Journal of Ethnopharmacology, Год журнала: 2023, Номер 318, С. 116893 - 116893
Опубликована: Июль 8, 2023
Язык: Английский
Pharmaceuticals, Год журнала: 2023, Номер 16(5), С. 712 - 712
Опубликована: Май 7, 2023
In recent years, the potential role of probiotics has become prominent in discoveries neurotherapy against neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties exert their effects via various mechanisms actions. This review aimed to evaluate LAB on neuroprotection reported literature.
Язык: Английский
Процитировано
29
Molecules, Год журнала: 2024, Номер 29(8), С. 1691 - 1691
Опубликована: Апрель 9, 2024
Astragali radix is a traditional medicinal herb with long history and wide application. It frequently used in prescriptions other materials to replenish Qi. According the classics of Chinese medicine, attributed properties such as Qi replenishing surface solidifying, sore healing muscle generating, inducing diuresis reduce edema. Modern pharmacological studies have demonstrated that some extracts active ingredients function antioxidants. The polysaccharides, saponins, flavonoids offer beneficial effects preventing controlling diseases caused by oxidative stress. However, there still lack comprehensive research on effective components molecular mechanisms through which exerts antioxidant activity. In this paper, we review radix; summarize content, bioavailability, mechanisms; reference for clinical application Astragalus future development novel
Язык: Английский
Процитировано
13
CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background Ischemic stroke is a prevalent and life‐threatening cerebrovascular disease that challenging to treat associated with poor prognosis. Astragaloside IV (AS‐IV), primary bioactive component of Astragali radix , has demonstrated neuroprotective benefits in previous studies. This study aimed explore the mechanisms through which AS‐IV may cerebral ischemia–reperfusion injury (CIRI). Methods Network pharmacology was employed identify key targets pathways CIRI therapy, combined molecular docking predict binding affinity. Male Sprague–Dawley rats were randomly assigned sham, MCAO/R, AS‐IV, SP600125 (JNK inhibitor), + SP600125, 3‐n‐Butylphthalide (NBP) groups. Neurobehavioral deficits assessed, brain tissue damage visualized 2,3,5‐triphenyltetrazolium chloride, H&E, TUNEL staining. Immunohistochemistry detect CytC‐ caspase‐3‐positive cells, while Western blotting, qPCR, ELISAs used analyze apoptosis‐related markers. Results A total 48 predicted be involved treatment identified, enriched 136 pathways. effectively bound top five from targets, those c‐Jun N‐terminal kinase (JNK)/Bid pathway, energy values below −5.0 kJ·mol −1 . JNK inhibition reduced infarcted areas, improved neurological function, pathological damage, inhibited apoptosis, achieving similar effects. Both p‐JNK, Bid, CytC, Apaf‐1, caspase‐3, cleaved caspase‐3 levels decreasing caspase‐9 serum. Conclusion suppress apoptosis partly modulation JNK/Bid signaling, exerting These findings support potential development AS‐IV‐based therapies for treatment.
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2024, Номер 325, С. 117766 - 117766
Опубликована: Янв. 22, 2024
Язык: Английский
Процитировано
7
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
7
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(4)
Опубликована: Апрель 1, 2024
Abstract Objectives Astragaloside IV (AST IV) and ligustrazine (Lig), the main ingredients of Astragali Radix Chuanxiong Rhizoma respectively, have demonstrated significant benefits in treatment cerebral ischemia ‐reperfusion injury (CIRI); however, mechanisms underlying its benificial effects remain unclear. SUMO‐1ylation deSUMO‐2/3ylation dynamin‐related protein 1 (Drp1) results mitochondrial homeostasis imbalance following CIRI, which subsequently aggravates cell damage. This study investigates by AST combined with Lig protects against focusing on involvement SUMOylation dynamics. Methods Rats were administrated for 7 days, middle artery occlusion was established to mimic CIRI. Neural function, infarction volume, blood flow, cognitive cortical pathological lesions, morphology measured. SH‐SY5Y cells subjected oxygen–glucose deprivation/reoxygenation (OGD/R) injury. Mitochondrial membrane potential lactic dehydrogenase (LDH), reactive oxygen species (ROS), adenosine triphosphate (ATP) levels assessed commercial kits. Moreover, co‐immunoprecipitation (Co‐IP) used detect binding SUMO1 SUMO2/3 Drp1. The expressions Drp1, Fis1, MFF, OPA1, Mfn1, Mfn2, SUMO1, SUMO2/3, SENP1, SENP2, SENP3, SENP5, SENP6 measured using western blot. Results In rats improved neurological functions, restored CBF, reduced brain infarct alleviated neuron cells, combination enhanced cellular viability, decreased release LDH ROS, increased ATP content, potential. Furthermore, Drp1 suppressed SENP5. overexpression promoted fission inhibited fusion, whereas fission. could reverse while enhancing those overexpression. Conclusions posits that has reduce augment SUMO‐2/3ylation thereby exert a protective effect
Язык: Английский
Процитировано
6
Journal of Ethnopharmacology, Год журнала: 2023, Номер 314, С. 116575 - 116575
Опубликована: Май 2, 2023
Язык: Английский
Процитировано
15
Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15
Опубликована: Авг. 4, 2023
Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen species (ROS), which leads to oxidation cellular proteins, DNA, and lipids as an initial event. The reperfusion process impairs critical cascades that support cell survival, including mitochondrial biogenesis antioxidant enzyme activity. Failure activate prosurvival signals may result in increased neuronal death exacerbation CIR damage. Melatonin, a hormone produced naturally body, has high concentrations both cerebrospinal fluid brain. However, melatonin production declines significantly with age, contribute development age-related neurological disorders due reduced levels. By activating various signaling pathways, can affect multiple aspects human health its diverse range activities. Therefore, understanding underlying intracellular molecular mechanisms crucial before investigating neuroprotective effects cerebral injury.
Язык: Английский
Процитировано
13
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Фев. 20, 2024
The incidence of lumbar disc herniation has gradually increased in recent years, and most patients have symptoms low back pain nerve compression, which brings a heavy burden to society alike. Although the causes are complex, intervertebral degeneration (IDD) is considered be common factor. (IVD) composed upper lower cartilage endplates, nucleus pulposus, annulus fibrosus. Aging, abnormal mechanical stress load, metabolic disorders can exacerbate progression IDD. Among them, high glucose high-fat diets (HFD) lead fat accumulation, metabolism, inflammation, important factors affecting homeostasis Diabetes advanced glycation end products (AGEs) accumulation- various adverse effects on IVD, including cell senescence, apoptosis, pyroptosis, proliferation, Extracellular matrix (ECM) degradation. While current research provides fundamental basis for treatment glucose-induced IDD patients. further exploration into mechanisms metabolism development targeted drugs will provide foundation effective these We aimed systematically review studies regarding hyperglycemia progress
Язык: Английский
Процитировано
4
Neuroscience, Год журнала: 2025, Номер 568, С. 195 - 201
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
0