Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 31, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 486, С. 149958 - 149958
Опубликована: Фев. 24, 2024
Язык: Английский
Процитировано
2
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Апрель 24, 2024
Abstract The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as cofactor for important proteins such hemoglobin, myoglobin, oxidative respiratory chain, DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF associated with iron dysmetabolism, deficiencies overload can both lead to development various myocarditis diseases, which ultimately progress HF. toxicity may be key targets diagnosis, treatment, prevention Some chelators (such desferrioxamine), antioxidants ascorbate), Fer-1, molecules regulate levels lactoferrin) been effective treating protecting myocardium studies. Additionally, certain natural compounds significant by mediating imbalance iron-related signaling pathways expression levels. Therefore, this review not only summarizes basic processes body mechanisms they HF, aim providing new clues considerations treatment but also on chemical components involve ferroptosis its pathology, well naturally occurring products reference information inhibitors future.
Язык: Английский
Процитировано
2
BMC Cancer, Год журнала: 2024, Номер 24(1)
Опубликована: Июнь 4, 2024
Abstract Background Astragaloside IV (AS-IV) is one of the basic components Astragali radix , that has been shown to have preventive effects against various diseases, including cancers. This study aimed explore role AS-IV in hepatocellular carcinoma (HCC) and its underlying mechanism. Methods The cell viability, glucose consumption, lactate production, extracellular acidification rate (ECAR) SNU-182 Huh7 lines were detected by specific commercial kits. Western blot was performed analyze succinylation level lines. interaction between lysine acetyltransferase (KAT) 2 A phosphoglycerate mutase 1 (PGAM1) evaluated co-immunoprecipitation immunofluorescence assays. KAT2A vivo explored using a xenografted tumor model. Results results indicated treatment downregulated protein levels ECAR, decreased AS-IV-treated lines, reversed after overexpression. interacted with PGAM1 promote at K161 site. overexpression promoted viability glycolysis which partly blocked following inhibition. In tumor-bearing mice, suppressed growth though inhibiting KAT2A-mediated PGAM1. Conclusion inhibited HCC regulating PGAM1, suggesting might be potential suitable therapeutic agent for treating HCC.
Язык: Английский
Процитировано
2
Journal of Asian Natural Products Research, Год журнала: 2024, Номер unknown, С. 1 - 9
Опубликована: Июнь 10, 2024
Astragali Radix (AR), a common traditional Chinese medicinal herb, exhibits protective effects on diabetic nephropathy (DN) in extensive researches. Aticles focusing AR PubMed were collected and reviewed order to summarize the latest pharmacological DN. The action mechanisms for protectiving of associated with regulation anti-fibrosis, anti-inflammation, anti-oxidative stress, anti-podocyte apoptosis, restoration mitochondrial function, endothelial function diabetes experimental models. Consequently, hold promise as potential novel therapeutics treatment
Язык: Английский
Процитировано
2
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 31, 2024
Язык: Английский
Процитировано
2