IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 23, 2024
Viruses
are
always
dependent
on
their
host
in
many
ways.
They
especially
rely
the
cellular
machinery
of
cell
for
replication.
In
this
regard,
epigenetic
regulation
is
one
influential
factors
during
viral
infections.
Hepatitis
B
virus
(HBV)
involved
developing
hepatocellular
carcinoma
(HCC)
by
different
mechanisms.
Both
HBc
and
HBx
proteins
able
to
interfere
with
While
role
has
not
yet
been
defined
detail,
shown
have
multiple
effects
machinery,
including
interaction
methyltransferases
(DNMTs),
(HMTs),
histone
deacetylases
(HDACs),
acetyltransferases
(HATs),
m6A
modification,
MiRNA.
Also,
it
impairs
immune
function
modulate
expression
genes
associated
HBV-induced
HCC.
Therefore,
chapter
aims
provide
an
overview
HBV-related
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(6), С. 1824 - 1842
Опубликована: Янв. 1, 2024
In
this
review,
we
briefly
summarize
the
recent
research
progress
in
enantioselective
higher-order
cycloadditions,
focusing
on
preparation
of
medium-sized
and
multicyclic
chiral
molecules
by
metal-free
catalysis.
Chemical Research in Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Cadmium
(Cd)
is
a
prevalent
environmental
and
industrial
contaminant
that
causes
significant
damage
to
liver
function.
However,
the
role
of
m6A
methylation─a
critical
epigenetic
modification─in
Cd-induced
injury
remains
poorly
understood.
This
study
aimed
investigate
effects
methylation
in
damage.
A
mouse
model
was
established,
exposure
CdCl2
(20
mg/kg)
for
90
days
resulted
reduced
levels.
Using
methylated
RNA
immunoprecipitation
sequencing
(MeRIP-seq)
(RNA-Seq),
we
characterized
profiles
both
control
Cd-exposed
groups.
total
8355
unique
peaks
1,101
m6A-modified
genes
were
identified.
Among
these,
673
exhibited
differential
modifications,
including
463
hyper-methylated
210
hypo-methylated
genes.
Conjoint
analysis
MeRIP-seq
RNA-Seq
data
unveiled
showed
expression.
These
significantly
enriched
AGE-RAGE
PI3K-Akt
signaling
pathway.
Through
bioinformatics
screening,
five
key
(Il-1β,
Ccl2,
Tlr2,
Itgax,
Ccr2)
identified,
expression
validation
indicated
Itgax
Ccr2
may
play
pivotal
roles
injury.
Notably,
elevated
methyltransferase-like
14
(METTL14)
observed
vivo
vitro
models.
Inhibition
Mettl14
can
regulate
inflammation
through
m6A-dependent
regulation
Collectively,
our
findings
highlight
crucial
injury,
providing
novel
insights
into
mechanisms
underlying
diseases
potential
biomarkers
diagnosis
therapy.
Journal of Physiology and Biochemistry,
Год журнала:
2023,
Номер
79(4), С. 901 - 924
Опубликована: Авг. 25, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
multifactorial
condition
with
complex
etiology.
Its
incidence
increasing
globally
in
parallel
the
obesity
epidemic,
and
it
now
considered
most
common
Western
countries.
The
precise
mechanisms
underlying
development
progression
of
NAFLD
are
still
poorly
understood.
dysregulation
epigenetic
epitranscriptomic
increasingly
recognized
to
play
pathogenic
roles
multiple
conditions,
including
chronic
diseases.
Here,
we
have
performed
comprehensive
analysis
expression
genes
total
903
tissue
samples
corresponding
patients
normal
liver,
obese
patients,
non-alcoholic
(NAFL)
steatohepatitis
(NASH),
advancing
stages
progression.
We
integrated
ten
transcriptomic
datasets
an
unbiased
manner,
enabling
their
robust
comparison.
describe
complete
landscape
genes'
along
course
disease.
identify
signatures
significantly
dysregulated
association
progression,
particularly
fibrosis
development.
Most
these
effectors
not
been
previously
described
human
NAFLD,
altered
may
implications.
also
enzymes
involved
metabolism
substrates
cofactors
effectors.
This
study
provides
novel
information
on
pathogenesis
guide
identification
drug
targets
treat
this
its
towards
hepatocellular
carcinoma.
