Cardiovascular Innovations and Applications,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 1, 2025
Diabetic
cardiomyopathy
(DCM),
an
independent
diabetes
complication,
is
characterized
by
abnormalities
in
myocardial
structure,
function,
and
metabolism,
including
diminished
contractility,
hypertrophy,
fibrosis.
Factors
such
as
hyperglycemia,
metabolic
disorders,
microangiopathy,
inflammation,
oxidative
stress,
insulin
resistance
have
been
found
to
play
important
roles
DCM
pathophysiology.
Recent
research
has
shown
that
miRNAs
are
involved
processes
cell
proliferation,
differentiation,
metastasis,
promote
the
progression
of
DCM.
Despite
these
insights,
regulatory
effects
on
immune
function
remain
inadequately
explored.
This
review
synthesizes
current
advancements
understanding
miRNA-mediated
regulation
We
highlight
need
for
further
elucidate
complex
interactions
between
pathways
DCM,
which
might
reveal
novel
therapeutic
targets
mitigate
this
debilitating
condition.
Targeted
B
cells,
macrophages,
T
cells
through
immune-associated
open
new
avenues
intervention.
Developing
efficient
delivery
systems
miRNA-based
therapies
ensure
targeted
enhance
stability.
Additionally,
combining
existing
hypoglycemic
drugs
with
produce
anti-inflammatory
anti-fibrotic
effects,
thereby
improving
outcomes.
Abstract
Wounds
in
patients
with
diabetes
present
significant
physical
and
economic
challenges
due
to
impaired
healing
prolonged
inflammation,
exacerbated
by
complex
interactions
between
microbes.
Especially,
the
development
of
diabetic
foot
ulcers
(DFUs)
remain
an
urgent
clinical
problem.
The
human
gut
harbors
a
vast
microbial
ecosystem
comprising
intestinal
flora
their
metabolic
products.
Recent
advancements
research
have
illuminated
concept
“gut‐skin
axis,”
revealing
intricate
relationships
microbiota,
microbiota‐derived
metabolites,
various
skin
diseases,
including
DFUs.
This
review
aims
unravel
formation
process
DFUs
context
gut‐skin
axis.
We
reviewed
current
progress
worldwide
regarding
axis,
compared
discussed
changes
microbiota
colonizing
roles
metabolites
such
as
lipopolysaccharides,
short‐chain
fatty
acids,
trimethylamine‐N‐oxide
are
highlighted.
also
treatment
strategies
currently
employed
practice
identified
potential
therapeutic
targets
probiotics
for
treating
need
more
comprehensive
experimental
designs
elucidate
relationship
its
therefore
Experimental and Molecular Pathology,
Год журнала:
2025,
Номер
142, С. 104964 - 104964
Опубликована: Апрель 8, 2025
The
gut-lung
axis,
a
vital
signaling
network
linking
the
gastrointestinal
and
pulmonary
systems,
regulates
immune
responses
progression
of
respiratory
diseases.
Nutritional
components
can
modulate
gut
microbiome
regulate
synthesis
critical
intestinal
microbial
metabolites,
which
are
essential
for
maintaining
homeostasis
supporting
health.
Conversely,
poor
dietary
habits
exacerbate
asthma
other
conditions
through
modulation
systemic
inflammation
responses.
Dietary
interventions,
such
as
Mediterranean
diet,
reported
to
restore
balance
improve
health
by
increasing
production
anti-inflammatory
potentiating
responses,
preserving
epithelial
barrier
integrity.
In
contrast,
Western
patterns,
characterized
high
fat
low
fiber
intake,
disrupt
diversity,
resulting
in
increased
levels
pro-inflammatory
metabolites
that
aggravate
airway
severity.
This
review
aimed
elucidate
mechanisms
underlying
regulatory
effects
microbes
their
on
asthma.
Additionally,
previous
findings
related
axis
have
been
summarized,
providing
insights
into
potential
therapeutic
strategies
management.
Veterinary Sciences,
Год журнала:
2025,
Номер
12(4), С. 354 - 354
Опубликована: Апрель 10, 2025
This
study
aims
to
explore
the
therapeutic
potential
of
Angelicae
Pubescentis
Radix
(APR),
a
traditional
Chinese
medicine
that
is
widely
known
for
its
anti-inflammatory,
anti-oxidative,
and
anti-microbial
properties,
using
mouse
model.
In
this
study,
30
mice
were
selected
divided
into
three
groups:
control
group
(CD),
infection
(ED),
treatment
(TD).
Mice
in
TD
gavaged
with
APR
oil
(0.15
mL/kg/day)
20
days,
while
CD
ED
received
an
equal
volume
normal
saline.
On
21st
day,
infected
multi-drug-resistant
E.
coli
(1
×
107
CFU/mL)
derived
from
diarrheal
yak.
Twenty-four
hours
later,
all
euthanized,
blood,
organs,
intestinal
samples
collected
analysis.
The
results
sections
bacterial
load
revealed
significantly
reduced
(p
<
0.05)
both
injury.
Serum
analysis
indicated
also
alleviated
inflammation
oxidative
stress
induced
by
infection.
Intestinal
microbiota
sequencing
further
showed
increased
abundance
probiotics
such
as
Ligilactobacillus,
Paludicola,
Blautia_A_1417806
enhancing
enrichment
functional
pathways
associated
antioxidant
defense.
conclusion,
effectively
alleviates
diseases
caused
infection,
promotes
growth
beneficial
bacteria,
improves
capacity
animals.
Additionally,
these
findings
confirm
APR’s
role
addressing
immediate
effects
rather
than
chronic
adaptations.
Future
studies
should
investigate
prolonged
beyond
acute
phase.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 11, 2025
Bone
marrow
is
vital
for
hematopoiesis,
producing
blood
cells
essential
oxygen
transport,
immune
defense,
and
clotting.
However,
disorders
like
leukemia,
lymphoma,
aplastic
anemia,
myelodysplastic
syndromes
can
severely
disrupt
its
function,
leading
to
life-threatening
complications.
Traditional
treatments,
including
chemotherapy
stem
cell
transplants,
have
significantly
improved
patient
outcomes
but
are
often
associated
with
severe
side
effects
limitations,
necessitating
the
exploration
of
safer,
more
targeted
therapeutic
strategies.
Nanotechnology
has
emerged
as
a
promising
approach
addressing
these
challenges,
particularly
in
delivery
nutraceuticals—bioactive
compounds
derived
from
food
sources
potential
benefits.
Despite
their
promise,
nutraceuticals
face
clinical
limitations
due
poor
bioavailability,
instability,
inefficient
target
sites.
Nanoparticles
offer
viable
solution
by
enhancing
stability,
absorption,
transport
bone
while
minimizing
systemic
effects.
This
study
explores
range
disorders,
conventional
treatment
modalities,
nanoparticles
enhance
nutraceutical-based
therapies.
By
improving
efficacy,
could
revolutionize
disease
management,
providing
patients
effective
less
invasive
options.
These
advancements
represent
significant
step
toward
safer
efficient
approaches,
ultimately
prognosis
overall
health.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 7, 2024
Given
that
ketogenic
diets
(KDs)
are
extremely
high
in
dietary
fat,
we
compared
different
fats
KDs
to
determine
which
was
the
best
for
cancer
prevention.
Specifically,
a
Western
and
15%
carbohydrate
diet
seven
KDs,
containing
either
or
enriched
medium
chain
fatty
acids
(MCTs),
milk
fat
(MF),
palm
oil
(PO),
olive
(OO),
corn
(CO)
fish
(FO)
their
ability
reduce
nicotine-derived
nitrosamine
ketone
(NNK)-induced
lung
mice.
While
all
tested
were
more
effective
at
reducing
nodules
than
diet,
FO-KD
most
nodules.
Correlating
with
this,
mice
on
had
low
blood
glucose
highest
β-hydroxybutyrate
level,
lowest
liver
acid
synthase/carnitine
palmitoyl-1a
ratio
dramatic
increase
fecal
Akkermansia.
We
found
no
damage
induced
by
FO-KD,
while
of
total
cholesterol/HDL
unchanged
diets.
conclude
is
superior
other
NNK-induced
cancer,
perhaps
being
skewing
whole-body
metabolism
from
dependence
as
an
energy
source.
Reproduction and Fertility,
Год журнала:
2024,
Номер
5(2)
Опубликована: Март 18, 2024
Although
numerous
studies
have
demonstrated
the
impact
of
microbiome
manipulation
on
human
health,
research
microbiome's
influence
female
health
remains
relatively
limited
despite
substantial
disease
burden.
In
light
this,
we
present
a
selected
review
clinical
trials
and
preclinical
targeting
both
vaginal
gut
microbiomes
for
prevention
or
treatment
various
gynecologic
conditions.
Specifically,
explore
that
leverage
microbiota
transplants,
probiotics,
prebiotics,
diet
modifications,
engineered
microbial
strains.
A
healthy
females
reproductive
age
consists
lactic
acid-producing
bacteria
predominantly
Lactobacillus
genus,
which
serves
as
protective
barrier
against
pathogens
maintains
balanced
ecosystem.
The
microbiota's
production
short-chain
fatty
acids,
metabolism
primary
bile
modulation
sex
steroid
levels
significant
implications
interplay
between
host
microbes
throughout
body,
ultimately
impacting
health.
By
harnessing
interventions
modulate
microbiomes,
it
becomes
possible
to
not
only
maintain
homeostasis
but
also
mitigate
pathological
While
field
is
still
working
toward
making
broad
recommendations,
current
demonstrate
manipulating
holds
great
potential
addressing
diverse
