Functional & Integrative Genomics, Год журнала: 2024, Номер 24(5)
Опубликована: Сен. 24, 2024
Язык: Английский
Phytomedicine, Год журнала: 2024, Номер 129, С. 155649 - 155649
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
17
Life, Год журнала: 2024, Номер 14(1), С. 88 - 88
Опубликована: Янв. 5, 2024
Cardiovascular disease is the cause of physical infirmity and thousands deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms energy production metabolic processing. Additionally, inflammation accumulation non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces initiation progression atherosclerotic lesions, which are often basis coronary artery disease. The current review critically analyzes published data related experimental use melatonin forestall pathologies. Collectively, these studies document melatonin’s anti-atherosclerotic actions reducing LDL oxidation triglyceride levels, lowering endothelial malfunction, limiting adhesion molecule formation, preventing macrophage polarization M1 pro-inflammatory phenotype, changing cellular metabolism, scavenging destructive reactive oxygen species, proliferation invasion arterial smooth muscle cells into lesioned area, restricting ingrowth blood vessels from vasa vasorum, solidifying plaque cap reduce chance its rupture. Diabetic hyperglycemia, aggravates also inhibited by supplementation animals. potential value non-toxic as a possible inhibitor pathology humans should be seriously considered performing clinical trials using this multifunctional molecule.
Язык: Английский
Процитировано
10
Aging and Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Various signaling pathways are regulated by reactive oxygen species (ROS), which radical intermediates under normal physiological conditions. However, when the buffering capacity of antioxidant enzymes is exceeded accumulation ROS, oxidative stress, and endothelial cell dysfunction occur, have been recognized as key contributors to development atherosclerosis. In this review, an overview provided on mechanisms underlying ROS generation in cells involved regulatory pathways. Further, we discuss induced its relationship with Current knowledge ROS-induced impairment presented, characterized decreased NO bioavailability, intracellular ox-LDL accumulation. Furthermore, biomarkers such products lipid, protein, nucleotide discussed measurements for levels. Novel interventions targeting stress listed potential pharmacotherapies clinical practice. conclusion, review presents a systematic analysis elucidates how manipulation these can safeguard function.
Язык: Английский
Процитировано
8
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Фев. 29, 2024
Background Assessing the impact of dietary live microbe intake on health outcomes has gained increasing interest. This study aimed to elucidate relationship between and Life's Essential 8 (LE8) scores, a metric for cardiovascular (CVH), in U.S. adult population. Methods We analyzed data from 10,531 participants National Health Nutrition Examination Survey (NHANES) spanning 2005–2018. Participants were stratified into low, medium, high groups based Marco's classification system. employed weighted logistic linear regression analyses, along with subgroup, interaction effect, sensitivity analyses. Additionally, Restricted Cubic Splines (RCS) used explore dose-response food CVH different groups. Results Compared low group, medium had significantly higher LE8, β coefficients 2.75 (95% CI: 3.89–5.65) 3.89 6.05–8.11) respectively. moderate reduced risk risk, defined as an LE8 score below 50, odds ratios (OR) 0.73 0.65 Subgroup analysis proved stability results. In shows negative correlation whereas it exhibits positive correlation. contrast, presents distinct inverted “U” shape. Conclusion highlights potential benefits improving scores adults. These findings advocate inclusion microbes recommendations, suggesting their key role enhancement.
Язык: Английский
Процитировано
4
Pharmacological Research, Год журнала: 2024, Номер 209, С. 107466 - 107466
Опубликована: Окт. 15, 2024
Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the pathological mechanisms of MIRI have received attention. Oxidative stress, multiple programmed cell deaths, inflammation and others are all essential contributing to MIRI. Mitochondria energy supply centers cells. Numerous studies found that abnormal mitochondrial function is an "culprit" MIRI, mitophagy mediated phosphatase tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin signaling pathway integral part maintaining function. Therefore, exploring association between PINK1/Parkin pathway-mediated crucial. This review will mainly summarize crucial role in MIR-induced several various potential interventions affect mitophagy, thus ameliorating
Язык: Английский
Процитировано
4
Pharmacognosy Magazine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Background In Mexico, the fruit of Manilkara zapota (L.) P. Royen (Chicozapote) tree is widely consumed; however, numerous studies have identified bioactive compounds within its leaves. Purpose To evaluate properties M. leaf extracts, focusing on their anti-oxidant, anti-diabetic, and anti-hypertensive potentials, assessing efficacy in mitigating inflammation. Materials Methods This study evaluated anti-oxidant aqueous (AE), ethanolic (EE), hydroalcoholic (HE) utilizing 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Anti-diabetic activity was assessed by inhibiting enzymes α-amylase α-glucosidase, while measured via angiotensin-converting enzyme (ACE) inhibition. The anti-inflammatory potential also examined vivo using a murine model 12- O-tetradecanoylphorbol-13-acetate-induced ear edema. Results DPPH assay revealed that all extracts exhibited equivalent capacities at same concentration, with no significant statistical difference ( p < 0.05). Conversely, ABTS demonstrated AE possessed superior (4.6−28.5%) across varying concentrations. EE most potent inhibition α-amylase, ACE, 81.8%, 58.9%, 87.8%, respectively. assays, 5 mg dosage significantly outperformed other extracts. Conclusion These findings suggest mainly through EE, could offer viable natural alternative for reducing inflammation potentially managing diabetes hypertension.
Язык: Английский
Процитировано
0
Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115372 - 115372
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Pineal Research, Год журнала: 2025, Номер 77(3)
Опубликована: Апрель 1, 2025
The purpose of this investigational study was to assess the cardiovascular effects melatonin replacement therapy in pinealectomized patients. This a prospective open-label, single-arm proof-of-concept comprised 11 patients aged 16.7 ± 1.7 years, who had undergone pinealectomy, experienced no tumor recurrence, and exhibited undetectable salivary levels. A 6-month regimen (0.3 mg daily) administered. Ambulatory blood pressure monitoring conducted at baseline, 3-month, intervals. First all, hypertension observed Over course study, diastolic progressively decreased, reaching statistical significance 6 months. Pulse gradual increase, after Short-term variability increased significantly for both systolic pressures. Morning levels were decreased by therapy. Melatonin effect on average heart rate or its variability. Melatonin-deficient normotensive. these led reduced pressure, pulse enhanced short-term These results are consistent with improved health. Furthermore, melatonin's temporal specificity suggests that it might enhance nighttime recovery, heightening reactivity during wakefulness. While is used as dietary supplement similar effects, caution advised, further research needed optimize use various health disease contexts. Further, considering study's limitations, more extensive would strengthen findings.
Язык: Английский
Процитировано
0
Xenobiotica, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Апрель 16, 2025
Phthalates, widely utilized as plasticisers to enhance the flexibility of rigid materials like polyvinyl chloride, are known for their endocrine-disrupting properties and cytotoxic effects. This study investigated impact Diisononyl phthalate (DINP) Diethyl-hexyl terephthalate (DEHT) on human endothelial cells (EA.hy926). The assessment focused cell viability, reactive oxygen species (ROS) production, antioxidant-responsive genes expression (NFE2L2, SOD1, TXN, TXNRD2) following exposure varying 1, 10, 100 µg/mL DINP or DEHT. Cell viability was determined using MTT lactate dehydrogenase (LDH) release assays. ROS were measured DCFDA assay. Gene analysis conducted via qRT-PCR after 48 h exposure. Results revealed that significantly reduced at 11 17% 72 h, respectively; whereas increased LDH by 69% 48h. levels also rose 19-30%, accompanied down-regulation NFE2L2, TXNRD2. Conversely, DEHT had no adverse effect but elevated production (11-14%) induced up-regulation antioxidant genes, including SOD1. findings indicate could negatively affect cellular response, leads without detrimental effects viability.
Язык: Английский
Процитировано
0
PLoS ONE, Год журнала: 2024, Номер 19(2), С. e0299382 - e0299382
Опубликована: Фев. 23, 2024
Background Endothelial cell injury is one of the important pathogenic mechanisms in thrombotic diseases, and also neutrophils are involved. MicroRNAs (miRNAs) have been demonstrated to act as essential players endothelial injury, but potential molecular processes unknown. In this study, we used cellular tests ascertain protective effect miR-328-3p on human umbilical vein cells (HUVECs) treated with oxygen-glucose deprivation (OGD). Methods our an OGD-induced HUVECs model was established, constructed lentiviral vectors establish stable lines. Toll-like receptor 2 (TLR2) interacted, by dual luciferase reporter assay. We CCK8, LDH release, EdU assays evaluate proliferative capacity each group cells. To investigate expression TLR2, p-P65 NF-κB, P65 NLRP3, IL-1β, IL-18, employed Western blot ELISA. Following OGD, group’s supernatants were gathered co-cultured neutrophils. An immunofluorescence assay Transwell performed determine whether miR-328-3p/TLR2 interferes neutrophil migration extracellular traps (NETs) formation. Results OGD-treated HUVECs, downregulated. directly targets inhibits NF-κB signaling pathway, reverses while inhibiting trap Conclusions pathway NETs formation, ameliorating which provides new ideas for pathogenesis diseases.
Язык: Английский
Процитировано
3