Current Problems in Cardiology, Год журнала: 2024, Номер unknown, С. 102968 - 102968
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Cellular Physiology, Год журнала: 2024, Номер 239(11)
Опубликована: Июль 22, 2024
The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its function can lead to various diseases. ER stress triggers an adaptive response called the unfolded (UPR), which either restore cellular homeostasis or induce cell death. Melatonin, a safe multifunctional compound, shows promise controlling could be valuable therapeutic agent managing UPR. By regulating mitochondrial functions, melatonin helps maintain via reduction of oxidative stress, inflammation, apoptosis. Melatonin directly indirectly interfere with ER-associated sensors downstream targets UPR, impacting death, autophagy, molecular repair, among others. Crucially, this review explores mechanistic role on diseases including liver damage, neurodegeneration, reproductive disorders, pulmonary disease, cardiomyopathy, insulin resistance, renal dysfunction, cancer. Interestingly, while it alleviates burden most pathological contexts, paradoxically stimulate cancer cells, highlighting intricate involvement homeostasis. With numerous successful studies using vivo vitro models, continuation clinical trials imperative fully explore melatonin's potential these conditions.
Язык: Английский
Процитировано
6
Science Progress, Год журнала: 2024, Номер 107(4)
Опубликована: Окт. 1, 2024
Melatonin, N-acetyl-5-methoxytryptamine, is a neuroendocrine hormone secreted by the pineal gland. This pleiotropic indoleamine possesses amphiphilic properties, allowing it to penetrate most biological barriers and exert its effects at subcellular level. Importantly, melatonin also plays crucial role in regulating body's response circadian rhythms, adapting internal external environmental cues. Melatonin functions as powerful antioxidant free radical scavenger, protecting cells from oxidative damage. Its diverse physiological roles include maintaining functional integrity of endothelial cells, thereby preventing atherosclerosis, major contributor cardiovascular disease. Additionally, exhibits scavenging potentially improving metabolic disorders. These combined suggest unique adjunctive therapeutic potential for treating diseases. review aims explore mechanisms which interacts with system investigates use an agent managing
Язык: Английский
Процитировано
4
Life, Год журнала: 2025, Номер 15(2), С. 270 - 270
Опубликована: Фев. 11, 2025
The life functions of eukaryotic cells are intricately regulated by mitochondria [...]
Язык: Английский
Процитировано
0
Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(3)
Опубликована: Фев. 26, 2025
ABSTRACT Melatonin exhibits various biological functions, including regulation of circadian and endocrine rhythms, anti‐inflammatory, antioxidant effects. Aging damaged mitochondria are major sources oxidative stress (OS), mitochondrial quality control (MQC) is crucial for maintaining normal function. Myocardial ischemia‐reperfusion injury a complication that can arise during reperfusion therapy coronary heart disease. However, effective intervention strategies currently lacking. Mitochondrial dysfunction OS considered central mechanisms myocardial injury, with mitochondrial‐targeted interventions being potential treatment direction. Recent studies have shown melatonin improves structure function through multiple pathways. This review discusses the by which ameliorates focusing on MQC, explores its applications in prevention injury.
Язык: Английский
Процитировано
0
Journal of Cardiothoracic Surgery, Год журнала: 2025, Номер 20(1)
Опубликована: Апрель 12, 2025
Delaying the development of atherosclerosis (AS) and decreasing cardiac ischemia-reperfusion damage remain serious challenges for medical community. Chronic arterial disease, i.e., AS, is frequently linked to oxidative stress inflammation as significant contributing causes. AS risk factors, such hyperlipidemia, high blood pressure, age, hyperglycemia, smoking, cholesterol, irregular sleep patterns, can exacerbate in carotid artery further shrink its lumen. Finding new approaches that support plaque inhibition or stability an ongoing problem. The last ten years have shown us melatonin (MLT) affects cardiovascular system, although exact mechanisms action are yet unknown. MLT's direct free radical scavenger activity, indirect antioxidant qualities, anti-inflammatory capabilities all contribute atheroprotective effects on several pathogenic signaling pathways. Herein, we examine evidence showing MLT treatment has protective against AS-related diseases. numerous pieces puzzle been epigenetic biogenetic targets prevention therapy atherosclerotic processes identified.
Язык: Английский
Процитировано
0
Life Sciences, Год журнала: 2024, Номер 355, С. 122993 - 122993
Опубликована: Авг. 16, 2024
Язык: Английский
Процитировано
3
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Дек. 11, 2024
Atherosclerosis is the underlying factor in premature death of millions humans annually. The cause often a result rupture an atherosclerotic plaque followed by discharge associated molecular debris into vessel lumen which occludes artery leading to ischemia downstream tissue and morbidity or mortality individual. This most serious when it occurs heart (heart attack) brain (stroke). Atherosclerotic plaques are classified as either soft, rupture-prone, hard, resistant. Melatonin, production diminishes with age, has major actions converting soft hard plaques. Experimentally, melatonin reduces ingrowth capillaries from tunica media relieving pressure on plaque, reducing intraplaque hemorrhage limiting size necrotic core. Moreover, promotes formation collagen invading vascular smooth muscle cells strengthen crown making resistant rupture. Melatonin also powerful antioxidant anti-inflammatory agent such that oxidative damage tissues limits inflammation both contribute cap weakness. Additional benefits relative atherosclerosis inhibition adhesion molecules endothelial cell surface, invasion monocytes arterial intima, conversion M2 macrophages pro-inflammatory M1 macrophages. Given high physiological financial cost cardiac neural ischemic events, this information should be given priority clinical setting.
Язык: Английский
Процитировано
2
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2024, Номер 20(2), С. 133 - 142
Опубликована: Апрель 19, 2024
In recent years, there has been an interest in studying the specifics of relationships between metabolic syndrome (MetS), sleep disorders and melatonin (MEL). Dyssomnia insomnia are important risk factors for insulin resistance, obesity, MetS, type 2 diabetes mellitus with a degree influence similar to traditional factors. Thus, treatment dyssomnia is one key tasks prevention MetS. The regulation circadian rhythms by exogenous intervention (in particular, use melatonergic drugs) likely play central role MEL acts as powerful antioxidant that can cross blood-brain barrier, suppress oxidative stress, chronic inflammation, interact gut microbiome. From clinical point view, imbalance may indicate “darkness deficit”. It proven neurohormone systemic effects due its mechanisms action, potential course many diseases. Currently, drugs approved exclusively insomnia, jetlag, depression accompanied disorders. However, potentially therapeutic properties neurodegenerative diseases, post-traumatic stress disorder, neuropsychiatric disorders, dementia, autoimmune allergic increasing need products prompted search safe but environmentally friendly medicines. reported phytomelatonin have advantages related improved bioavailability efficacy. purpose this review analyze relationship dyssomnia, MEL. was conducted Scopus, Science Direct (from Elsevier), PubMed, including MEDLINE databases. keywords used were “metabolic syndrome”, “dyssomnia”, “insomnia”, “obstructive apnea”, “melatonin”. We manual bibliography publications identify research results eluded during online search.
Язык: Английский
Процитировано
1
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2024, Номер 20(3), С. 218 - 224
Опубликована: Июнь 27, 2024
Melatonin has several impacts on the cardiovascular system, including potential to reduce blood pressure in addition its role regulating sleep. It ability decrease adrenergic system activity and indirectly enhance endothelial function. can provide antihypertensive effects by stimulating own receptors central nervous peripheral arteries. In addition, melatonin is a treatment for patients with hypertension, “night-peaker” category. However, results of only few randomized trials suggest that supplements are effective hypertension. lower due vasodilatation, direct blocking Ca2+ channels increased production nitric oxide endothelium; antioxidant properties; suppression sympathetic reduction norepinephrine production, as well activation parasympathetic system. Because drug usually taken at bedtime, it may increase duration quality sleep therefore during Low endogenous secretion be associated elevated nocturnal comorbid diseases. exhibits an excellent safety profile. Consequently, larger-scale, longer-term studies higher patient heterogeneity, biomarker identification, idiosyncrasies related use required. The aim this narrative review analyze peculiarities mechanisms action, effect exogenous parameters experiment clinic. search was conducted Scopus, Science Direct (from Elsevier), PubMed, MEDLINE databases. key words used were “melatonin,” “blood pressure”, “hypertension”, “obesity”, “metabolic syndrome”. We manually searched bibliography publications find study online did not yield.
Язык: Английский
Процитировано
1
Current Problems in Cardiology, Год журнала: 2024, Номер unknown, С. 102968 - 102968
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1