Emergent Materials, Год журнала: 2024, Номер unknown
Опубликована: Март 15, 2024
Язык: Английский
Gels, Год журнала: 2023, Номер 9(11), С. 845 - 845
Опубликована: Окт. 25, 2023
AI and ML have emerged as transformative tools in various scientific domains, including hydrogel design. This work explores the integration of techniques realm development, highlighting their significance enhancing design, characterisation, optimisation hydrogels for diverse applications. We introduced concept train underscoring its potential to decode intricate relationships between compositions, structures, properties from complex data sets. In this work, we outlined classical physical chemical setting stage AI/ML advancements. These methods provide a foundational understanding subsequent AI-driven innovations. Numerical analytical empowered by were also included. computational enable predictive simulations behaviour under varying conditions, aiding property customisation. emphasised AI’s impact, elucidating role rapid material discovery, precise predictions, optimal like neural networks support vector machines that expedite pattern recognition modelling using vast datasets, advancing formulation discovery are presented. ML’s influence on revolutionised design expediting optimising properties, reducing costs, enabling technologies address pressing healthcare biomedical challenges, offering innovative solutions drug delivery, tissue engineering, wound healing, more. By harmonising insights with techniques, researchers can unlock unprecedented potentials, tailoring
Язык: Английский
Процитировано
22
Nano Trends, Год журнала: 2023, Номер 4, С. 100025 - 100025
Опубликована: Окт. 9, 2023
3D printing and electrospinning are used to fabricate complex structures with improved properties. Combining potentially creates composite even superior properties for biomedical applications. However, there is limited research, use, literature on this synergy. While extensively in the pharmaceutical industries, printed polymer strength can be due high cooling rate during process, resulting a lack of crystallinity. Additives such as crosslinkers reinforcements particles, nanomaterials, fibers often incorporated into melt improve its One promising reinforcement electrospun nanofibers, which have aspect ratios, specific surface area, porosity. result variability fiber size morphology. Further research needed optimize technique reproducibility. This perspective provides an assessment synergistic technology. study explores potential applications while offering opinions most recent combining electrospinning. The fact that effective integration generate powerful platform develop nanomaterials superstructures highlights significance perspective.
Язык: Английский
Процитировано
21
Gels, Год журнала: 2024, Номер 10(2), С. 122 - 122
Опубликована: Фев. 2, 2024
Gels are attracting materials for energy storage technologies. The strategic development of hydrogels with enhanced physicochemical properties, such as superior mechanical strength, flexibility, and charge transport capabilities, introduces novel prospects advancing next-generation batteries, fuel cells, supercapacitors. Through a refined comprehension gelation chemistry, researchers have achieved notable progress in fabricating endowed stimuli-responsive, self-healing, highly stretchable characteristics. This mini-review delineates the integration into supercapacitors, showcasing compelling instances that underscore versatility hydrogels, including tailorable architectures, conductive nanostructures, 3D frameworks, multifunctionalities. ongoing application creative combinatorial approaches functional hydrogel design is poised to yield immense potential within domain storage.
Язык: Английский
Процитировано
5
Materials Today Bio, Год журнала: 2024, Номер 26, С. 101039 - 101039
Опубликована: Март 29, 2024
In order to improve the wound repair environment, this research has successfully developed a new multifunctional hydrogel dressing, which strong adaptability and can accelerate healing. Pioneering development of metal-ion-controlled dressings, integrates dopamine imidazole double crosslinked networks with metal-ion coordination. The resulting dressing exhibits notable antibacterial effect exceptional mechanical properties, withstanding pressures up 12 kPa, tensions 25 maintaining skin adhesion at 6 kPa. Furthermore, self-heal within only 7-8 s post-injection. Impressively, achieves complete biodegradation short timeframe (37 h). Notably, use various metal ions facilitates painless peeling during degradation period, perfectly aligning requirements an ideal dressing. This study made significant progress in fields trauma materials, providing solutions for dealing harsh post-traumatic environments.
Язык: Английский
Процитировано
5
International Journal of Surgery, Год журнала: 2024, Номер 110(10), С. 6748 - 6762
Опубликована: Июнь 21, 2024
The advent of personalized bone prosthesis materials and their integration into orthopedic surgery has made a profound impact, primarily as result the incorporation three-dimensional (3D) printing technology. By leveraging digital models additive manufacturing techniques, 3D enables creation customized, high-precision implants tailored to address complex anatomical variabilities challenging defects. In this review, we highlight significant progress in utilizing printed prostheses across wide range procedures, including pelvis, hip, knee, foot, ankle, spine surgeries, tumor resections. preoperative planning, surgical navigation, postoperative rehabilitation not only enhances treatment outcomes but also reduces risks, accelerates recovery, optimizes cost-effectiveness. Emphasizing potential for care improved patient outcomes, review underscores pivotal role advancing practice towards precision, efficiency, patient-centric solutions. evolving landscape holds promise revolutionizing approaches, enhancing ultimately improving quality patients.
Язык: Английский
Процитировано
5
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Effective treatment of bone diseases is quite tricky due to the unique nature tissue and complexity repair process. In combination with biological materials, cells factors can provide a highly effective safe strategy for regeneration, especially based on these multifunctional hydrogel interface materials. However, itis still challenge formulate materials fascinating properties (e.g., activity, controllable biodegradability, mechanical strength, excellent cell/tissue adhesion, release properties) their clinical applications in complex processes. this review, we will highlight recent advances developing functional hydrogels. We then discuss barriers producing without sacrificing inherent properties, potential cartilage are discussed. Multifunctional serve as fundamental building block engineering.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 207 - 226
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 11, 2025
Abstract Background Adipose-derived mesenchymal stromal cells (AD-MSCs) and fibroblasts are both widely used in regenerative medicine, demonstrating significant potential for personalized cell therapy. A major challenge their use lies high biological similarity, encompassing morphology, differentiation capabilities, flow cytometric markers, making distinction difficult. Methods In our study, we aimed to compare AD-MSCs obtained from two types of adipose tissue, subcutaneous visceral, alongside skin fibroblasts. Notably, all tissue samples were sourced the same donors. We analyzed surface antigens via cytometry conducted single-cell RNA sequencing, followed by verification with quantitative PCR (qPCR). Results Our results revealed phenotypic similarities between isolated dermal fibroblasts, particularly expression markers characteristic AD-MSCs. However, through in-depth analyses, identified distinct differences these types. Specifically, pinpointed 30 genes exhibiting most variations These associated processes such as remodeling, movement, activation response external stimuli. Among them, MMP1 , MMP3 S100A4 CXCL1 PI16 IGFBP5 COMP further validated using qPCR, clearly differentiate Conclusions scRNA-seq analysis elucidates transcriptional landscape unprecedented resolution, highlighting population-specific intrapopulation heterogeneity. findings underscore importance employing high-resolution techniques identification.
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2025, Номер 17(5), С. 589 - 589
Опубликована: Фев. 23, 2025
Hydrogels are extensively utilized in biomedical fields because of their remarkable properties, including biocompatibility, high water content, flexibility, and elasticity. However, despite substantial progress hydrogel research, creating a adhesive that integrates stretchability, fatigue resistance, reversible adhesion continues to pose significant challenges. In this study, we aimed address these challenges by preparing hydrogels using combination acrylic acid, acrylamide, carboxymethylcellulose methacrylate, thiol-functionalized polyhedral oligomeric silsesquioxane, poly(ethylene glycol) dimethacrylate (PEGDM). By systematically varying the molecular weight PEG, were able precisely adjust mechanical properties hydrogels. Our research revealed PEG 2000 (resulting P1 hydrogel) provided notable strength 717.2 kPa on glass surfaces. This performance is particularly impressive given associated with achieving while maintaining other desirable properties. Beyond its strong capabilities, also demonstrated exceptional support, resistance. These characteristics crucial for applications where needs endure repeated stress deformation without losing effectiveness. The successful development underscores potential as multifunctional material broad range applications. ability tailor through adjustments offers promising approach advanced solutions meet demanding requirements modern industrial
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142256 - 142256
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0