Altered Immune Cell Profiles in the Follicular Fluid of Patients with Poor Ovarian Response According to the POSEIDON Criteria DOI Creative Commons
Ling Zhou,

Zhao Shu-hua,

Jiahuan Luo

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 10663 - 10679

Опубликована: Дек. 1, 2024

This study aims to investigate alterations in immune cell counts within preovulatory follicles of patients with poor ovarian response (POR) during assisted reproductive technology (ART), classified according the POSEIDON criteria. single-centre cross-sectional included 543 women undergoing IVF/ICSI treatment, selected based on specific inclusion and exclusion criteria: 292 normal 251 response. Follicular fluid (FF) was collected day oocyte retrieval analysed by flow cytometry determine proportions macrophages (Mφs), M1 M2 Mφs, T cells (CD4 CD8 cells), dendritic (DCs), including type 1 conventional (cDC1) 2 (cDC2), neutrophils. Multivariable logistic regression assessed relationship between POR, Pearson correlation determined associations number retrieved oocytes, receiver operating characteristic (ROC) curves evaluated predictive power for POR. Immune accounted 52.57% (±23.90%) total population follicular microenvironment, which approximately equal that granulosa cells, Mφs being most abundant, followed sequentially DCs, In overall infiltration microenvironment decreased, whereas polarization increased. increased, a decrease CD4/CD8 ratio. Both cDC1 cDC2 were significantly elevated. Moreover, multivariable revealed macrophage count, CD4 count independent predictors Notably, showed largest area under ROC curve, suggesting its strong potential as biomarker predicting The proportion altered These findings suggest dynamics may play crucial role determining prognosis, indicating targeted immunomodulatory strategies could be considered future therapeutic approaches.

Язык: Английский

Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation DOI Creative Commons

C. Lorincz,

Denise Börzsei, Alexandra Hoffmann

и другие.

Biomedicines, Год журнала: 2024, Номер 12(3), С. 560 - 560

Опубликована: Март 1, 2024

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It well known that female competence depends on the dynamic regulation hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute an increased LH-FSH ratio consequent hyperandrogenism. Shifts in bidirectional interplay between neuroendocrine oxidative/inflammatory homeostasis result accumulation reactive oxygen/nitrogen species inflammatory markers as alterations antioxidant defense mechanisms. Evidence shows lifestyle changes, including regular physical exercise, are recognized most effective first-line management reduce severity PCOS symptoms. The aim our narrative review provide insights into mechanisms target factors PCOS-related hormonal oxidative/antioxidant homeostasis, inflammation, discuss effects which takes account various factors, relation PCOS. A better understanding PCOS-associated circuits, exercise-induced action those targets may improve quality life women

Язык: Английский

Процитировано

11
Macrophages: a double-edged sword in female reproduction and disorders DOI Creative Commons

Mira Park,

Yeon Sun Kim,

Haengseok Song

и другие.

Experimental & Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Reproduction consists of sequential inflammation-like events, primarily within the endometrium, from ovulation to embryo implantation, decidualization and delivery. During reproductive cycle, endometrium repeatedly undergoes cyclic periods proliferation, differentiation, tissue breakdown repair without scarring. Owing their phagocytic activity, macrophages, key players in innate immunity, are thought play crucial roles endometrium. Endometrial macrophages actively participate various stages remodeling, particularly during pregnancy establishment. Traditionally considered simple bystanders that clear debris prevent autoimmune responses homeostasis, now recognized as main actors with broad functional plasticity allows them fine tune balance between pro- anti-inflammatory inflammation, remodeling repair. Homeostatic is determined by sum mediators produced two distinctly polarized macrophage subpopulations. The biased polarization tissue-resident may contribute pathogenesis diseases, such inflammation cancer. Thus, understanding how endometrial homeostasis for deciphering underlying mechanisms disorders. Nanomedicines using extracellular vesicles, nanoparticles noncoding RNAs have recently been applied modulate alleviate disease phenotypes. Despite these advances, functions under physiological pathophysiological conditions remain poorly understood, which complicates development targeted therapies. Here we update current homeostatic function putative contribution dysfunction disorders women, along innovative molecular therapeutics resolve this issue.

Язык: Английский

Процитировано

1
The Circadian Rhythm Regulates the Hepato-ovarian Axis Linking Polycystic Ovary Syndrome and Non-alcoholic Fatty Liver Disease DOI

Yibing Lan,

Bihui Jin, Yuhang Fan

и другие.

Biochemical Genetics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

0
Mesencephalic astrocyte-derived neurotrophic factor ameliorates inflammatory response in polycystic ovary syndrome via inhibiting TLR4-NF-κB-NLRP3 pathway DOI

Shujun Yu,

Chao Hou, Xinru Zhang

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 707, С. 149782 - 149782

Опубликована: Март 12, 2024

Язык: Английский

Процитировано

3
Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review DOI Creative Commons

Y. Li,

Chao Liang Li,

Han Yang

и другие.

BMC Complementary Medicine and Therapies, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 26, 2024

Increasing studies focused on the efficacy of acupuncture pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing vitro fertilization-embryo transfer (IVF-ET). However, debatable conclusions have been drawn from different randomized controlled trials (RCTs), which might be related to doses acupuncture. To evaluate whether has a dose-dependent effect PCOS IVF-ET systematically reviewing. Seven electronic databases were searched inception October 10th, 2024. The Cochrane Collaboration's tool ROB 2.0 (ROB 2.0) provided an assessment for risk bias. dose was extracted, then categorized into high, medium, and low according scoring system results, evidence assessed by Slavin's qualitative best-evidence synthesis approach rigours methodological way. Clinical rate (CPR) regarded as primary outcome. A total 953 subjects met eligibility criteria 12 RCTs included, among two dose, four medium six high dose. overall quality included low, 50.00% (6/12) risk, 16.67% (2/12) some concerns, 33.33% (4/12) risk. Comparing consistent high-dose result high-quality provides strong positive correlation between outcomes. trend indicates that higher yield better IVF-ET. Further confirmation through direct comparisons needed. systematic review registered PROSPERO ( https://www.crd.york.ac.uk/prospero/ ), registration number is CRD42023400187.

Язык: Английский

Процитировано

3
Dissecting Causal Relationships Between Immune Cells, Plasma Metabolites, and PCOS: Evidence From Mediating Mendelian Randomization Analysis DOI Creative Commons

Xia-Li Wang,

Yifang He,

Shikun Chen

и другие.

International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 807 - 823

Опубликована: Март 1, 2025

The relationship between Polycystic ovary syndrome (PCOS) and immune dysregulation, along with metabolic disturbances, remains unclear. This study used Mendelian Randomization (MR) to investigate causal relationships cells, PCOS, possible metabolite mediators. We explored the genetic-level cells focusing on metabolites as potential Data from genome-wide association studies (GWAS) included 731 cell types (n=3757), 1400 plasma (n=8299), PCOS cases (n=797) versus controls (n=140,558). Bidirectional MR analysis examined immune-PCOS relationships, while two-step mediation identified inverse variance-weighted (IVW) method was for primary assessment, sensitivity validating results. a total of 33 that were associated increased or decreased risk (P < 0.05), these also alterations in certain levels 0.05). Among them, 12 found influence occurrence through 17 metabolites. Notably, effects Myeloid DC %DC, NKT AC, CD20 CD20- CD38-, CD25 memory B cell, HLA DR CD33dim DR+ CD11b+ mediated by multiple development. Similarly, histidine betaine (hercynine) alpha-ketoglutarate ornithine ratio more than one PCOS. highlights impacting metabolites, advancing understanding mechanisms suggesting therapeutic approaches targeting modulation.

Язык: Английский

Процитировано

0
Fine particulate matter components and reproductive hormones in female adults: A 15-year longitudinal cohort study DOI Creative Commons
Siyi Chen, Cui Guo,

Chunquan Ou

и другие.

International Journal of Hygiene and Environmental Health, Год журнала: 2025, Номер 266, С. 114562 - 114562

Опубликована: Март 18, 2025

Few cohort studies have evaluated the long-term impacts of ambient fine particulate matter (PM2.5) and its components on reproductive hormone levels in female adults. We conducted a 15-year retrospective study Taiwan between 2003 2017. The two-year average concentrations PM2.5 components, including sulfate (SO42-), nitrate (NO3-), ammonium (NH4+), organic (OM), black carbon (BC), were assessed at each participant's addresses. Linear mixed models used to examine associations with hormones, follicle-stimulating (FSH), luteinizing (LH), testosterone (T), estradiol (E2), prolactin (PRL). Stratified analyses identify vulnerable populations. 17,152 adults included. Each interquartile range (IQR: 3.545 μg/m3) increase was associated 0.585 mIU/mL [95% confidence interval (CI): 0.190-0.980] FSH levels. Among five PM2.5, BC had strongest positive association [each IQR (0.272 0.863 (95% CI: 0.476-1.250) levels], followed by OM, SO42-, NH4+. Similar found for LH, 0.483 0.225-0.742) 0.684 0.431-0.938) LH per BC, respectively. pollutants marginally decreased E2 increased PRL Non-linear FSH, E2, observed. These also positively T among young Post-menopausal women more susceptible chronic components. Our highlighted adverse exposure hormonal homeostasis, revealing biological mechanism air pollution-reproductive health females. Implementing stringent control pollution can benefit adults, even moderately polluted regions.

Язык: Английский

Процитировано

0
Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice DOI Creative Commons

Hyejin Shin,

Haeseung Lee, Musun Park

и другие.

npj Aging, Год журнала: 2025, Номер 11(1)

Опубликована: Март 26, 2025

Samul-tang (SM) is a traditional prescription widely used in clinical practice for the management of gynecological diseases, especially menstrual regulation and infertility treatment. We previously reported its efficacy increasing mature oocyte production improving ovarian reserves, potentially regulated by rat sarcoma virus (Ras) signaling ovaries aged mice. Although main ingredients SM are known, bioactive compounds responsible protecting function during aging remain unidentified. This study aimed to identify active that significantly contribute therapeutic potential against age-related decline function. The combination butylphthalide oleanolic acid improved similar SM-administered Subsequently, we identified as an compound mimicked SM's effect on enhancing reserve. introduces novel strategy identifying multi-component herbal medicines evaluating combinations vivo model, offering promising avenues female through targeted gene expression modulation.

Язык: Английский

Процитировано

0
Analysis of macrophage polarization and regulation characteristics in ovarian tissues of polycystic ovary syndrome DOI Creative Commons
Yue Yuan,

Yan Mao,

Yang Liu

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 11, 2024

Polycystic ovary syndrome (PCOS) can lead to infertility and increase the risk of endometrial cancer. Analyzing macrophage polarization characteristics in ovarian tissues PCOS is crucial for clinical treatment.

Язык: Английский

Процитировано

2
Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome DOI Creative Commons

Mojtaba Sarvestani,

Alireza Rajabzadeh,

Tahereh Mazoochi

и другие.

BMC Endocrine Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 19, 2024

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disturbance that affects many women worldwide characterized by chronic anovulation, hyperandrogenism, ovarian dysfunction. Placenta-derived mesenchymal stem cells (PDMSCs) are derived from the placenta have advantages over other sources of MSCs in terms availability, safety, immunomodulation.

Язык: Английский

Процитировано

1