding energy metabolism, inhibited glycolysis membrane cells, thereby triggering autophagy-mediated apoptotic death through activation p38 MAPK NF-κB signaling pathways. results indicate impedes progression, inhibiting proliferation, suppressing promoting death. These suggest this promising supplementary medicine for patients cancer.
Язык: Английский
Процитировано
0