South African Journal of Botany, Год журнала: 2024, Номер 172, С. 254 - 266
Опубликована: Июль 26, 2024
Язык: Английский
Fungal Biology Reviews, Год журнала: 2025, Номер 51, С. 100413 - 100413
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
11
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Фев. 15, 2024
Abstract Regarding different medical benefits of fungi, using the mushroom extracts as wound-healing agents is gaining popularity. This study, evaluated wound healing characteristics Trametes versicolor . Anti-oxidant activity addressed by employing DPPH (2,2-diphenyl-1-picrylhydrazyl) assay resulting 53.7% inhibitory effect. Besides, for anti-microbial ability determination, MIC (Minimum Inhibitory Concentration) extract measured which Escherichia coli growth was inhibited at 1.1 mg/ml, and Staphylococcus aureus did not grow 4.38 mg/ml extract. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method indicated dose dependence with 63 ± 3% 28 viability 1250 μg/ml 156.25 extract, higher concentration caused cell viability. outcome gene expression analysis determined that overall FGF2 (Fibroblast Growth Factor 2), IL-1β (Interleukin-1β), TGF-β1 (Transforming Factor-β1) 4 times 48 h than 24 in treated cells, suggesting a stimulating effect on growth. An in-vivo animal model suggested enhanced process after treatment 0.01 g Furthermore, number fibroblasts, epidermal thickness, collagen fiber respectively 2, 3, threefold mice when compared to untreated mice. wounds showed 100% 60% within 14 days. results this research show promise fungus-based treatments, may help tissue regeneration cutaneous wounds.
Язык: Английский
Процитировано
7
Current Opinion in Food Science, Год журнала: 2024, Номер 58, С. 101191 - 101191
Опубликована: Июль 1, 2024
Macrofungi, commonly known as mushrooms, are not only considered functional foods for supplying essential nutritional ingredients but also a good source of physiologically beneficial medicines. Trametes versicolor, referred to turkey tail's Mushroom or Yun Zhi in China, is an edible mushroom that has extensive historical usage conventional and traditional Chinese medicine. This contains abundance bioactive compounds, most notably β-glucan polysaccharides, which responsible antioxidant, neuroprotection, hypolipidemic effects, immune-modulating anticancer effects. versicolor been revealed have wound healing, antidiabetic, antimicrobial, antifibrotic, neurotrophic, anti-inflammatory effects among other therapeutic efficacies. review paper overviewed the recent advances research study on discussed potential health-promoting properties this exotic macrofungi, with recognition polysaccharide constituents these medicinal agents.
Язык: Английский
Процитировано
4
Journal of Fungi, Год журнала: 2025, Номер 11(1), С. 81 - 81
Опубликована: Янв. 20, 2025
Trametes versicolor is an important fungus with medicinal properties and a significant role in lignocellulose degradation. In this study, we constructed high-quality chromosome-level genome of T. using Illumina, PacBio HiFi, Hi-C sequencing technologies. The assembled 47.42 Mb size contains 13,307 protein-coding genes. BUSCO analysis revealed gene completeness results 95.80% 95.90%, respectively. Phylogenetic showed that most closely related to pubescens, followed by cinnabarina coccinea. Comparative genomic identified 266 syntenic blocks between Wolfiporia cocos, indicating conserved evolutionary pattern the two species. Gene family highlighted expansion contraction genes functional categories biosynthesis secondary metabolites, including several versicolor-specific Key involved degradation triterpene production were within CAZyme CYP450 families. Transcriptomic under dark light conditions changes expression metabolism, suggesting signals regulate metabolic pathways. A total 2577 transporter proteins 2582 membrane mapped genome, 33 metabolite clusters identified, light-sensitive clusters. This study offers comprehensive resource for further investigation into genomics, regulation, versicolor, providing valuable insights fungal evolution biotechnological applications.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1556 - 1556
Опубликована: Фев. 12, 2025
Coriolus versicolor (CV), known in traditional Chinese medicine for over 2000 years, is currently used China and Japan to reduce chemotherapy or radiotherapy side effects cancer patients. Despite extensive research, its still need improvement. This study aimed determine if combining CV extract with LY294002, an inhibitor of the phosphatidylinositol-3-kinase (PI3K) signalling pathway, enhances cell treatment, potentially leading a novel therapeutic approach. Three human lines (MCF-7, HeLa, A549) were treated alone combined LY294002. Cell viability was assessed using MTT assays. Then, HeLa MCF-7 cells most sensitive co-treatment evaluate colony formation, apoptosis, cycle, migration invasion, phospho-PI3K expression. The results demonstrated that LY294002 enhanced extract's anti-tumour by reducing formation. treatment more effectively induced G0/G1 cycle arrest, promoted reduced invasion migration, inhibited expression compared each agent alone. highlights potent cytotoxic enhancement between on cells, primarily inhibiting These findings suggest promising avenues developing combination therapies targeting cancer.
Язык: Английский
Процитировано
0
Опубликована: Март 20, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2024, Номер 6(5)
Опубликована: Май 9, 2024
Abstract This comprehensive literature review delves into the multifaceted attributes of Trametes versicolor , commonly known as turkey tail mushroom. The mushroom stands a noteworthy source diverse bioactive compounds with potent health benefits. offers contemporary synthesis its phytochemical constituents and their impacts on human health. mushroom's intricate composition, encompassing polysaccharides, phenols, triterpenes, underpins remarkable therapeutic potential. Focusing key such anti-cancer, anti-microbial, immunomodulatory activities, this mechanisms by which exerts effects. In addition, exploration extends to enzymatic inherent in industrial significance. Mechanisms action for both phytochemicals enzymes are studied, providing well-rounded understanding roles conferring research aims provide an up-to-date perspective mushrooms' versatile applications. By intertwining benefits constituents, insights potential harnessing natural resource innovative strategies Overall, it contributes advancement knowledge utilisation properties progress.
Язык: Английский
Процитировано
3
Frontiers in Fungal Biology, Год журнала: 2024, Номер 5
Опубликована: Июнь 11, 2024
Mushrooms are widely available around the world and have various nutritional as well therapeutic values. Many Asian cultures believe that medicinal mushrooms can prolong life improve vitality. This study aims to characterize phytochemical polysaccharide content, mainly β-glucan of mycelial biomass fruiting bodies collected from Himalayan region, particularly Uttarakhand. Through molecular analysis LSU F/R-rDNA fragment sequence phylogenetic analysis, strain was identified
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15596 - 15596
Опубликована: Окт. 26, 2023
Mushrooms are new potential sources of valuable medicines, long neglected because difficulties experienced in their cultivation. There is a large variety medicinal mushrooms which possess significant therapeutic properties and used as medications for various diseases they contain several novel highly bioactive components. Medicinal can be identified based on morphology, size, mass, the color stalk, cap spore, attachment to stalk. important biological activities antioxidants, hepatoprotectors, anticancer, antidiabetic, anti-inflammatory, antiaging, antiviral, antiparasitic, antimicrobial agents, among others. This review provides basic overview chemical scaffolds present implications human body.
Язык: Английский
Процитировано
7
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 181 - 218
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0