The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1313 - 1313

Опубликована: Окт. 28, 2024

Rosmarinic acid (RA), a polyphenolic compound found in herbs, such as rosemary, basil, and mint, has garnered significant attention due to its potent antioxidant anticancer properties. This review examined the molecular mechanisms underlying these properties their potential application cancer prevention therapy. It focuses specifically on RA's role modulating cancer-related pathways presents detailed analysis of recent advancements this area. A systematic PubMed, Scopus, Web Science databases was conducted accordance with PRISMA (Reporting Items for Systematic Reviews Meta-Analysis) guidelines, focusing studies published between 2019 2024. total 25 articles providing evidence from vitro, vivo, silico were selected. These findings elucidate RA inhibiting tumor cell proliferation, inducing apoptosis, preventing metastasis various types through diverse mechanisms, including Despite promising results, bioavailability challenges limit therapeutic efficacy, underscoring necessity improved delivery methods. concludes that exhibits natural agent treatment, although further clinical trials are warranted.

Язык: Английский

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Global Interactome Mapping Reveals Pro-tumorigenic Interactions of NF-κB in Breast Cancer

Molecular & Cellular Proteomics, Год журнала: 2024, Номер 23(4), С. 100744 - 100744

Опубликована: Фев. 28, 2024

Язык: Английский

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Inhibition of NF-κB-Mediated Proinflammatory Transcription by Ru(II) Complexes of Anti-Angiogenic Ligands in Triple-Negative Breast Cancer

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(7), С. 5902 - 5923

Опубликована: Март 23, 2024

Nuclear factor kappa beta (NF-κB) plays a pivotal role in breast cancer, particularly triple-negative by promoting inflammation, proliferation, epithelial–mesenchymal transition, metastasis, and drug resistance. Upregulation of NF-κB boosts vascular endothelial growth (VEGF) expression, assisting angiogenesis. The Ru(II) complexes methyl- dimethylpyrazolyl-benzimidazole N,N donors inhibit phosphorylation ser536 p65 translocation the heterodimer (p50/p65) to nucleus, disabling transcription upregulate inflammatory signaling. VEGFR2 at Y1175, disrupting downstream signaling through PLC-γ ERK1/2, ultimately suppressing Ca(II)-signaling. Partial release antiangiogenic ligand reactive oxygen species-rich environment is possible as per our observation both complexes. are nontoxic zebrafish embryos up 50 μM, but ligands show strong vivo activity 3 μM during embryonic Tg(fli1:GFP) no visible effect on adult phase.

Язык: Английский

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Spices and culinary herbs for the prevention and treatment of breast cancer: A comprehensive review with mechanistic insights

Cancer Pathogenesis and Therapy, Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Breast cancer (BC) continues to be the primary malignant neoplasm affecting women. For many years, traditional approaches such as chemotherapy, hormone therapy, radiation, and surgical interventions have been employed treat BC. However, these therapies often fall short due considerable adverse effects development of multidrug resistance or tolerance. Spices culinary herbs that utilized in practices for millennia also demonstrated therapeutic medicinal serving both prevent This review aims comprehensively explore roles underlying mechanisms through which spices exert anti-BC properties. These natural ingredients exhibit diverse encompass mechanisms, including inhibition BC cell proliferation, migration, metastasis, angiogenesis, well induction cycle arrest apoptosis. actions are achieved by targeting signaling pathways phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target rapamycin (mTOR), notch signaling, Hedgehog nuclear factor kappa-light-chain-enhancer activated cells (NF-κB), Wingless/int (Wnt)/β-catenin predominantly overexpressed breast tumors exploited them promote progression. Additionally, compounds curcumin, allicin, gingerol, zerumbone, diosgenin, capsaicin, piperine, quercetin, malabaricone C, eugenol, cardamomin, carnosol, cinnamaldehyde, sinigrin present may more effective with reduced side against compared conventional chemotherapeutic drugs. presents a concise overview potential contributions spices, herbs, their potent bioactive constituents BC, particular emphasis on elucidating action.

Язык: Английский

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Analysis of neuroglia and immune cells in the tumor microenvironment of breast cancer brain metastasis

Cancer Biology & Therapy, Год журнала: 2024, Номер 25(1)

Опубликована: Сен. 5, 2024

Breast cancer stands as the most prevalent diagnosed worldwide, often leading to brain metastasis, a challenging complication characterized by high mortality rates and grim prognosis. Understanding intricate mechanisms governing breast metastasis (BCBM) remains an ongoing challenge. The unique microenvironment in fosters ideal setting for colonization of cells. tumor (TME) metastases plays pivotal role initiation progression BCBM, shaping landscape targeted therapeutic interventions. Current research primarily concentrates on unraveling complexities TME with particular emphasis neuroglia immune cells, such microglia, monocyte-derived macrophages (MDMs), astrocytes T This comprehensive review delves deeply into these elements within shedding light their interplay, mechanisms, potential targets combat BCBM.

Язык: Английский

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Synergistic effects of sequential treatment with doxorubicin and zoledronic acid on anticancer effects in estrogen receptor-negative breast cancer cells

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Язык: Английский

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Harnessing the anticancer potential of Piper nigrum: a synergistic approach to chemotherapy enhancement and reduced side effects

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 6, 2025

Cancer therapy continues to face critical challenges, including drug resistance, recurrence, and severe side effects, which often compromise patient outcomes quality of life. Exploring novel, cost-effective approaches, this review highlights the potential Piper nigrum (black pepper) extract (PNE) as a complementary anticancer agent. nigrum, widely available spice with rich history in traditional medicine, contains bioactive compounds such piperine, have demonstrated significant activities cell cycle arrest, apoptosis induction, inhibition tumor growth metastasis. The evaluates recent findings from vitro, vivo, clinical studies, emphasizing PNE's capacity enhance efficacy conventional chemotherapeutic agents while mitigating their effects. Key mechanisms underlying these effects include oxidative stress modulation, suppression pro-metastatic factors, synergistic interactions established drugs like doxorubicin paclitaxel. These suggest that PNE could play pivotal role overcoming chemoresistance improving therapeutic outcomes. Furthermore, benefits resource-limited settings, where cost cancer treatments restricts access. However, challenges compositional variability, limited bioavailability, need for standardization validation be addressed advance integration into basic oncology. By providing comprehensive analysis its adjuvant therapy, provides new insight exploitation improve treatment reducing Future research directions are discussed address current limitations facilitate translation.

Язык: Английский

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Roles of Post-Translational Modifications of Transcription Factors Involved in Breast Cancer Hypoxia

Molecules, Год журнала: 2025, Номер 30(3), С. 645 - 645

Опубликована: Фев. 1, 2025

BC is the most commonly diagnosed cancer and second leading cause of death among women worldwide. Cellular stress a condition that leads to disrupted homeostasis by extrinsic intrinsic factors. Among other stressors, hypoxia driving force for breast (BC) progression general hallmark solid tumors. Thus, intratumoral an important determinant invasion, metastasis, treatment failure, prognosis, patient mortality. Acquisition epithelial–mesenchymal transition (EMT) phenotype also consequence tumor hypoxia. The cellular response mainly regulated signaling pathway, governed hypoxia-inducible factors (HIFs), HIF1α. HIFs are family transcription (TFs), which induce expression target genes involved in cell survival proliferation, metabolic reprogramming, angiogenesis, resisting apoptosis, metastasis. HIF1α cooperates with large number TFs. In this review, we focused on crosstalk cooperation between TFs BC. We identified cluster TFs, proposed as HIF1α-TF interactome, orchestrates hypoxia, due their post-translational modifications (PTMs), including phosphorylation/dephosphorylation, ubiquitination/deubiquitination, SUMOylation, hydroxylation, acetylation, S-nitrosylation, palmitoylation. PTMs these HIF1α-related drive stability activity, degradation turnover, bidirectional translocation cytoplasm or plasma membrane nucleus cells, well transcription/activation proteins encoded oncogenes inactivation suppressor genes. Consequently, interactome crucial regulatory mechanisms oxygen deprivation cells.

Язык: Английский

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An update understanding of stemness and chemoresistance of prostate cancer

Expert Review of Anticancer Therapy, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Globally, prostate cancer (CaP) is a leading cause of death and disability among men substantial public health burden. Despite advancements in treatment, chemoresistance remains significant issue therapy, accounting for the majority patient relapses poor survival. Cancer stem cells (CSCs) are considered main recurrence, chemoresistance, survival patients. These CSCs acquire stemness by certain mechanisms such as enhanced DNA repair processes, increased expression drug efflux pumps, resistance to apoptosis, altered cell cycle tumor microenvironment (TME). We cover latest developments this field give an overview future research directions. show dysregulation several signaling pathways, mostly related conferring phenotype, high efflux, apoptotic resistance, quiescent cycle, microenvironment, repair. There articles published on topic. However, still, warrants further investigations identify therapeutic molecule that can either chemosensitize or kill them effectively. This only be possible when we know complete comprehend fundamental causes therapy resistance.

Язык: Английский

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The role of the transcription factor NF-kB in the pathogenesis of inflammation and carcinogenesis. Modulation capabilities

Pharmacia, Год журнала: 2025, Номер 72, С. 1 - 13

Опубликована: Фев. 20, 2025

The nuclear factor kappa B (NF-kB) signaling module is a complex and highly interconnected molecular network with important functions in all nucleated cells. Most chronic diseases caused by lifestyle factors appear to be related inflammation. NF-kB plays major role the pathogenesis of inflammation its intimate mechanism. This transcription participates evolution diabetes complications. In T1D (Type 1 Diabetes), proinflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis (TNF), CD40L secreted immune cells islets induce activation β-cells through both canonical noncanonical roads. increases expression genes, including TNF-α, IL-1β, IL-6, MCP-1, ICAM-1, that initiate promote atherosclerosis. particular, severity lethality acute lung injury or respiratory distress syndrome (ALI/ARDS) pneumonia sepsis primarily associated an NF-kB-mediated “cytokine storm,” which massive polymorphonuclear (PMN) extravasation subsequent release cause rapid deterioration due widespread coagulation. Nuclear translocation p65 can several genes involved induction EMT (epithelial-to-mesenchymal transition). has been confirmed various types cancer, brain, breast, lung, gastric cancer. Cutaneous T-cell lymphoma (CTCL) encompasses group lymphoproliferative disorders characterized invasive neoplastic T skin clinical prognoses. early stages CTCL, cell proliferation are stimulated autocrine production TNFα, leading increased resistance apoptosis. Bladder cancer second most common genitourinary often recurrent and/or chemoresistant after resection. critical normal physiology bladder patients have pathologically active induced cytokines, chemokines, hypoxia, enhancing carcinogenesis progression disease.

Язык: Английский

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